Magnetic Resonance Imaging–Based Radiomics Nomogram to Predict Intraoperative Hemorrhage of Placenta Previa

Yanli Lu; Liping Zhou; Xiaoyan Wang; Yongmei Li; Dali Chen; Yidong Gu; Yongfei Yue

doi:10.1055/a-2099-3809

American Journal of Perinatology, Table of Contents

Am J Perinatol 2024; 41(S 01): e2174-e2183
DOI: 10.1055/a-2099-3809

Original Article

Magnetic Resonance Imaging–Based Radiomics Nomogram to Predict Intraoperative Hemorrhage of Placenta Previa

Authors

Yanli Lu

¹Department of Radiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China
Liping Zhou

²Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China
Xiaoyan Wang

²Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China
Yongmei Li

²Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China
Dali Chen

²Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China
Yidong Gu

³Department of Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China
Yongfei Yue

²Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, People's Republic of China

Abstract

Objective Placenta previa (PP) is associated with intraoperative and postpartum hemorrhage, increased maternal morbidity and mortality. We aimed to develop a magnetic resonance imaging (MRI)-based nomogram to preoperative prediction of intraoperative hemorrhage (IPH) for PP.

Study Design A total of 125 PP pregnant women were divided into a training set (n = 80) and a validation set (n = 45). An MRI-based model was built for the classification of patients into IPH and non-IPH groups in a training set and a validation set. Multivariate nomograms were built according to radiomics features. Receiver operating characteristic (ROC) curve was used to assess the model. Predictive accuracy of nomogram were assessed by calibration plots and decision curve analysis.

Results In multivariate analysis, placenta position, placenta thickness, cervical blood sinus, and placental signals in the cervix were significantly independent predictors for IPH (all ps < 0.05). The MRI-based nomogram showed favorable discrimination between IPH and non-IPH groups. The calibration curve showed good agreement between the estimated and the actual probability of IPH. Decision curve analysis also showed a high clinical benefit across a wide range of probability thresholds. Area under the ROC curve was 0.918 (95% confidence interval [CI]: 0.857–0.979) in the training set and 0.866 (95% CI: 0.748–0.985) in the validation set by the combination of four MRI features.

Conclusion The MRI-based nomograms might be a useful tool for the preoperative prediction of IPH outcomes for PP. Our study enables obstetricians to perform adequate preoperative evaluation to reduce blood loss and cesarean hysterectomy.

Key Points

MRI is an important method for preoperative assessment of the risk of placenta previa.
MRI-based nomogram can assess the risk of intraoperative bleeding of placenta previa.
MRI is helpful for more comprehensive evaluation of placenta previa and adequate preoperative preparation.

Keywords

placenta previa - magnetic resonance imaging - intraoperative hemorrhage - nomogram

Full Text

References

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