Breast Implant-Associated Tumors

Uwe von Fritschen; Thomas Kremer; Lukas Prantl; Alba Fricke

doi:10.1055/a-2073-9534

Geburtshilfe und Frauenheilkunde, Table of Contents

CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(06): 686-693
DOI: 10.1055/a-2073-9534

GebFra Science

Review

Breast Implant-Associated Tumors

Article in several languages: English | deutsch

Authors

Uwe von Fritschen

¹Department of Plastic- and Aesthetic Surgery, Helios Klinik Emil von Behring, Berlin, Germany
Thomas Kremer

²Klinik für Plastische und Handchirurgie mit Schwerbrandverletztenzentrum, Klinikum St. Georg, Dresden, Germany
Lukas Prantl

³Abteilung für Plastische-, Hand- und Rekonstruktive Chirurgie, Universität Regensburg, Regensburg, Germany (Ringgold ID: RIN9147)
Alba Fricke

¹Department of Plastic- and Aesthetic Surgery, Helios Klinik Emil von Behring, Berlin, Germany

⁴Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Medical Faculty of the University of Freiburg, Freiburg, Germany

Abstract

In addition to anaplastic large T-cell lymphomas (BIA-ALCL), other implant-related tumors have been described for some years. Squamous cell carcinoma (SSC) and B-cell lymphomas occurred in very rare cases. The unexplained pathogenesis as well as the unclear individual risk profile is an ongoing source of uncertainty for patients and physicians. The pathogenesis of the tumors is still largely not understood. While BIA-ALCL occurs more frequently with textured breast implants, other tumors were also observed with smooth implants and at other implant sites. Multiple potential mechanisms are discussed. It is suspected that the etiology of a chronic inflammatory response and subsequently immunostimulation is multifactorial and appears to play a key role in the malignant transformation. Since there are currently no sufficiently valid data for a specific risk assessment, this must be done with caution. This article presents the incidence, pathogenesis, as well as the level of evidence according to the current state of knowledge, and evaluates and discusses the current literature.

Keywords

breast implant - lymphoma - BIA-SCC - immunostimulation - textured implants - squamous cell carcinoma - implant-associated tumors - BIA-ALCL

Full Text

References

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