Subscribe to RSS

DOI: 10.1055/a-2067-5481
Lipoinjection with Adipose Stem Cells for Nasal Modeling: Rhino Cell, a Highly Versatile Alternative

Abstract
It is undeniable that a significant number of patients who want to improve their facial appearance is increasingly interested in nonsurgical procedures. Without a doubt, the use of autologous fat could not be left out as a magnificent alternative for nasal modeling simply because of four influential factors: ease of collection, compatibility, the temporality of the results, and safety. This work describes an innovative alternative technique for nasal modeling using micrografts enriched with adipose-derived mesenchymal stem cells (ASCs). With this technique, fat was collected and divided into two samples, nanofat and microfat. Nanofat was used to isolate the ASCs; microfat was enriched with ASCs and used for nasal modeling. Lipoinjection was performed in a supraperiosteal plane on the nasal dorsum. Through a retrolabial access, the nasal tip and base of the columella were lipoinjected. We consider that nonsurgical nasal modeling using micrografts enriched with ASCs can be an attractive and innovative alternative. This technique will never be a substitute for surgical rhinoplasty. It can be performed in a minor procedure area with rapid recovery and return to the patient's daily activities the next day. If necessary, the procedure can be repeated.
Authors' Contributions
Conceptualization: Y.C.-G.; data curation: J.A.G.-G., S.E.V.-L.; formal analysis: C.M.G.C.; methodology: Y.C.-G.; project administration: H.C.-M., Y.C.-G.; visualization: V.H.C.-K.; writing, original draft: Y.C.-G., S.E.V.-L., J.A.G.-G.; writing, review, and editing: Y.C.-G., J.A.G.-G.
Ethical Approval
The study was approved by the Institutional Review Board of Universidad Autonoma de Nuevo Leon, Hospital Universitario “Dr. Jose E. Gonzalez” (registration no. CP 14-003) and performed in accordance with the principles of the Declaration of Helsinki. Written informed consents were obtained.
Patient Consent
Informed consent was obtained from the patient regarding the procedure and subsequent publication.
Publication History
Received: 23 June 2022
Accepted: 15 February 2023
Accepted Manuscript online:
01 April 2023
Article published online:
02 August 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Sánchez-Carpintero I, Candelas D, Ruiz-Rodríguez R. [Dermal fillers: types, indications, and complications]. Actas Dermosifiliogr 2010; 101 (05) 381-393
- 2 Attenello NH, Maas CS. Injectable fillers: review of material and properties. Facial Plast Surg 2015; 31 (01) 29-34
- 3 Guerrerosantos J, Guerrerosantos F, Orozco J. Classification and treatment of facial tissue atrophy in Parry-Romberg disease. Aesthetic Plast Surg 2007; 31 (05) 424-434
- 4 Castro-Govea Y, Vela-Martinez A, Treviño-Garcia LA. Lipoinjection and multiple internal cuts for congenital constriction bands: a new treatment approach. Aesthetic Plast Surg 2017; 41 (02) 375-380
- 5 Gornitsky J, Viezel-Mathieu A, Alnaif N, Azzi AJ, Gilardino MS. A systematic review of the effectiveness and complications of fat grafting in the facial region. JPRAS Open 2018; 19: 87-97
- 6 Kornstein AN, Nikfarjam JS. Fat grafting to the forehead/glabella/radix complex and pyriform aperture: aesthetic and anti-aging implications. Plast Reconstr Surg Glob Open 2015; 3 (08) e500
- 7 Lin S, Hsiao YC, Huang JJ. et al. Minimal invasive rhinoplasty: fat injection for nasal dorsum contouring. Ann Plast Surg 2017; 78 (3, suppl 2): S117-S123
- 8 Castro-Govea Y, De La Garza-Pineda O, Lara-Arias J. et al. Cell-assisted lipotransfer for the treatment of Parry-Romberg syndrome. Arch Plast Surg 2012; 39 (06) 659-662
- 9 Tonnard P, Verpaele A, Peeters G, Hamdi M, Cornelissen M, Declercq H. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg 2013; 132 (04) 1017-1026
- 10 Zuk PA, Zhu M, Mizuno H. et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001; 7 (02) 211-228
- 11 Coleman SR. Structural fat grafts: the ideal filler?. Clin Plast Surg 2001; 28 (01) 111-119
- 12 Cárdenas JC, Carvajal J. Refinement of rhinoplasty with lipoinjection. Aesthetic Plast Surg 2007; 31 (05) 501-505
- 13 Baptista C, Nguyen PS, Desouches C, Magalon G, Bardot J, Casanova D. Correction of sequelae of rhinoplasty by lipofilling. J Plast Reconstr Aesthet Surg 2013; 66 (06) 805-811
- 14 Kao WP, Lin YN, Lin TY. et al. Microautologous fat transplantation for primary augmentation rhinoplasty: long-term monitoring of 198 Asian patients. Aesthet Surg J 2016; 36 (06) 648-656
- 15 Keyhan SO, Ramezanzade S, Bohluli B, Fallahi HR, Mirzahoseini S, Nahai F. Autologous fat injection for augmentation rhinoplasty: a systematic review. Aesthet Surg J Open Forum 2021; 3 (02) ojab010
- 16 Kølle SF, Fischer-Nielsen A, Mathiasen AB. et al. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial. Lancet 2013; 382 (9898): 1113-1120
- 17 Kuno S, Yoshimura K. Condensation of tissue and stem cells for fat grafting. Clin Plast Surg 2015; 42 (02) 191-197
- 18 Rihani J. Microfat and nanofat: when and where these treatments work. Facial Plast Surg Clin North Am 2019; 27 (03) 321-330
- 19 Cohen SR, Tiryaki T, Womack HA, Canikyan S, Schlaudraff KU, Scheflan M. Cellular optimization of nanofat: comparison of two nanofat processing devices in terms of cell count and viability. Aesthet Surg J Open Forum 2019; 1 (04) ojz028
- 20 Tonnard P, Verpaele A, Carvas M. Fat grafting for facial rejuvenation with nanofat grafts. Clin Plast Surg 2020; 47 (01) 53-62