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DOI: 10.1055/a-2103-7666
Von den klinischen Charakteristika zur sicheren Diagnose funktioneller neurologischer Bewegungsstörungen
From clinical characteristics to reliable diagnosis of functional neurological movement disorders
ZUSAMMENFASSUNG
Funktionelle neurologische Bewegungsstörungen gehören zu den häufigsten neurologischen Erkrankungen, führen oft zu einer erheblichen Einschränkung der Lebensqualität der Betroffenen und zu einer massiven finanziellen Belastung des Gesundheitssystems. Die Diagnose wird klinisch anhand positiver Diagnosekriterien gestellt, was apparative, kostenintensive Zusatzdiagnostik meist unnötig macht. Gehäuft kommt es allerdings zu einer erheblichen Verzögerung der Diagnose und damit verbunden, der Einleitung einer krankheitsspezifischen Therapie. In unserem Artikel möchten wir die Hauptpfeiler der klinischen Diagnose – die Inkongruenz und Inkonsistenz – die allen funktionellen Bewegungsstörungen gemeinsam ist, erläutern und darauf aufbauend die unterschiedlichen Subgruppen mit ihren individuellen klinischen Charakteristika und den dazugehörigen Untersuchungstechniken praxisnah erklären. Dies soll dazu beitragen, dass die Diagnose schnell und sicher gestellt werden kann. Außerdem ergeben sich aus den aufgeführten klinischen Charakteristika für die Therapie bedeutsame Strategien, z. B. die Modulation von Aufmerksamkeit, die in der Physio- und Psychotherapie zur Anwendung gebracht, aber vor allem durch die Patienten selbst genutzt werden können.
ABSTRACT
Functional neurological movement disorders are among the most common neurological diseases, often lead to a considerable reduction in the quality of life of those affected and to a massive financial burden on the healthcare system. The diagnosis is made clinically based on positive diagnostic criteria, which usually make additional, cost-intensive diagnostics unnecessary. However, there is often a considerable delay in diagnosis and initiation of disease-specific therapy. In our article, we would, therefore, like to explain the main pillars of clinical diagnosis – incongruence and inconsistency -, which are common to all functional movement disorders. Building on this, we will explain the different subgroups with their individual clinical characteristics and the associated examination techniques in a practical manner. This should help to ensure that the diagnosis can be made quickly and confidently. In addition, the clinical characteristics have strong implications for treatment strategies e. g., modulation of attention, which can be used in physiotherapy and psychotherapy, but above all by the patients themselves.
Schlüsselwörter
Funktionelle neurologische Bewegungsstörungen - klinische Charakteristika - positive Diagnosekriterien - Inkongruenz - Inkonsistenz - PhänomenologieKey words
Functional movement disorders - clinical characteristics - positive diagnostic criteria - incongruence - inconsistency - phenomenologyPublication History
Article published online:
02 August 2023
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Literatur
- 1 Stone J, Carson A, Duncan R. et al Who is referred to neurology clinics?--the diagnoses made in 3781 new patients. Clin Neurol Neurosurg 2010; 112: 747-751
- 2 Ahmad O, Ahmad KE. Functional neurological disorders in outpatient practice: An Australian cohort. J Clin Neurosci 2016; 28: 93-96
- 3 Lidstone SC, Costa-Parke M, Robinson EJ. et al Functional movement disorder gender, age and phenotype study: a systematic review and individual patient meta-analysis of 4905 cases. J Neurol Neurosurg Psychiatry 2022; 93: 609-616
- 4 Carson A, Stone J, Hibberd C. et al Disability, distress and unemployment in neurology outpatients with symptoms ‘unexplained by organic disease’. J Neurol Neurosurg Psychiatry 2011; 82: 810-813
- 5 Gelauff J, Stone J, Edwards M. et al The prognosis of functional (psychogenic) motor symptoms: a systematic review. J Neurol Neurosurg Psychiatry 2014; 85: 220-226
- 6 de Liege A, Carle G, Hingray C. et al Functional Neurological Disorders in the medical education: An urgent need to fill the gaps. Rev Neurol (Paris) 2022; 178: 788-795
- 7 Gasca-Salas C, Lang AE. Neurologic diagnostic criteria for functional neurologic disorders. Handb Clin Neurol 2016; 139: 193-212
