Die Hüftgelenkdysplasie des Hundes – Therapie

Zur Behandlung der Hüftgelenkdysplasie existieren eine Vielzahl verschiedener Therapieoptionen. Neben chirurgischen Maßnahmen unterschiedlichen Umfangs nehmen konservative Behandlungsmethoden einen wichtigen Stellenwert ein. Ziel ist es stets, die Mobilität und Lebensqualität der betroffenen Patienten zu verbessern.

Publikationsverlauf

Artikel online veröffentlicht:
24. Oktober 2023

• Literatur

• 1 Ginja M, Gaspar AR, Ginja C. Emerging insights into the genetic basis of canine hip dysplasia. Vet Med (Auckl) 2015; 6: 193-202
• 2 King MD. Etiopathogenesis of Canine Hip Dysplasia, Prevalence, and Genetics. Vet Clin North Am Small Anim Pract 2017; 47 (04) 753-767
• 3 Dycus DL, Levine D, Marcellin-Little DJ. Physical Rehabilitation for the Management of Canine Hip Dysplasia. Vet Clin North Am Small Anim Pract 2017; 47 (04) 823-850
• 4 Harper TAM. Conservative Management of Hip Dysplasia. Vet Clin North Am Small Anim Pract 2017; 47 (04) 807-821
• 5 Impellizeri JA, Tetrick MA, Muir P. Effect of weight reduction on clinical signs of lameness in dogs with hip osteoarthritis. J Am Vet Med Assoc 2000; 216 (07) 1089-1091
• 6 Kealy RD, Lawler DF, Ballam JM. et al. Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs. J Am Vet Med Assoc 2000; 217 (11) 1678-1680
• 7 Smith GK, Paster ER, Powers MY. et al. Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs. J Am Vet Med Assoc 2006; 229 (05) 690-693
• 8 Hielm-Bjorkman A, Roine J, Elo K. et al. An un-commissioned randomized, placebo-controlled double-blind study to test the effect of deep sea fish oil as a pain reliever for dogs suffering from canine OA. BMC Vet Res 2012; 8: 157
• 9 Rialland P, Bichot S, Lussier B. et al. Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Can J Vet Res 2013; 77 (01) 66-74
• 10 Lust G, Williams AJ, Burton-Wurster N. et al. Effects of intramuscular administration of glycosaminoglycan polysulfates on signs of incipient hip dysplasia in growing pups. Am J Vet Res 1992; 53 (10) 1836-1843
• 11 Todhunter RJ, Lust G. Polysulfated glycosaminoglycan in the treatment of osteoarthritis. J Am Vet Med Assoc 1994; 204 (08) 1245-1251
• 12 Fujiki M, Shineha J, Yamanokuchi K. et al. Effects of treatment with polysulfated glycosaminoglycan on serum cartilage oligomeric matrix protein and C-reactive protein concentrations, serum matrix metalloproteinase-2 and -9 activities, and lameness in dogs with osteoarthritis. Am J Vet Res 2007; 68 (08) 827-833
• 13 Haan JJ de Goring RL, Beale BS. Evaluation of polysulfated glycosaminoglycan for the treatment of hip dysplasia in dogs. Vet Surg 1994; 23 (03) 177-181
• 14 Kirkby KA, Lewis DD. Canine hip dysplasia: reviewing the evidence for nonsurgical management. Vet Surg 2012; 41 (01) 2-9
• 15 Pollmeier M, Toulemonde C, Fleishman C, Hanson PD. Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis. Vet Rec 2006; 159 (17) 547-551
• 16 Moreau M, Dupuis J, Bonneau NH, Desnoyers M. Clinical evaluation of a nutraceutical, carprofen and meloxicam for the treatment of dogs with osteoarthritis. Vet Rec 2003; 152 (11) 323-329
• 17 Mansa S, Palmer E, Grondahl C. et al. Long-term treatment with carprofen of 805 dogs with osteoarthritis. Vet Rec 2007; 160 (13) 427-430
• 18 Reymond N, Speranza C, Gruet P. et al. Robenacoxib vs. carprofen for the treatment of canine osteoarthritis; a randomized, noninferiority clinical trial. J Vet Pharmacol Ther 2012; 35 (02) 175-183
• 19 Monteiro-Steagall BP, Steagall PV, Lascelles BD. Systematic review of nonsteroidal anti-inflammatory drug-induced adverse effects in dogs. J Vet Intern Med 2013; 27 (05) 1011-1019
• 20 Rausch-Derra L, Huebner M, Wofford J, Rhodes L. A Prospective, Randomized, Masked, Placebo-Controlled Multisite Clinical Study of Grapiprant, an EP4 Prostaglandin Receptor Antagonist (PRA), in Dogs with Osteoarthritis. J Vet Intern Med 2016; 30 (03) 756-763
