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CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2023; 83(06): 653-663
DOI: 10.1055/a-2074-0551
DOI: 10.1055/a-2074-0551
GebFra Science
Review
Update Mammakarzinom 2023 Teil 1 – Brustkrebs in frühen Krankheitsstadien
Article in several languages: English | deutsch
Zusammenfassung
Mit den Zulassungen von Abemaciclib (monarchE-Studie) und Olaparib (OlympiA-Studie) in der adjuvanten Therapiesituation haben sich die Therapiestandards bei der Behandlung von Patientinnen mit Mammakarzinom in Frühstadien seit Langem deutlich verändert. Somit übertragen sich einige vielfältige Entwicklungen aus der metastasierten Therapiesituation langsam in die adjuvante. Kürzlich ist auch die NATALEE-Studie als positiv berichtet worden.
Weitere Therapiestudien mit Substanzen, die in der metastasierten Situation etabliert sind, werden zurzeit durchgeführt. Dies sind z. B. die DESTINY Breast05-Studie mit Trastuzumab-Deruxtecan und die SASCIA-Studie mit Sacituzumab Govitecan.
In dieser Übersichtsarbeit werden die neuesten Entwicklungen der letzten Monate zusammengefasst und in den jeweiligen Kontext eingeordnet.
Schlüsselwörter
Brustkrebs - Frühstadium - adjuvante Therapie - neoadjuvante Therapie - endokrine Therapie - BiomarkerPublication History
Received: 12 April 2023
Accepted: 13 April 2023
Article published online:
06 June 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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