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Int J Sports Med 2023; 44(08): 584-591
DOI: 10.1055/a-2044-8691
Training & Testing

Effects of Exercise Intensity on Cardiometabolic Parameters of Ovariectomized Obese Mice

Adriano Dos-Santos
1   Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil
,
Bruno do Nascimento Carvalho 
2   Heart Institute, department of hypertension, University of Sao Paulo, Faculty of Medicine, Sao Paulo, Brazil
,
Nicolas Da Costa-Santos
1   Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil
,
Fernanda Queiroz de Mello-Silva 
1   Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil
,
Abel de Assis Pereira
1   Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil
,
Ney Roberto de Jesus
1   Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil
,
Kátia De Angelis 
3   Department of Medicine, Federal University of Sao Paulo, Brazil
,
Maria Claudia Irigoyen
2   Heart Institute, department of hypertension, University of Sao Paulo, Faculty of Medicine, Sao Paulo, Brazil
,
Nathalia Bernardes
1   Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil
,
Erico Chagas Caperuto
1   Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil
,
Katia Bilhar Scapini
1   Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil
,
Iris Callado Sanches
1   Human Movement Laboratory, Sao Judas Tadeu University, Sao Paulo, Brazil
› Author Affiliations Funding This study was financed by the Coordination for the Improvement of Higher Education Personnel (CAPES), Brazilian National Council for Scientific and Technological Development (CNPq) and Anima Institute (AI). B.N.C., A.S. and N.C.S. were recipients of CAPES-PROSUP scholarship. I.C.S. was recipient of CNPq/Universal (435123/2018–1).
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Abstract

The aim of this study was to compare the effects of continuous-moderate vs. high-intensity interval aerobic training on cardiovascular and metabolic parameters in ovariectomized high-fat-fed mice. C57BL/6 female ovariectomized were divided into four groups (n=8): low-fat-fed sedentary (SLF); high-fat-fed sedentary (SHF); high-fat-fed moderate-intensity continuous trained (MICT-HF); and high-fat-fed high-intensity interval aerobic trained (HIIT-HF). The high-fat diet lasted 10 weeks. Ovariectomy was performed in the fourth week. The exercise training was carried out in the last four weeks of protocol. Fasting glycemia, oral glucose tolerance, arterial pressure, baroreflex sensitivity, and cardiovascular autonomic modulation were evaluated. Moderate-intensity continuous training prevented the increase in arterial pressure and promoted a reduction in HR at rest, associated with an improvement in the sympathovagal balance in MICT-HF vs. SHF. The high-intensity interval training reduced blood glucose and glucose intolerance in HIIT-HF vs. SHF and MICT-HF. In addition, it improved sympathovagal balance in HIIT-HF vs. SHF. Moderate-intensity continuous training was more effective in promoting cardiovascular benefits, while high-intensity interval training was more effective in promoting metabolic benefits.

Key words

menopause - obesity - exercise training - heart rate variability - high-fat diet - high-intensity interval training


Publication History

Received: 13 September 2022

Accepted: 09 February 2023

Article published online:
05 May 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
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