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DOI: 10.1055/a-2079-9133
Effekte einer Therapie mit Liraglutid bei Jugendlichen mit extremer Adipositas unter Real-Life-Bedingungen
Effects of Liraglutide Treatment in Youth with Extreme Obesity in a Real-Life Setting![](https://www.thieme-connect.de/media/10.1055-s-00034923/202303/lookinside/thumbnails/20799133_10-1055-a-2079-9133-1.jpg)
Zusammenfassung
Bisher zur Verfügung stehende Maßnahmen zur Reduktion und Stabilisierung des Körpergewichts bei Kindern und Jugendlichen mit Adipositas und extremer Adipositas beschränkten sich auf Interventionen durch eine Lebensstilmodifikation, die jedoch häufig nicht in einer langfristigen und klinisch relevanten Gewichtsreduktion resultieren. Metabolisch-chirurgische Operationen werden zunehmend auch im jugendlichen Alter durchgeführt mit der größten Effektivität hinsichtlich einer Reduktion des Körpergewichts, stellen jedoch aufgrund der perioperativen Risiken und der langfristigen Konsequenzen nur im Einzelfall die Therapie der Wahl dar.
Mit dem GLP-1-Agonisten Liraglutid steht nun erstmals in Europa eine medikamentöse Therapie zur Gewichtsreduktion bei Jugendlichen mit Adipositas ab 12 Jahren zur Verfügung. In einer klinischen Studie konnte gezeigt werden, dass die Gabe von Liraglutid 3,0 mg über 52 Wochen, in Kombination mit einer begleitenden Lebensstil-modifizierenden Intervention, bei Jugendlichen zu einer durchschnittlichen BMI-Reduktion von 4,6% führte [1]. Jedoch gibt es bislang kaum Erfahrungsberichte über den Effekt der Liraglutid-Therapie bei Kindern und Jugendlichen>12 Jahren in der Praxis, unter Real-Life Bedingungen. Wir berichten nachfolgend über Erfahrungen aus der Praxis hinsichtlich der Anwendung von Liraglutid (maximale Dosis 3,0 mg) bis zu 9 Monaten bei n=8 Jugendlichen mit extremer Adipositas, die in der Universitätsklinik für Kinder- und Jugendmedizin Ulm behandelt werden, bezogen auf das Körpergewicht, den BMI sowie die Angabe über berichtete Nebenwirkungen.
Abstract
Treatment options to reduce body weight in children and adolescents with obesity and extreme obesity are limited to lifestyle modifications, which, however, often do not result in long-term and clinically relevant body weight reduction. Metabolic surgery is increasingly being performed in adolescence with extreme obesity with the greatest effectiveness in reducing body weight. Due to the perioperative risks and long-term consequences, this treatment is only an option in selected individual cases. With the GLP-1 agonist liraglutide, a drug therapy for weight reduction in adolescents from 12 years of age is now available for the first time in Europe. In a clinical trial, it was shown that the administration of liraglutide 3.0 mg over 52 weeks, in combination with an accompanying lifestyle modification, led to an average BMI reduction of 4.6% in adolescents [1]. There are only few reports on the effect of liraglutide therapy in children and adolescents>12 years of age under real-life conditions. In the following, we report on experience with the use of liraglutide (maximum dose 3.0 mg) in n=8 adolescents with extreme obesity treated at the center for children and adolescents with obesity (Clinic for Pediatrics and Adolescent Medicine, Ulm University Medical Center), in terms of effect of liraglutide therapy on body weight, BMI, BMI-SDS velocity, on hunger and reported side effects.
Publication History
Article published online:
04 September 2023
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