Zur Koinzidenz von Normaldruckhydrocephalus und Alzheimer-Demenz: therapeutische Implikationen und offene Fragen

Zusammenfassung

Der Normaldruckhydrocephalus (NPH) ist im höheren Lebensalter häufig, eine klinische Unterversorgung von Patienten wahrscheinlich. Nicht selten besteht eine komorbide Alzheimererkrankung. Die häufige Koinzidenz lässt pathophysiologische Überschneidungen vermuten, welche bislang aber unzureichend verstanden sind. Cerebrale Komorbiditäten scheinen das therapeutische Ansprechen auf eine ventrikuloperitoneale Shuntversorgung erheblich zu beeinflussen. Ihre Würdigung im diagnostischen Prozess ist daher von großer Bedeutung, um dem häufig hochvulnerablen Patientenklientel wenig erfolgsversprechende operative Prozeduren zu ersparen.

Abstract

Normal pressure hydrocephalus (NPH) is prevalent in aging patient populations. Despite its clinical relevance, many patients with NPH may not receive adequate treatment. Because of the frequency of Alzheimer`s disease in these patients, there could be overlapping pathophysiological mechanisms that are as yet incompletely understood. Cerebral comorbidities seem to have negative effects on therapeutic response to ventriculoperitoneal shunting. In order to avoid unnecessary and unsuccessful surgery in highly vulnerable elderly patients, they have to be taken into consideration in the diagnostic process.

Schlüsselwörter

Alzheimer-Demenz - Normaldruckhydrocephalus - Liquorablassversuch

Key words

Alzheimer’s disease - normal pressure hydrocephalus - spinal tap test

Publikationsverlauf

Eingereicht: 07. Juni 2022

Angenommen: 01. Juni 2023

Artikel online veröffentlicht:
06. Juli 2023

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