Malignes Melanom und Adipositas: eine Übersichtsarbeit

Zusammenfassung

Einleitung Die Inzidenz von Adipositas nimmt weltweit stetig zu. Übergewicht und Adipositas werden als mögliche Risikofaktoren für verschiedene Krebserkrankungen, einschließlich des malignen Melanoms, diskutiert. Dieser Review stellt die Evidenz zu der Assoziation zwischen Adipositas und dem malignen Melanom dar.

Methodik Selektive Literaturrecherche.

Ergebnisse Obwohl verschiedene Erklärungsansätze für eine mögliche Assoziation von Adipositas und dem malignen Melanom existieren, sind diese nicht vollständig bekannt und weiterhin Gegenstand der Forschung. Die Evidenz zur Assoziation zwischen Adipositas und Melanom-Outcomes für Patienten ohne Systemtherapie ist gering. Für Patienten mit Systemtherapie gibt es Evidenz, die einen protektiven Effekt unter Immuntherapien und zielgerichteten Therapien beschreibt.

Schlussfolgerung Insgesamt gibt es zu der Assoziation zwischen dem malignen Melanom und Adipositas nicht ausreichend Evidenz, um zu schlussfolgern, ob Adipositas einen unabhängigen protektiven Effekt hat oder ein Risikofaktor für die Entstehung von Melanomen darstellt. Weitere Forschung ist erforderlich, um das Wissen über diesen möglichen Zusammenhang zu vertiefen.

Abstract

Introduction The incidence of obesity continues to increase worldwide. Obesity is discussed as a potential risk factor for various types of cancer including malignant melanoma. This review presents the evidence for the association between obesity and malignant melanoma.

Methods Selective literature search.

Results Although several explanatory approaches for the association between obesity and malignant melanoma exist, these are currently not fully understood and remain subject of research. The evidence on the association between obesity and melanoma outcomes for patients without systemic therapy is low. For patients with systemic therapy existing evidence points to a protective effect of immuno- and targeted therapies.

Conclusion Overall, current evidence is insufficient to conclude whether obesity has an independent protective effect or is a risk factor for the development of malignant melanoma. Further research is needed to assess this potential association in greater depth.

Schlüsselwörter

Melanom - Adipositas - Body-Mass-Index

Keywords

Melanoma - Obesity - Body mass index

Publication History

Article published online:
01 September 2023

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