Acylation of Electron-Poor Alkenyl Sulfoxides: Diverse Transformations for the Synthesis of Polysubstituted Phenols and Functionalized Carbocycles

Xiaoyu Li; Qianyun Zhang; Yuanyuan Xie; Hongwei Zhou

doi:10.1055/a-2093-3233

Synthesis, Inhaltsverzeichnis

Synthesis 2023; 55(17): 2674-2682
DOI: 10.1055/a-2093-3233

paper

Acylation of Electron-Poor Alkenyl Sulfoxides: Diverse Transformations for the Synthesis of Polysubstituted Phenols and Functionalized Carbocycles

Xiaoyu Li

^aCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 341014, P. R. of China

^bCollege of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, 314001, P. R. of China

,

Qianyun Zhang

^bCollege of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, 314001, P. R. of China

,

Yuanyuan Xie∗

^aCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 341014, P. R. of China

^cKey Laboratory of Pharmaceutical Engineering of Zhejiang Province, Hangzhou, 310014, P. R. of China

,

Hongwei Zhou ∗

^bCollege of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, 314001, P. R. of China

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Abstract

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Abstract

A protocol with available starting materials and mild conditions was developed for the synthesis of polysubstituted phenols and functionalized carbocycles via acylation of electron-poor alkenyl sulfoxides. The plausible mechanism was investigated.

Key words

alkenyl sulfoxides - sulfonium ions - functionalized carbocycles - polysubstituted phenols - aromatization

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