Synthesis of Calix[4]arene Appended Lactosylated G1 and Galacto­sylated G2 Generation Glycodendrimers using a ‘CuAAC’ Click Approach

Sunil Kumar; Mangal S. Yadav; Sumit K. Singh; Sanchayita Rajkhowa; Vinod K. Tiwari

doi:10.1055/a-2063-4139

SynOpen, Table of Contents

CC BY 4.0 · SynOpen 2023; 07(02): 145-153
DOI: 10.1055/a-2063-4139

paper

Virtual Collection Click Chemistry and Drug Discovery

Synthesis of Calix[4]arene Appended Lactosylated G₁ and Galactosylated G₂ Generation Glycodendrimers using a ‘CuAAC’ Click Approach

Sunil Kumar

^aDepartment of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India

,

Mangal S. Yadav

^aDepartment of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India

,

Sumit K. Singh

^aDepartment of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India

,

Sanchayita Rajkhowa

^bDepartment of Chemistry, The Royal Global University, Guwahati-781035, Assam, INDIA

,

Vinod K. Tiwari ∗

^aDepartment of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India

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Abstract

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This manuscript is dedicated to (Late) Prof. Alan R. Katritzky for his contributions to benzotriazole chemistry.

Abstract

A modular and highly reliable click approach is applied for the expeditious synthesis of lactose- and galactose-coated calixarene-cored G₁ and G₂ generation glycodendrimers, respectively. The developed calixarene glycodendrimers have been characterized by using extensive spectral analysis including NMR (¹H and ¹³C), MS, IR, and SEC data.

Key words

azide - alkyne - click reaction - calix[4]arene - macrocyclic - glycodendrimer - catalysis

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References

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Supplementary Material

Supporting Information

Synthesis of Calix[4]arene Appended Lactosylated G1 and Galacto­sylated G2 Generation Glycodendrimers using a ‘CuAAC’ Click Approach

Synthesis of Calix[4]arene Appended Lactosylated G₁ and Galactosylated G₂ Generation Glycodendrimers using a ‘CuAAC’ Click Approach