Subscribe to RSS
DOI: 10.1055/a-2073-3660
Nuklearmedizinische Ultraschall-Fusionsbildgebung – Klinische Möglichkeiten und derzeitige Limitationen
Ultrasound Fusion Imaging in Nuclear Medicine – Clinical Impact and Current LimitationsZusammenfassung
Die nuklearmedizinische Ultraschall-Fusionsbildgebung lässt sich unter anderem für die Diagnostik der Schilddrüse und Nebenschilddrüsen klinisch sinnvoll einsetzen und erlaubt die zweifelsfreie räumliche Korrelation metabolischer und morphologischer Informationen. Allerdings beschränkt sich die praktische Anwendung aufgrund derzeit noch limitierender Aspekte auf ausgewählte Fälle und wissenschaftliche Untersuchungen. Die Entwicklung eines integrierten hybriden Detektors zur simultanen nuklearmedizinisch-sonografischen Bildgebung wäre eine Möglichkeit, die bestehenden Limitationen zu überwinden.
Abstract
Ultrasound fusion imaging of nuclear medicine modalities can be used sufficiently for the diagnosis of thyroid and parathyroid diseases as well as for other indications. Therefore, it can contribute to an unambiguous spatial correlation between metabolic and morphologic information. However, its practical application is limited to selected cases and scientific purposes. The development of an integrated hybrid detector for simultaneous fusion imaging maybe helpful to overcome current limitations.
Schlüsselwörter
Ultraschall - Sonographie - Hybridbildgebung - Fusionsultraschall - Schilddrüsenbildgebung - NebenschilddrüsenbildgebungKeywords
Ultrasound - Sonography - Hybrid Imaging - Fusion Ultrasound - Thyroid Imaging - Parathyroid ImagingPublication History
Article published online:
26 May 2023
© 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Auer T, Heidegger I, De Zordo T. et al. Fusion Imaging of Contrast-enhanced Ultrasound With CT or MRI for Kidney Lesions. In Vivo 2019; 33: 203-208 DOI: 10.21873/invivo.11460. (PMID: 30587624)
- 2 Tewes S, Peters I, Tiemeyer A. et al. Evaluation of MRI/Ultrasound Fusion-Guided Prostate Biopsy Using Transrectal and Transperineal Approaches. Biomed Res Int 2017; 2017: 2176471 DOI: 10.1155/2017/2176471. (PMID: 29094042)
- 3 Theodore C, Levaillant JM, Capmas P. et al. MRI and Ultrasound Fusion Imaging for Cervical Cancer. Anticancer Res 2017; 37: 5079-5085 DOI: 10.21873/anticanres.11925. (PMID: 28870937)
- 4 Freesmeyer M, Elsner P, Goetze S. et al. Positron emission tomography/ultrasound fusion technique in patients with malignant melanoma. J Med Imaging Radiat Oncol 2015; 59: 320-325 DOI: 10.1111/1754-9485.12280.
- 5 Freesmeyer M, Drescher R, Winkens T. Unexpected diagnosis of peripheral schwannoma on 18F-fluoroethylcholine PET/CT for localization of prostate cancer recurrence and biopsy under real-time PET/ultrasound fusion guidance. Clin Nucl Med 2014; 39: 385-386 DOI: 10.1097/RLU.0000000000000375 . (PMID: 24561678)
- 6 Drescher R, Muller A, Lesser T. et al. PET/ultrasound fusion for differentiation of Vox implant silicone particles from recurrent cancer. Nuklearmedizin 2013; 52: N29-30
- 7 Garganese G, Bove S, Zagaria L. et al. Fusion of ultrasound and 3D single-photon-emission computed tomography/computed tomography to identify sentinel lymph nodes in vulvar cancer: feasibility study. Ultrasound Obstet Gynecol 2019; 54: 545-551 DOI: 10.1002/uog.20364. (PMID: 31152573)
- 8 Freesmeyer M, Winkens T, Opfermann T. et al. Real-time ultrasound and freehand-SPECT. Experiences with sentinel lymph node mapping. Nuklearmedizin 2014; 53: 259-264 DOI: 10.3413/Nukmed-0680-14-06.
