Download PDF
Zeitschrift für Orthomolekulare Medizin 2023; 21(02): 4-8
DOI: 10.1055/a-2067-7524
Wissen

Endocrine Disruptors und Diabetes mellitus

Hans-Peter Friedrichsen
,
Uwe Gröber
› Further Information
    Permissions and Reprints

Zusammenfassung

Endocrine Disrupting Chemicals (EDCs) sind hormonaktive Umweltgifte, die über multiple Mechanismen die endokrine Regulation beinträchtigen. Bes. gravierend ist die Exposition in der Fetalphase, in der auch die metabolische Programmierung erfolgt. Zu den diabetogenen Chemikalien gehören zahlreiche Biozide, aber auch Lösemittel und Phthalate wie Bisphenol A, das in großen Mengen in der Kunststoff- und Nahrungsmittelindustrie eingesetzt wird. Eine hohe Belastung weisen nicht gestillte Kinder im Alter von 0–6 Monaten auf. Neben ihrer direkten schädlichen Wirkung tragen EDCs auch dadurch zu Diabetespathogenese bei, dass sie den Stoffwechsel des protektiven Faktors Vitamin D stören.

Schlüsselwörter

Endocrine Disruptors - Diabetes mellitus - Umweltgifte - endokrine Regulation - Fetalphase - China - diabetogene Chemikalien - Bisphenol-A - Vitamin D


Publication History

Article published online:
12 July 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Lind PM, Lind L. Endocrine-disrupting chemicals and risk of diabetes: an evidence based review. Diabetologia 2018; 61: 1495-1502
    CrossrefPubMedGoogle Scholar
  • 2 Endocrine Society. Common EDCs and where they are found. https://www.endocrine.org/topics/edc/what-edcs-are; Stand: 28. März 2023
  • 3 Street ME, Angelini S, Bernasconi S. et al. Current knowledge on Endocrine Disrupting Chemicals (EDCs) from animal biology to humans, from pregnancy to adulthood; Highlights from a National Italian Meeting. Int J Mol Sci 2018; 19: 1647
    CrossrefPubMedGoogle Scholar
  • 4 Friedrichsen HP. Endocrine Disruptors – Hormonaktive Chemikalien. Zs f Orthomol Med 2004; 4: 12-16
    Google Scholar
  • 5 Friedrichsen HP. Diabestes mellitus – eine Umwelterkrankung?. Zs f Orthomol Med 2014; 3: 5-9
    Google Scholar
  • 6 Street ME, Audouze K, Legler J. et al. Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs. Int J Mol Sci 2021; 22: 933
    CrossrefPubMedGoogle Scholar
  • 7 Prasad M, Gatasheh MK, Alshuniaber MA. Impact of Glyphosate on the Development of Insulin Resistance in Experimental Diabetic Rats: Role of NF-κB Signalling Pathways. Antioxidants 2022; 11: 2436
    CrossrefPubMedGoogle Scholar
  • 8 Yan D, Jiao Y, Yan H. et al. Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis. Environmental Health 2022; 21: 53
    CrossrefPubMedGoogle Scholar
  • 9 Predieri B, Bruzzi P, Bigi P. et al. Endocrine Disrupting Chemicals and Typ 1 Diabetes. Int J Mol Sci 2020; 21: 2937
    CrossrefPubMedGoogle Scholar
  • 10 Howard SG. Developmental Exposure to Endocrine Disrupting Chemicals and Type 1 Diabetes mellitus. Front Endocrinol 2018; 9: 513
    CrossrefPubMedGoogle Scholar
  • 11 Sargis RM, Simmons RA. Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors. Diabetologia 2019; 62: 1811-1822
    CrossrefPubMedGoogle Scholar
  • 12 Gröber U, Holick MF. Diabetes prevention: Vitamin D Supplementation May Not Provide Any Protection If There Is No Evidence of Deficiency!. Nutrients 2019; 11: 2651
    CrossrefPubMedGoogle Scholar