HNF4α in Hepatocyte Health and Disease

Manasi Kotulkar; Dakota R. Robarts; Udayan Apte

doi:10.1055/a-2097-0660

Seminars in Liver Disease, Inhaltsverzeichnis

Semin Liver Dis 2023; 43(02): 234-244
DOI: 10.1055/a-2097-0660

Review Article

HNF4α in Hepatocyte Health and Disease

Manasi Kotulkar

¹Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas

,

Dakota R. Robarts

¹Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas

,

Udayan Apte

¹Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas

› Institutsangaben

Abstract

Hepatocyte nuclear factor 4 α (HNF4α) is a highly conserved member of the nuclear receptor superfamily expressed at high levels in the liver, kidney, pancreas, and gut. In the liver, HNF4α is exclusively expressed in hepatocytes, where it is indispensable for embryonic and postnatal liver development and for normal liver function in adults. It is considered a master regulator of hepatic differentiation because it regulates a significant number of genes involved in hepatocyte-specific functions. Loss of HNF4α expression and function is associated with the progression of chronic liver disease. Further, HNF4α is a target of chemical-induced liver injury. In this review, we discuss the role of HNF4α in liver pathophysiology and highlight its potential use as a therapeutic target for liver diseases.

Keywords

hepatocyte nuclear factor 4 α - liver development - hepatocyte differentiation - therapeutic target

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References
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