- 9 de Bree R, Pouw B, Heuveling DA. et al. Fusion of Freehand SPECT and Ultrasound to Perform Ultrasound-Guided Fine-Needle Aspiration Cytology of Sentinel Nodes in Head and Neck Cancer. AJNR Am J Neuroradiol 2015; 36: 2153-2158 DOI: 10.3174/ajnr.A4426. (PMID: 26294647)
- 10 Bluemel C, Safak G, Cramer A. et al. Fusion of freehand SPECT and ultrasound: First experience in preoperative localization of sentinel lymph nodes. Eur J Nucl Med Mol Imaging 2016; 43: 2304-2312 DOI: 10.1007/s00259-016-3443-0. (PMID: 27311920)
- 11 Garganese G, Bove S, Fragomeni S. et al. Real-time ultrasound virtual navigation in 3D PET/CT volumes for superficial lymph-node evaluation: innovative fusion examination. Ultrasound Obstet Gynecol 2021; 58: 766-772 DOI: 10.1002/uog.23613. (PMID: 33587289)
- 12 Freesmeyer M, Weigel F, John U. et al. Real-Time DMSA-SPECT/US Fusion Imaging Revealing Nonscarring Loss of Function After Pyelonephritis. Clin Nucl Med 2020; 45: e274-e275 DOI: 10.1097/RLU.0000000000003023. (PMID: 32332307)
- 13 Gühne F, Weigel F, Kühnel C. et al. DMSA-camSPECT/US fusion imaging of children's kidneys – Proof of feasibility. Nuklearmedizin 2020; 59: 26-32 DOI: 10.1055/a-1073-6875.
- 14 de Koekkoek-Doll PK, Maas M, Vogel W. et al. Real-Time Ultrasound Image Fusion with FDG-PET/CT to Perform Fused Image-Guided Fine-Needle Aspiration in Neck Nodes: Feasibility and Diagnostic Value. AJNR Am J Neuroradiol 2021; 42: 566-572 DOI: 10.3174/ajnr.A6938.
- 15 Liu Y, Yu H, Liu J. et al. A Pilot Study of (18)F-DCFPyL PET/CT or PET/MRI and Ultrasound Fusion Targeted Prostate Biopsy for Intra-Prostatic PET-Positive Lesions. Front Oncol 2021; 11: 612157 DOI: 10.3389/fonc.2021.612157. (PMID: 33747927)
- 16 Okur A, Hennersperger C, Runyan B. et al. FhSPECT-US guided needle biopsy of sentinel lymph nodes in the axilla: is it feasible?. Med Image Comput Comput Assist Interv 2014; 17: 577-584 DOI: 10.1007/978-3-319-10404-1_72. (PMID: 25333165)
- 17 Beutler BD, Whang G, Tchelepi H. PET/CT Ultrasound Fusion for Percutaneous Biopsy: A Retrospective Single-Center Study and Review of the Literature. Clin Nucl Med 2022; 47: 692-698 DOI: 10.1097/RLU.0000000000004220. (PMID: 35452012)
- 18 Freesmeyer M, Gühne F. Clarification of a suspicious thyroid nodule by use of camSPECT/US fusion imaging. Endocrine 2017; 58: 199-200 DOI: 10.1007/s12020-017-1397-z. (PMID: 28864861)
- 19 Gühne F, Mothes H, Freesmeyer M. Allocation of parathyroid adenoma and suspicious thyroid nodule by real-time (99m)Tc-MIBI SPECT/US fusion imaging. Endocrine 2016; 54: 560-561 DOI: 10.1007/s12020-016-0994-6. (PMID: 27259507)
- 20 Leder T, Seifert P, Drescher R. et al. Excellent Response to Multimodal Therapy Approach in Hyperfunctioning Metastatic Follicular Thyroid Carcinoma Diagnosed on 123 I-SPECT/Ultrasound Fusion Imaging. Clin Nucl Med 2023; 48: 266-268 DOI: 10.1097/RLU.0000000000004448. (PMID: 36241043)
- 21 Seifert P, Greiser J, Winkens T. et al. Ectopic Retrolaryngeal Parathyroid Adenoma Detected by 18F-Ethylcholine PET/US Fusion Imaging. Clin Nucl Med 2022; 47: 182-184 DOI: 10.1097/RLU.0000000000003865. (PMID: 34406183)