- 8 Hess CW, Espay AJ, Okun MS. Inconsistency and incongruence: the two diagnostic pillars of functional movement disorder. Lancet 2022; 400: 328
- 9 Espay AJ, Aybek S, Carson A. et al Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders. JAMA Neurol 2018; 75: 1132-1141
- 10 Aybek S, Lidstone SC, Nielsen G. et al What Is the Role of a Specialist Assessment Clinic for FND? Lessons From Three National Referral Centers. J Neuropsychiatry Clin Neurosci 2020; 32: 79-84
- 11 Tomic A, Jecmenica Lukic M, Petrovic I. et al Changes of Phenotypic Pattern in Functional Movement Disorders: A Prospective Cohort Study. Front Neurol 2020; 11: 582215
- 12 Ganos C, Aguirregomozcorta M, Batla A. et al Psychogenic paroxysmal movement disorders--clinical features and diagnostic clues. Parkinsonism Relat Disord 2014; 20: 41-46
- 13 Stone J, Burton C, Carson A. Recognising and explaining functional neurological disorder. BMJ 2020; 371: m3745
- 14 Schwingenschuh P, Deuschl G. Functional tremor. Handb Clin Neurol 2016; 139: 229-233
- 15 Aybek S, Perez DL. Diagnosis and management of functional neurological disorder. BMJ 2022; 376: o64
- 16 Laub HN, Dwivedi AK, Revilla FJ. et al Diagnostic performance of the “Huffing and Puffing” sign in psychogenic (functional) movement disorders. Mov Disord Clin Pract 2015; 02: 29-32
- 17 Ganos C, Parees I, Bhatia KP. Effort-Related Behaviors in Charcot’s Lectures on Hysteria. Mov Disord Clin Pract 2015; 02: 201-202
- 18 Furuya S, Ishimaru R, Nagata N. Factors of choking under pressure in musicians. PLoS One 2021; 16: e0244082
- 19 Wulf G. Attentional focus and motor learning: a review of 15 years. International Review of sport and Exercise psychology 2013; 06: 77-104
- 20 Linden SC. Triggers and clinical presentations of functional neurological disorders: lessons from world war 1. Eur Neurol 2020; 83: 174-181
- 21 Ganos C, Edwards MJ, Bhatia KP. Posttraumatic functional movement disorders. Handb Clin Neurol 2016; 139: 499-507
- 22 Geroin C, Stone J, Camozzi S. et al Triggers in functional motor disorder: a clinical feature distinct from precipitating factors. J Neurol 2022; 269: 3892-3898
- 23 Mishra A, Pandey S. Functional Neurological Disorders: Clinical Spectrum, Diagnosis, and Treatment. Neurologist 2022; 27: 276-289
- 24 Pringsheim T, Edwards M. Functional movement disorders: Five new things. Neurology Clinical practice 2017; 07: 141-147
- 25 Edwards MJ, Adams RA, Brown H. et al A Bayesian account of ‘hysteria’. Brain 2012; 135: 3495-3512
- 26 Tinazzi M, Geroin C, Erro R. et al Functional motor disorders associated with other neurological diseases: Beyond the boundaries of “organic” neurology. Eur J Neurol 2021; 28: 1752-1758
- 27 Wissel BD, Dwivedi AK, Merola A. et al Functional neurological disorders in Parkinson disease. J Neurol Neurosurg Psychiatry 2018; 89: 566-571
- 28 Ganos C, Sarva H, Kurvits L. et al Clinical Practice Patterns in Tic Disorders Among Movement Disorder Society Members. Tremor Other Hyperkinet Mov 2021; 11: 43
- 29 Walzl D, Solomon AJ, Stone J. Functional neurological disorder and multiple sclerosis: a systematic review of misdiagnosis and clinical overlap. J Neurol 2022; 269: 654-663
- 30 Aybek S, Chan A. The borderland of multiple sclerosis and functional neurological disorder: A call for clinical research and vigilance. Eur J Neurol 2023; 30: 3-8
- 31 Lidstone SC, Nassif W, Juncos J. et al Diagnosing functional neurological disorder: seeing the whole picture. CNS Spectr 2020: 1-8
- 32 American Psychiatric Association D, Association AP. Diagnostic and statistical manual of mental disorders: DSM-5. American psychiatric association. Washington, DC 2013
- 33 Patron VG, Rustomji Y, Yip C. et al Psychiatric Comorbidities in Functional Neurologic Symptom Disorder. Pract Neurol 2022; 21: 71-75
- 34 Thenganatt MA, Jankovic J. Psychogenic (functional) parkinsonism. Handb Clin Neurol 2016; 139: 259-262
- 35 Pringsheim T, Ganos C, Nilles C. et al European Society for the Study of Tourette Syndrome 2022 criteria for clinical diagnosis of functional tic-like behaviours: International consensus from experts in tic disorders. Eur J Neurol 2023; 30: 902-910
- 36 Ganos C, Martino D, Espay AJ. et al Tics and functional tic-like movements: Can we tell them apart?. Neurology 2019; 93: 750-758
