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CC BY 4.0 · J Neurol Surg B Skull Base 2024; 85(04): 347-357
DOI: 10.1055/a-2082-4951
Original Article

Clinical Outcome in Patients with Large Sinonasal Tumors with Intracranial Extension

Max E. Keizer
1   Department of Neurosurgery, Maastricht University Medical Centre + , Maastricht, The Netherlands
2   Dutch Academic Alliance Skull Base Pathology, Maastricht/Nijmegen, The Netherlands
,
Koos E. Hovinga
1   Department of Neurosurgery, Maastricht University Medical Centre + , Maastricht, The Netherlands
2   Dutch Academic Alliance Skull Base Pathology, Maastricht/Nijmegen, The Netherlands
,
Martin Lacko
2   Dutch Academic Alliance Skull Base Pathology, Maastricht/Nijmegen, The Netherlands
3   Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Centre + , Maastricht, The Netherlands
4   School for Oncology and Reproduction (GROW), Maastricht University Medical Centre + , Maastricht, The Netherlands
,
Danielle B.P. Eekers
2   Dutch Academic Alliance Skull Base Pathology, Maastricht/Nijmegen, The Netherlands
4   School for Oncology and Reproduction (GROW), Maastricht University Medical Centre + , Maastricht, The Netherlands
5   Department of Radiation Oncology (Maastro), Maastricht, The Netherlands
,
Laura W.J. Baijens
2   Dutch Academic Alliance Skull Base Pathology, Maastricht/Nijmegen, The Netherlands
3   Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Centre + , Maastricht, The Netherlands
4   School for Oncology and Reproduction (GROW), Maastricht University Medical Centre + , Maastricht, The Netherlands
,
Bernd Kremer
2   Dutch Academic Alliance Skull Base Pathology, Maastricht/Nijmegen, The Netherlands
3   Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Centre + , Maastricht, The Netherlands
4   School for Oncology and Reproduction (GROW), Maastricht University Medical Centre + , Maastricht, The Netherlands
,
Yasin Temel
1   Department of Neurosurgery, Maastricht University Medical Centre + , Maastricht, The Netherlands
2   Dutch Academic Alliance Skull Base Pathology, Maastricht/Nijmegen, The Netherlands
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Abstract

Objectives Malignant tumors of the sinonasal cavities with extension to the frontal skull base are rare and challenging pathologies. Combined-approach surgery using a frontobasal craniotomy and endoscopic sinus surgery with reconstruction of the anterior skull base followed by adjuvant radiotherapy is a preferred treatment strategy in selected cases. Morbidity and mortality rates are high in this population. We aim to add our experience to the current literature.

Design We performed a retrospective cross-sectional single center study of the long-term clinical outcome in a tertiary university referral hospital in the Netherlands between 2010 and 2021. Descriptive statistics and frequency distributions were performed

Participants Patient, tumor, treatment, complications and survival characteristics of eighteen consecutive patients were extracted from the electronic health records.

Main Outcome Measures The primary outcome measures are progression free survival, overall survival and complication rate.

Results Eighteen consecutive patients were included with a mean age of 61 (SD ± 10) years (range 38-80); ten males and eight females. Gross total resection was achieved in 14 (77%) patients. Eleven (61%) patients underwent local radiotherapy, one (5%) chemotherapy and three (17%) a combination of both. Mean follow-up duration was 49 months (range 3 – 138). Three (17%) patients died in hospital due to post-operative complications. Six (33%) patients died during follow-up due to disease progression. Mean progression-free survival was 47 months (range 0 – 113).

Conclusion In conclusion, the overall survival was 50% for this group of patients with large sinonasal tumors. Progressive disease affects survival rate severely. Surgical complications were seen in five (28%) patients. Radiotherapy is associated with high complication rates. Radiation necrosis was a serious complication in two patients and could be treated with high dose steroids.

Keywords

Skull base - esthesioneuroblastoma - sinonasal carcinoma - inverted papilloma - squamous cell carcinoma - adenoid cystic carcinoma - radiotherapy - reconstruction - craniotomy


Publication History

Received: 02 December 2022

Accepted: 24 April 2023

Accepted Manuscript online:
27 April 2023

Article published online:
24 May 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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