• 21 Sartini I, Giorgi M. Grapiprant: A snapshot of the current knowledge. J Vet Pharmacol Ther 2021; 44 (05) 679-688
• 22 Kong VK, Irwin MG. Gabapentin: a multimodal perioperative drug?. Br J Anaesth 2007; 99 (06) 775-786
• 23 Di Cesare F, Negro V, Ravasio G. et al. Gabapentin: Clinical Use and Pharmacokinetics in Dogs, Cats, and Horses. Animals(Basel) 2023; 13 (12) 2045
• 24 Corral MJ, Moyaert H, Fernandes T. et al. A prospective, randomized, blinded, placebo-controlled multisite clinical study of bedinvetmab, a canine monoclonal antibody targeting nerve growth factor, in dogs with osteoarthritis. Vet Anaesth Analg 2021; 48 (06) 943-955
• 25 Enomoto M, Mantyh PW, Murrell J. et al. Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats. Vet Rec 2019; 184 (01) 23
• 26 Krautmann M, Walters R, Cole P. et al. Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs. Vet J 2021; 276: 105733
• 27 Sharun K, Jambagi K, Dhama K. et al. Therapeutic Potential of Platelet-Rich Plasma in Canine Medicine. Arch Razi Inst 2021; 76 (04) 721-730
• 28 Cuervo B, Rubio M, Chicharro D. et al. Objective Comparison between Platelet Rich Plasma Alone and in Combination with Physical Therapy in Dogs with Osteoarthritis Caused by Hip Dysplasia. Animals (Basel) 2020; 10 (02) 175
• 29 Okamoto-Okubo CE, Cassu RN, Joaquim JGF. et al. Chronic pain and gait analysis in dogs with degenerative hip joint disease treated with repeated intra-articular injections of platelet-rich plasma or allogeneic adipose-derived stem cells. J Vet Med Sci 2021; 83 (05) 881-888
• 30 Black LL, Gaynor J, Gahring D. et al. Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet Ther 2007; 8 (04) 272-284
• 31 Ivanovska A, Wang M, Arshaghi TE. et al. Manufacturing Mesenchymal Stromal Cells for the Treatment of Osteoarthritis in Canine Patients: Challenges and Recommendations. Front Vet Sci 2022; 9: 897150
• 32 Wits MI, Tobin GC, Silveira MD. et al. Combining canine mesenchymal stromal cells and hyaluronic acid for cartilage repair. Genet Mol Biol 2020; 43 (01) e20190275
• 33 Vilar JM, Cuervo B, Rubio M. et al. Effect of intraarticular inoculation of mesenchymal stem cells in dogs with hip osteoarthritis by means of objective force platform gait analysis: concordance with numeric subjective scoring scales. BMC Vet Res 2016; 12 (01) 223
• 34 Sobczak N, Kantyka M. Hirudotherapy in veterinary medicine. Ann Parasitol 2014; 60 (02) 89-92
• 35 Loeser J, Layer B, Plata C. et al. Hirudotherapy attenuates arthritic pain in patients with various chronic pain syndromes: A retrospective analysis. J Integr Med 2020; 18 (05) 425-433
• 36 Deisenroth A, Nolte I, Wefstaedt P. Use of gold implants as a treatment of pain related to canine hip dysplasia – a review. Part 2: Clinical trials and case reports. Tierarztl Prax Ausg K Kleintiere Heimtiere 2013; 41 (04) 244-254
• 37 Hielm-Bjorkman A, Raekallio M, Kuusela E. et al. Double-blind evaluation of implants of gold wire at acupuncture points in the dog as a treatment for osteoarthritis induced by hip dysplasia. Vet Rec 2001; 149 (15) 452-456
• 38 Jaeger GT, Larsen S, Moe L. Stratification, blinding and placebo effect in a randomized, double blind placebo-controlled clinical trial of gold bead implantation in dogs with hip dysplasia. Acta Vet Scand 2005; 46(1 – 2): 57-68
• 39 Lie KI, Jaeger G, Nordstoga K, Moe L. Inflammatory response to therapeutic gold bead implantation in canine hip joint osteoarthritis. Vet Pathol 2011; 48 (06) 1118-1124
• 40 Farrell M, Clements DN, Mellor D. et al. Retrospective evaluation of the long-term outcome of non-surgical management of 74 dogs with clinical hip dysplasia. Vet Rec 2007; 160 (15) 506-511
• 41 Patricelli AJ, Dueland RT, Adams WM. et al. Juvenile pubic symphysiodesis in dysplastic puppies at 15 and 20 weeks of age. Vet Surg 2002; 31 (05) 435-444
• 42 Manley PA, Adams WM, Danielson KC. et al. Long-term outcome of juvenile pubic symphysiodesis and triple pelvic osteotomy in dogs with hip dysplasia. J Am Vet Med Assoc 2007; 230 (02) 206-210