- 37 Van der Stouwe A, Elting J, Van der Hoeven J. et al How typical are ‘typical’tremor characteristics? Sensitivity and specificity of five tremor phenomena. Parkinsonism Relat Disord 2016; 30: 23-28
- 38 Deuschl G, Raethjen J, Kopper F. et al The diagnosis and physiology of psychogenic tremor. Psychogenic movement disorders: neurology and neuropsychiatry Philadelphia: Lippincott Williams & Wilkins 2005: 265-273
- 39 Stamelou M, Saifee TA, Edwards MJ. et al Psychogenic palatal tremor may be underrecognized: reappraisal of a large series of cases. Mov Disord 2012; 27: 1164-1168
- 40 Roper LS, Saifee TA, Parees I. et al How to use the entrainment test in the diagnosis of functional tremor. Pract Neurol 2013; 13: 396-398
- 41 Schwingenschuh P, Espay AJ. Functional tremor. J Neurol Sci 2022; 435: 120208
- 42 Park JE, Maurer CW, Hallett M. The “Whack-a-Mole” Sign in Functional Movement Disorders. Mov Disord Clin Pract 2015; 02: 286-288
- 43 Kumru H, Valls-Sole J, Valldeoriola F. et al Transient arrest of psychogenic tremor induced by contralateral ballistic movements. Neurosci Lett 2004; 370: 135-139
- 44 Mainka T, Ganos C. Normale motorische Bewegungsabläufe wiedererlernen. InFo Neurologie + Psychiatrie 2020; 22: 32-41
- 45 Baizabal-Carvallo JF, Alonso-Juarez M, Jankovic J. Functional gait disorders, clinical phenomenology, and classification. Neurol Sci 2020; 41: 911-915
- 46 Nonnekes J, Ruzicka E, Serranova T. et al Functional gait disorders: A sign-based approach. Neurology 2020; 94: 1093-1099
- 47 Okun MS, Rodriguez RL, Foote KD. et al The “chair test” to aid in the diagnosis of psychogenic gait disorders. The neurologist 2007; 13: 87-91
- 48 Lempert T, Brandt T, Dieterich M. et al How to identify psychogenic disorders of stance and gait. A video study in 37 patients. J Neurol 1991; 238: 140-146
- 49 Goetz CG, Vittal P, Maldonado J. How Do I Test for Postural Stability?. Mov Disord Clin Pract 2014; 01: 144
- 50 Boogaarts HD, Abdo WF, Bloem BR. “Recumbent” gait: relationship to the phenotype of “astasia-abasia”?. Mov Disord 2007; 22: 2121-2122
- 51 Scura D, Munakomi S.. Tinetti Gait and Balance Test. Treasure Island (FL): StatPearls; 2022
- 52 Geroin C, Nonnekes J, Erro R. et al Shoulder-Touch test to reveal incongruencies in persons with functional motor disorders. Eur J Neurol 2022; 29: 3508-3512
- 53 Hoover C. A new sign for the detection of malingering and functional paresis of the lower extremities. J Am Med Assoc 1908; 51: 746-747
- 54 Tinazzi M, Simonetto S, Franco L. et al Abduction finger sign: a new sign to detect unilateral functional paralysis of the upper limb. Movement disorders 2008; 23: 2415-2419
- 55 Sonoo M. Abductor sign: a reliable new sign to detect unilateral non-organic paresis of the lower limb. J Neurol Neurosurg Psychiatry 2004; 75: 121-125
- 56 Yugue I, Shiba K, Ueta T. et al A new clinical evaluation for hysterical paralysis. Spine 2004; 29: 1910-1913 discussion 1913
- 57 Daum C, Gheorghita F, Spatola M. et al Interobserver agreement and validity of bedside ‘positive signs’ for functional weakness, sensory and gait disorders in conversion disorder: a pilot study. J Neurol Neurosurg Psychiatry 2015; 86: 425-430
- 58 Daum C, Aybek S. Validity of the “Drift without pronation” sign in conversion disorder. BMC Neurol 2013; 13: 31
- 59 Schrag A, Trimble M, Quinn N. et al The syndrome of fixed dystonia: an evaluation of 103 patients. Brain 2004; 127: 2360-2372
- 60 Munhoz RP, Lang AE. Gestes antagonistes in psychogenic dystonia. Mov Disord 2004; 19: 331-332
- 61 Stamey W, Jankovic J. The other Babinski sign in hemifacial spasm. Neurology 2007; 69: 402-404
- 62 Frucht L, Perez DL, Callahan J. et al Functional Dystonia: Differentiation From Primary Dystonia and Multidisciplinary Treatments. Front Neurol 2020; 11: 605262
- 63 Baker JH, Silver JR. Hysterical paraplegia. J Neurol Neurosurg Psychiatry 1987; 50: 375-382
- 64 Lang AE. Psychogenic dystonia: a review of 18 cases. Can J Neurol Sci 1995; 22: 136-143
- 65 Ganos C, Edwards MJ, Bhatia KP. The Phenomenology of Functional (Psychogenic) Dystonia. Mov Disord Clin Pract 2014; 01: 36-44
- 66 Rigas A, Mainka T, Pringsheim T. et al Distinguishing functional from primary tics: a study of expert video assessments. J Neurol Neurosurg Psychiatry 2023