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Horm Metab Res 2023; 55(10): 692-700
DOI: 10.1055/a-2091-2072
Original Article: Endocrine Care

Geriatric Nutritional Risk Index and the Survival of Patients with Hepatocellular Carcinoma: A Meta-Analysis

Xingwen Xu
1   The Second Department of General Surgery, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China
,
Fugui Kang
1   The Second Department of General Surgery, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China
,
Nan Zhang
2   Intensive Care Unit, Lanzhou University First Hospital, Lanzhou, China
,
Yiming Niu
1   The Second Department of General Surgery, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China
,
Jintang Jia
1   The Second Department of General Surgery, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, China
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Abstract

Malnutrition is a risk factor of adverse clinical outcome in patients with cancer. Recent studies suggest that geriatric nutritional risk index (GNRI) could reflect the nutritional status in patients with various clinical conditions. The aim of the systematic review and meta-analysis was to evaluate the association between GNRI and survival of patients with hepatocellular carcinoma (HCC). Observational studies evaluating the association between pretreatment GNRI and survival of patients with HCC were obtained by search of PubMed, Web of Science, Embase, Wanfang, and CNKI databases. A random-effects model was used to pool the results after incorporating the potential influence of heterogeneity. Seven cohort studies including 2636 patients with HCC contributed to the meta-analysis. Pooled results showed that HCC patients with low pretreatment GNRI were associated with poor overall survival [hazard ratio (HR): 1.77, 95% confidence interval (CI): 1.32 to 2.37, p<0.001; I2=66%) and progression-free survival (HR: 1.62, 95% CI: 1.39 to 1.89, p<0.001; I2=0%) as compared to those with normal GNRI. Sensitivity analyses by excluding one study at a time showed similar results (p all<0.05). Subgroup analyses showed that the association between low pretreatment GNRI and poor survival of patients with HCC was not significantly affected by age of the patients, main treatment, cutoff of GNRI, or the follow-up durations. In conclusion, malnutrition indicated by a low pretreatment GNRI may be a risk factor of poor survival of patients with HCC.

Key words

geriatric nutritional risk index - malnutrition - hepatocellular carcinoma - survival - meta-analysis


Publication History

Received: 26 March 2023

Accepted after revision: 02 May 2023

Article published online:
29 June 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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