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DOI: 10.1055/a-2044-9772
Hectogram-Scale Synthesis of Indobufen from Diludine-Triggered Metal-Free Cascade
Abstract
In this study, indobufen was successfully synthesized from diludine-triggered metal-free cascade in good yield. This process includes esterification, reduction, reductive amination/condensation cascade, hydrolysis, and recrystallization. Additionally, the post-treatment procedure was greatly simplified, and indobufen can be obtained by simple recrystallization that complies with the pharmacopoeia standards. Moreover, this work will be used as a basis for further research into the efficient production of indobufen on an industrial scale.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2044-9772.
- Supporting Information
Publication History
Received: 05 January 2023
Accepted after revision: 23 February 2023
Accepted Manuscript online:
01 March 2023
Article published online:
19 April 2023
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