Method for the Synthesis of 2H-1,4-Benzoxazin-3-(4H)-ones via Ligand-Free Copper-Catalyzed Cascade Reaction

Abstract

An efficient method for the synthesis of 2H-1,4-benzoxazin-3-(4H)-ones via ligand-free copper-catalyzed cascade reaction of substituted chloroacetamides with 2-halophenols has been developed for the first time. Some of the issues typically encountered during the synthesis of 2H-1,4-benzoxazin-3-(4H)-ones, including adding noble metals and ligands, poor substrate scope, have been addressed using this newly developed ligand-free copper-catalyzed cascade reaction.

Key words

copper - cross-coupling - ligand-free - Ullmann reaction - 2H-1,4-benzoxazin-3-(4H)-ones

Publication History

Received: 30 April 2023

Accepted after revision: 14 June 2023

Accepted Manuscript online:
14 June 2023

Article published online:
17 July 2023

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