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Horm Metab Res 2023; 55(05): 355-366
DOI: 10.1055/a-2043-7707
Original Article: Endocrine Care

C Allele of the PPARδ+294T>C Polymorphism Confers a Higher Risk of Hypercholesterolemia, but not Obesity and Insulin Resistance: A Systematic Review and Meta-Analysis

Shujin Li‡
1   Central Laboratory, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, China
,
Youjin Zhang‡
1   Central Laboratory, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, China
,
Wenhao Xu
2   Clinical Medical College of Chengdu University, Chengdu, China
,
Zhimin Lv
2   Clinical Medical College of Chengdu University, Chengdu, China
,
Luying Xu
2   Clinical Medical College of Chengdu University, Chengdu, China
,
Zixuan Zhao
2   Clinical Medical College of Chengdu University, Chengdu, China
,
Dan Zhu
2   Clinical Medical College of Chengdu University, Chengdu, China
,
Yongyan Song
1   Central Laboratory, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, China
› Author Affiliations Funding Information Scientific Research Project of Clinical Medical College & Affiliated Hospital of Chengdu University — Y202244; Chengdu Medical Research Project — 2022554
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Abstract

The relationships of the PPARα Leu162Val and PPARδ+294 T>C polymorphisms with metabolic indexes have been reported to be inconsistent and even contradictory. The meta-analysis was conducted to clarify the relationships between the two variants and the indexes of obesity, insulin resistance, and blood lipids. PubMed, Google Scholar, Embase, and Cochrane Library were searched for eligible studies. Standardized mean difference with 95% confidence interval was calculated to estimate the differences in the metabolic indexes between the genotypes of the Leu162Val and+294 T>C polymorphisms. Heterogeneity among studies was assessed by Cochran’s x2-based Q-statistic test. Publication bias was identified by using Begg’s test. Forty-one studies (44 585 subjects) and 33 studies (23 018 subjects) were identified in the analyses for the Leu162Val and+294 T>C polymorphisms, respectively. C allele carriers of the+294 T>C polymorphism had significantly higher levels of total cholesterol and low-density lipoprotein cholesterol than TT homozygotes in the whole population. Notably, C allele carriers of the+294 T>C polymorphism had significantly higher levels of triglycerides and total cholesterol in East Asians, but lower levels of triglycerides in West Asians than TT homozygotes. Regarding the Leu162Val polymorphism, it was found that Val allele carriers had significantly higher levels of blood glucose than Leu/Leu homozygotes only in European Caucasians. The meta-analysis demonstrates that C allele of the+294 T>C polymorphism in PPARδ gene confers a higher risk of hypercholesterolemia, which may partly explain the relationship between this variant and coronary artery disease.

Key words

PPARα - PPARδ - Leu162Val - 294 T>C - hypercholesterolemia

Supplementary Material



Publication History

Received: 22 October 2022

Accepted after revision: 23 February 2023

Article published online:
03 April 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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