• 43 Dueland RT, Adams WM, Patricelli AJ. et al. Canine hip dysplasia treated by juvenile pubic symphysiodesis. Part I: two year results of computed tomography and distraction index. Vet Comp Orthop Traumatol 2010; 23 (05) 306-317
• 44 Dueland RT, Patricelli AJ, Adams WM. et al. Canine hip dysplasia treated by juvenile pubic symphysiodesis. Part II: two year clinical results. Vet Comp Orthop Traumatol 2010; 23 (05) 318-325
• 45 Zhang Z, Zhu L, Sandler J. et al. Estimation of heritabilities, genetic correlations, and breeding values of four traits that collectively define hip dysplasia in dogs. Am J Vet Res 2009; 70 (04) 483-492
• 46 Slocum B, Slocum TD. Pelvic osteotomy for axial rotation of the acetabular segment in dogs with hip dysplasia. Vet Clin North Am Small Anim Pract 1992; 22 (03) 645-682
• 47 Borostyankoi F, Rooks RL, Kobluk CN. et al. Results of single-session bilateral triple pelvic osteotomy with an eight-hole iliac bone plate in dogs: 95 cases (1996–1999). J Am Vet Med Assoc 2003; 222 (01) 54-59
• 48 Rose SA, Bruecker KA, Petersen SW, Uddin N. Use of locking plate and screws for triple pelvic osteotomy. Vet Surg 2012; 41 (01) 114-120
• 49 Slocum B. Triple pelvic osteotomy. J Am Anim Hosp Assoc 1998; 34 (05) 361-363
• 50 Vezzoni A, Boiocchi S, Vezzoni L. et al. Double pelvic osteotomy for the treatment of hip dysplasia in young dogs. Vet Comp Orthop Traumatol 2010; 23 (06) 444-452
• 51 Giebels F, Prescher A, Wagenpfeil S. et al. Nerve distribution and density in the canine hip joint capsule. Comparison of healthy and dysplastic hip joints. Tierarztl Prax Ausg K Kleintiere Heimtiere 2017; 45 (02) 77-83
• 52 Kinzel S, Hein S, von Scheven C, Kupper W. 10 years experience with denervation of the hip joint capsule for treatment of canine hip joint dysplasia and arthrosis. Berl Munch Tierarztl Wochenschr 2002; 115(1 – 2): 53-56
• 53 Lister SA, Roush JK, Renberg WC. et al. Ground reaction force analysis of unilateral coxofemoral denervation for the treatment of canine hip dysplasia. Vet Comp Orthop Traumatol 2009; 22 (02) 137-141
• 54 Off W, Matis U. Excision arthroplasty of the hip joint in dogs and cats. Clinical, radiographic, and gait analysis findings from the Department of Surgery, Veterinary Faculty of the Ludwig-Maximilians-University of Munich, Germany. Vet Comp Orthop Traumatol 2010; 23 (05) 297-305
• 55 Engstig M, Vesterinen S, Morelius M. et al. Effect of Femoral Head and Neck Osteotomy on Caninesʼ Functional Pelvic Position and Locomotion. Animals (Basel) 2022; 12 (13) 1631
• 56 Harper TAM. Femoral Head and Neck Excision. Vet Clin North Am Small Anim Pract 2017; 47 (04) 885-897
• 57 Lippincott CL. Femoral head and neck excision in the management of canine hip dysplasia. Vet Clin North Am Small Anim Pract 1992; 22 (03) 721-737
• 58 Duff R, Campbell JR. Long term results of excision arthroplasty of the canine hip. Vet Rec 1977; 101 (10) 181-184
• 59 Fitzpatrick N, Pratola L, Yeadon R. et al. Total hip replacement after failed femoral head and neck excision in two dogs and two cats. Vet Surg 2012; 41 (01) 136-142
• 60 Olmstead ML. Total hip replacement. Vet Clin North Am Small Anim Pract 1987; 17 (04) 943-955
• 61 Bergh MS, Gilley RS, Shofer FS, Kapatkin AS. Complications and radiographic findings following cemented total hip replacement: a retrospective evaluation of 97 dogs. Vet Comp Orthop Traumatol 2006; 19 (03) 172-179
• 62 Fossum TW. Chirurgie der Kleintiere. St. Louis (MO): Elsevier; 2021
• 63 Hummel DW, Lanz OI, Werre SR. Complications of cementless total hip replacement. A retrospective study of 163 cases. Vet Comp Orthop Traumatol 2010; 23 (06) 424-432
• 64 Vezzoni L, Vezzoni A, Boudrieau RJ. Long-Term Outcome of Zurich Cementless Total Hip Arthroplasty in 439 Cases. Vet Surg 2015; 44 (08) 921-929
• 65 Tobias KM, Johnston SA. Veterinary Surgery Small Animal. St. Louis (MO): Elsevier; 2012