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DOI: 10.1055/a-2110-0142
Neuroendokrines Karzinom der Gallenblase als seltene Ursache für Meläna und Hämatemesis beim Hund
Neuroendocrine carcinoma of the gallbladder as a rare cause for melena and hematemesis in dogs
Zusammenfassung
Ein 9-jähriger männlicher Malinois wurde zur weiteren Evaluation akuter Meläna und Hämatemesis sowie seit einem Monat anhaltenden Gewichtsverlusts vorgestellt. Klinisch präsentierte sich der Patient von geringgradig reduziertem Allgemeinbefinden. Die Blutuntersuchung ergab eine geringgradige nicht-regenerative Anämie sowie eine geringgradige Alaninaminotransferase (ALT)-Erhöhung. Ultrasonographisch bestand der Verdacht auf eine frühe Mukozele. Die medikamentöse Therapie mit Gastroprotektiva führte nicht zur klinischen Besserung und der Hund entwickelte eine progressive Anämie. Die Gastroduodenoskopie verlief ohne besonderen Befund. Aufgrund anhaltender Symptomatik wurde eine explorative Laparotomie durchgeführt. Dabei wurde eine ulzerierte blutende Masse am Gallenblasenhals detektiert. Die histopathologische Untersuchung ergab ein neuroendokrines Karzinom. Hinweise auf eine Mukozele fanden sich histopathologisch nicht. Meläna und Hämatemesis waren postoperativ nicht mehr nachweisbar und 13 Monate nach Cholezystektomie war der Hund weiterhin klinisch symptomfrei. Neuroendokrine Karzinome der Gallenblase sollten als seltene Ursachen für Meläna und Hämatemesis beim Hund betrachtet werden.
Abstract
A 9-year-old male Malinois was presented for further workup of acute melena, hematemesis and chronic weight loss for a duration of one month. Clinically, the patient presented with a mildly reduced general condition. Blood tests revealed mild non-regenerative anemia as well as a mild elevation of alanine aminotransferase (ALT). Ultrasonography showed signs of an early mucocele. Treatment with gastroprotectants failed to lead to clinical improvement and the dog developed progressive anemia. Gastroduodenoscopy was unremarkable. Due to persistent clinical signs, exploratory laparotomy was performed. An ulcerated bleeding mass was detected at the gallbladder neck. Histopathological examination led to the diagnosis of a neuroendocrine carcinoma. There was no evidence of a mucocele on histopathology. Melena and hematemesis subsided postoperatively and 13 months after cholecystectomy, the dog remains without clinical signs. Neuroendocrine carcinomas of the gallbladder should be considered as a rare cause of melena and hematemesis in dogs.
Publication History
Received: 05 December 2023
Accepted: 11 April 2023
Article published online:
11 August 2023
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Literatur
- 1 Patnaik AK, Lieberman PH, Hurvitz AI. et al. Canine hepatic carcinoids. Vet Pathol 1981; 18: 445-453
- 2 Morrell CN, Volk MV, Mankowski JL. A carcinoid tumor in the gallbladder of a dog. Vet Pathol 2002; 39: 756-758
- 3 Lippo NJ, Williams JE, Brawer RS. et al. Acute hemobilia and hemocholecyst in 2 dogs with gallbladder carcinoid. J Vet Intern Med 2008; 22: 1249-1252
- 4 Birettoni F, Porciello F, Caivano D. et al. Primary neuroendocrine carcinoma of the gallbladder in a dog. Vet Res Commun 2008; 32: S239-S242
- 5 Bhandal J, Head LL, Francis DA. et al. Use of color flow Doppler ultrasonography to diagnose a bleeding neuroendocrine tumor in the gallbladder of a dog. J Am Vet Med Assoc 2009; 235: 1326-1329
- 6 O'Brien KM, Bankoff BJ, Rosenstein PK. et al. Clinical, histopathologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma. J Vet Diagn Invest 2021; 33: 294-299
- 7 Willard MD, Dunstan RW, Faulkner J. Neuroendocrine carcinoma of the gallbladder in a dog (Abstract). J Am Vet Med Assoc 1988; 192: 926-928
- 8 Parkanzky M, Grimes J, Schmiedt C. et al. Long-term survival of dogs treated for gallbladder mucocele by cholecystectomy, medical management, or both. J Vet Intern Med 2019; 33: 2057-2066
- 9 Sykes GP, Cooper BJ. Canine intestinal carcinoids. Vet Pathol 1982; 19: 120-131
- 10 Chu H, Shi Y, Liu J. et al. Update in clinical management for gallbladder neuroendocrine carcinoma. Medicine (Baltimore) 2021; 100: e25449
- 11 Churcher RK. Hepatic carcinoid, hypercortisolism and hypokalaemia in a dog. Aust Vet J 1999; 77: 641-645
- 12 Tappin S, Brown P, Ferasin L. An intestinal neuroendocrine tumour associated with paroxysmal ventricular tachycardia and melaena in a 10-year-old boxer. J Small Anim Pract 2008; 49: 33-37
- 13 Bargellini P, Orlandi R, Paloni C. et al. Contrast-enhanced ultrasound complements two-dimensional ultrasonography in diagnosing gallbladder diseases in dogs. Vet Radiol Ultrasound 2018; 59: 345-356
- 14 Brand EM, Lim CK, Heng HG. et al. Computed tomographic features of confirmed gallbladder pathology in 34 dogs. Vet Radiol Ultrasound 2020; 61: 667-679
- 15 Nishigami T, Yamada M, Nakasho K. et al. Carcinoid tumor of the gall bladder. Intern Med 1996; 35: 953-956
- 16 Patnaik AK, Hurvitz AI, Johnson GF. Canine intestinal adenocarcinoma and carcinoid. Vet Pathol 1980; 17: 149-63
- 17 Sako T, Uchida E, Okamoto M. et al. Immunohistochemical evaluation of a malignant intestinal carcinoid in a dog. Vet Pathol 2003; 40: 212-215
- 18 Rindi G, Mete O, Uccella S. et al. Overview of the 2022 WHO Classification of Neuroendocrine Neoplasms. Endocr Pathol 2022; 33: 115-154
- 19 Freis P, Graillot E, Rousset P. et al. Prognostic factors in neuroendocrine carcinoma: biological markers are more useful than histomorphological markers. Sci Rep 2017; 7: 40609
- 20 Trigo FJ, Thompson H, Breeze RG. et al. The pathology of liver tumours in the dog. J Comp Pathol 1982; 92: 21-39
- 21 Patnaik AK, Hurvitz AI, Lieberman PH. et al. Canine bile duct carcinoma. Vet Pathol 1981; 18: 439-444
- 22 Strafuss AC. Bile duct carcinoma in dogs. J Am Vet Med Assoc 1976; 169: 429