Comparison of Exercise Capacity, Physical Activity Level and
                    Peripheral Muscle Strength in Systemic Lupus Erythematosus Patients with Healthy
                    Individuals

Fulden Sari; Selin Bayram; Deran Oskay; Abdurrahman Tufan

doi:10.1055/a-2106-7129

Aktuelle Rheumatologie, Table of Contents

Aktuelle Rheumatologie 2024; 49(04): 264-270
DOI: 10.1055/a-2106-7129

Original Article

Comparison of Exercise Capacity, Physical Activity Level and Peripheral Muscle Strength in Systemic Lupus Erythematosus Patients with Healthy Individuals

Vergleich von Belastungsfähigkeit, körperlichem Aktivitätslevel und peripherer Muskelstärke von Patienten mit Systemischem Lupus erythematodes und gesunden Individuen

Fulden Sari

¹Department of Physiotherapy and Rehabilitation, Bingöl Üniversitesi, Bingol, Turkey

,

Selin Bayram

²Department of Physiotherapy and Rehabilitation, Gazi University, Ankara, Turkey

,

Deran Oskay

²Department of Physiotherapy and Rehabilitation, Gazi University, Ankara, Turkey

,

Abdurrahman Tufan

³Rheumatology, National Human Genome Research Institute, Bethesda, United States

› Author Affiliations

Abstract

Background This study investigated physical activity, peripheral muscle strength, exercise capacity, sleep, fatigue, anxiety and depression in patients with systemic lupus erythematosus (SLE).

Material and Methods Twenty-six patients with SLE, median age 32.5 (25–43) years, and 29 healthy individuals, median age 30 (23–32) years, were included. Exercise capacity (6-minute walk test (6MWT)), peripheral muscle strength (dynamometer), physical activity (Mi Band 4 smart band), fatigue (Fatigue Severity Scale (FSS)), anxiety and depression (Hospital Anxiety Depression scale (HAD)), quality of life (SLE-specific QOL scale (SLEQoL)) and sleep (Pittsburgh Sleep Quality Index (PSQI)) were assessed.

Results Demographic characteristics were similar in both groups. 6MWT distance, peripheral muscle strength, physical activity level, SLEQoL and PSQI scores were significantly lower, while FSS and HAD scores were higher in patients with SLE (p<0.05). Moreover, pre-test and post-test heart rates, dyspnea and fatigue severity scores were higher in patients with SLE than in healthy individuals (p<0.05).

Conclusion Patients with SLE had lower exercise capacity, muscle strength, physical activity, quality of life and sleep quality, along with more common fatigue, anxiety and depression. Strategies need to be developed to improve these symptoms in patients with SLE for a favourable outcome.