- 22 Seifert P, Gühne F, Freesmeyer M. Hyperfunctioning Papillary Microcarcinoma Diagnosed by 124I PET/Ultrasound Fusion Imaging. Clin Nucl Med 2019; 44: 404-405 DOI: 10.1097/RLU.0000000000002503. (PMID: 30762830)
- 23 Seifert P, Winkens T, Kühnel C. et al. I-124-PET/US Fusion Imaging in Comparison to Conventional Diagnostics and Tc-99m Pertechnetate SPECT/US Fusion Imaging for the Function Assessment of Thyroid Nodules. Ultrasound Med Biol 2019; 45: 2298-2308 DOI: 10.1016/j.ultrasmedbio.2019.05.008. (PMID: 31196748)
- 24 Freesmeyer M, Winkens T, Darr A. Diagnosis of small papillary thyroid cancer via sensor-navigated (124)iodine PET/ultrasound ((124)I-PET/US) fusion. J Clin Endocrinol Metab 2015; 100: 13-14 DOI: 10.1210/jc.2014-3003. (PMID: 25313915)
- 25 Freesmeyer M, Gühne F, Drescher R. et al. Multimodal Characterization of a PSMA-Positive Thyroid Nodule Using (68)Ga-PSMA and (124)Iodine PET/US Fusion Imaging. Diagnostics (Basel) 2022; 12: 472 DOI: 10.3390/diagnostics12020472. (PMID: 35204563)
- 26 Freesmeyer M, Opfermann T. Diagnosis of de quervain's subacute thyroiditis via sensor-navigated 124Iodine PET/ultrasound (124I-PET/US) fusion. Endocrine 2015; 49: 293-295 DOI: 10.1007/s12020-014-0366-z. (PMID: 25060209)
- 27 Gühne F, Winkens T, Mothes H. et al. Differential diagnosis of thyroid nodules via real-time PET/ultrasound (US) fusion in a case of co-existing medullary thyroid cancer and adenoma. J Clin Endocrinol Metab 2013; 98: 4250-4251 DOI: 10.1210/jc.2013-2566. (PMID: 24001745)
- 28 Freesmeyer M, Muller UA, Männel M. et al. Synchronous Metastatic Medullary Thyroid Carcinoma and Paraesophageal Parathyroid Adenoma Detected on 18 F-Ethylcholine PET/US Fusion Imaging. Clin Nucl Med 2022; 47: 977-979 DOI: 10.1097/RLU.0000000000004330. (PMID: 35835113)
- 29 Schenke S, Seifert P, Zimny M. et al. Risk Stratification of Thyroid Nodules Using the Thyroid Imaging Reporting and Data System (TIRADS): The Omission of Thyroid Scintigraphy Increases the Rate of Falsely Suspected Lesions. J Nucl Med 2019; 60: 342-347 DOI: 10.2967/jnumed.118.211912. (PMID: 30097501)
- 30 Freesmeyer M, Winkens T, Weissenrieder L. et al. Fusion iENA Scholar Study: Sensor-Navigated I-124-PET/US Fusion Imaging versus Conventional Diagnostics for Retrospective Functional Assessment of Thyroid Nodules by Medical Students. Sensors (Basel) 2020; 20: 3409 DOI: 10.3390/s20123409. (PMID: 32560336)
- 31 Winkens T, Seifert P, Hollenbach C. et al. The FUSION iENA Study: Comparison of I-124-PET/US Fusion Imaging with Conventional Diagnostics for the Functional Assessment of Thyroid Nodules by Multiple Observers. Nuklearmedizin 2019; 58: 434-442 DOI: 10.1055/a-1031-9832.
- 32 Bluemel C, Kirchner P, Kajdi GW. et al. Localization of Parathyroid Adenoma With Real-Time Ultrasound: Freehand SPECT Fusion. Clin Nucl Med 2016; 41: e141-142 DOI: 10.1097/RLU.0000000000000960.
- 33 Freesmeyer M, Opfermann T, Winkens T. Hybrid integration of real-time US and freehand SPECT: proof of concept in patients with thyroid diseases. Radiology 2014; 271: 856-861 DOI: 10.1148/radiol.14132415 . (PMID: 24475866)