Synthesis 2023; 55(14): 2186-2194
A New Method for the Synthesis of 1-Methyl-1H -indole-3-carboxylate Derivatives, Employing Copper(II)
,
Muhammad Saleh Faryabi
We are grateful for the financial support provided by the University of Jiroft for this research, which leads to our exceptional success.
Abstract
We report an efficient method for synthesizing 1-methyl-1H -indole-3-carboxylates by cross-dehydrogenative coupling. However, the coupling reactions are a way to functionalize the α-carbon of iminiums from tertiary amines. The synthesis of 1-methyl-1H -indole-3-carboxylates from N ,N -dimethylaniline with bromoacetates has not been reported. In the present work, we describe a novel route for synthesizing 1-methyl-1H -indole-3-carboxylates with N ,N -dimethylaniline and a wide range of phenyl bromoacetate derivatives. Features such as a simple procedure and good to excellent yields (69–90%) make this method a highly efficient procedure for the preparation of indole derivatives using Cu(OAc)2 ·H2 O as a catalyst in the presence of tert -butyl hydroperoxide.
Key words
1-methyl-1
H -indole-3-carboxylates -
heterocycles -
cross-dehydrogenative coupling -
copper -
heterogeneous catalysis -
oxidation
Supporting Information
Supporting information for this article is available online at https://doi.org/10.1055/a-2035-0040.
Supporting Information
Publication History
Received: 08 December 2022
© 2023. Thieme. All rights reserved
Georg Thieme Verlag KG
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