Key words

fatigue - exercise - sleep - depression - anxiety

Schlüsselwörter

Müdigkeit - Bewegung - Schlaf - Depression - Angst

Full Text

References

References
1 Wallace DJ, Hahn B. Dubois’ lupus erythematosus. Lippincott Williams and Wilkins; 2007
2 Collins R, Turner R, Nomeir A. et al. Cardiopulmonary manifestations of systemic lupus erythematosus. J Rheumatol 1978; 5: 299-306
3 Margiotta DPE, Basta F, Dolcini G. et al. Physical activity and sedentary behavior in patients with systemic lupus erythematosus. PloS one 2018; 13: e0193728
4 Cheung SM, Keenan K, Senn N. et al. Metabolic and Structural Skeletal Muscle Health in Systemic Lupus Erythematosus–Related Fatigue: A Multimodal Magnetic Resonance Imaging Study. Arthritis Care Res 2019; 71: 1640-1646
5 Tench C, Bentley D, Vleck V. et al. Aerobic fitness, fatigue, and physical disability in systemic lupus erythematosus. J Rheumatol 2002; 29: 474-481
6 Pinto AJ, Miyake CN, Benatti FB. et al. Reduced aerobic capacity and quality of life in physically inactive patients with systemic lupus erythematosus with mild or inactive disease. Arthritis Care Res 2016; 68: 1780-1786
7 Pinto AJ, Benatti FB, Roschel H. et al. Poor muscle strength and function in physically inactive childhood-onset systemic lupus erythematosus despite very mild disease. Rev Bras Reumatol Engl Ed 2016; 56: 509-514
8 Bertsias G, Ioannidis J, Aringer M. et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis 2010; 69: 2074-2082
9 Andrews JS, Trupin L, Schmajuk G. et al. Muscle strength, muscle mass, and physical disability in women with systemic lupus erythematosus. Arthritis Care Res 2015; 67: 120-127
10 Giang DW. Systemic lupus erythematosus and depression. Cogn Behav Neurol 1991; 4: 78-82
11 Jump RL, Robinson ME, Armstrong AE. et al. Fatigue in systemic lupus erythematosus: contributions of disease activity, pain, depression, and perceived social support. J Rheumatol 2005; 32: 1699-1705
12 Chung W, Lin C, Kao C. Association of systemic lupus erythematosus and sleep disorders: a nationwide population-based cohort study. Lupus 2016; 25: 382-388
13 Gamaldo CE, Shaikh AK, McArthur JC. The sleep-immunity relationship. Neurol Clin 2012; 30: 1313-1343
14 Inoue M, Shiozawa K, Yoshihara R. et al. Predictors of poor sleep quality in patients with systemic lupus erythematosus. Clin Rheumatol 2017; 36: 1053-1062
15 Gladman DD, Ibanez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002; 29: 288-291
16 de la Casa Pérez A, Latorre Román PÁ, Muñoz Jiménez M. et al. Is the Xiaomi Mi Band 4 an Accuracy Tool for Measuring Health-Related Parameters in Adults and Older People? An Original Validation Study. Int J Environ Res Public Health 2022; 19: 1593
17 Holland AE, Spruit MA, Troosters T. et al. An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur Respir J 2014; 44: 1428-1446
18 Andrews AW, Thomas MW, Bohannon RW. Normative values for isometric muscle force measurements obtained with hand-held dynamometers. Phys Ther 76: 248-259
19 Armutlu K, Korkmaz NC, Keser I. et al. The validity and reliability of the Fatigue Severity Scale in Turkish multiple sclerosis patients. Int J Rehabil Res 1996; 30: 81-85
20 Aydemir Ö, Guvenir T, Kuey L. et al. Validity and reliability of Turkish version of hospital anxiety and depression scale. Turk Psikiyatri Derg 1997; 8: 280-287
21 Leong K, Kong K, Thong B. et al. Development and preliminary validation of a systemic lupus erythematosus-specific quality-of-life instrument (SLEQOL). Rheumatology 2005; 44: 1267-1276
22 Agargun M, Kara H, Anlar O. The reliability and validity of Turkish version of Pittsburgh Sleep Quality Index. Turk Psikiyatri Derg 1996; 7: 107-115
23 Forte S, Carlone S, Vaccaro F. et al. Pulmonary gas exchange and exercise capacity in patients with systemic lupus erythematosus. J Rheumatol 1999; 26: 2591-2594
24 Sakauchi M, Matsumura T, Yamaoka T. et al. Reduced muscle uptake of oxygen during exercise in patients with systemic lupus erythematosus. J Rheumatol 1995; 22: 1483-1487
25 Balsamo S, Nascimento DdC, Tibana RA. et al. The quality of life of patients with lupus erythematosus influences cardiovascular capacity in 6-minute walk test. Rev Bras Reumatol 2013; 53: 81-87
26 Leite MA, Pereira MC, Costallat LTL. et al. Evaluation of respiratory impairment in patients with systemic lupus erythematosus with the six-minute walk test. Rev Bras Reumatol 2014; 54: 192-199
27 Eriksson K, Svenungsson E, Karreskog H. et al. Physical activity in patients with systemic lupus erythematosus and matched controls. Scand J Rheumatol 2012; 41: 290-297
28 Legge A, Blanchard C, Hanly JG. Physical activity and sedentary behavior in patients with systemic lupus erythematosus and rheumatoid arthritis. Open Access Rheumatol 2017; 9: 191-200
29 Xie J, Wen D, Liang L. et al. Evaluating the validity of current mainstream wearable devices in fitness tracking under various physical activities: comparative study. JMIR Mhealth Uhealth 2018; 6: e9754
30 Stockton KA, Kandiah DA, Paratz JD. et al. Fatigue, muscle strength and vitamin D status in women with systemic lupus erythematosus compared with healthy controls. Lupus 2012; 21: 271-278