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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(06): 686-693
DOI: 10.1055/a-2073-9534
DOI: 10.1055/a-2073-9534
GebFra Science
Review
Brustimplantatassoziierte Tumoren
Artikel in mehreren Sprachen: English | deutsch
Zusammenfassung
Zusätzlich zu dem anaplastischen großzelligen T-Zell-Lymphom (BIA-ALCL) werden seit einigen Jahren weitere Tumoren im Zusammenhang mit Implantaten beschrieben. Sehr selten traten Plattenepithelkarzinome (SSC) und B-Zell-Lymphome auf. Die ungeklärte Pathogenese sowie das unklare individuelle Risikoprofil bringen eine anhaltende Verunsicherung von Patienten und Ärzten mit sich. Während das BIA-ALCL gehäuft im Zusammenhang mit texturierten Brustimplantaten auftritt, wurden die anderen Tumoren auch bei glattwandiger Textur und anderen Implantatlokalisationen beobachtet. Multiple potenzielle Mechanismen werden diskutiert. Eine vermutlich multifaktorielle Genese, die zu einer chronischen Entzündungsreaktion mit konsekutiver Immunstimulation führt, scheint eine Schlüsselrolle bei der malignen Transformation zu spielen. Für eine spezifische Risikobewertung liegen bisher keine ausreichend validen Daten vor, weshalb diese zurückhaltend erfolgen muss. Dargestellt werden Inzidenz, Pathogenese und Evidenzlevel des aktuellen Wissensstands sowie eine Bewertung und Diskussion der aktuellen Literatur.
Schlüsselwörter
Brustimplantat - Lymphom - BIA-SCC - Immunstimulation - texturierte Implantate - Plattenepithelkarzinom - implantatassoziierte Tumoren - BIA-ALCLPublikationsverlauf
Eingereicht: 06. Februar 2023
Angenommen nach Revision: 13. April 2023
Artikel online veröffentlicht:
06. Juni 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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