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Horm Metab Res 2023; 55(11): 794-800
DOI: 10.1055/a-2111-3821
Original Article: Endocrine Research

Aberrantly Expressed lncRNA LINC00847 May Serve as a Promising Prognostic Factor for Thyroid Cancer

Guoli Hei‡
1   Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China
,
Yan Yu‡
2   Outpatient, Huai’an No 4 People’s Hospital, Huai’an, China
,
Yang Wu
3   General Surgery (Thyroid Gland/Blood Vessel), The First People’s Hospital of Neijiang, Neijiang, China
,
Jianyuan Huang
3   General Surgery (Thyroid Gland/Blood Vessel), The First People’s Hospital of Neijiang, Neijiang, China
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Abstract

Thyroid cancer is a tumor that occurs in the head and neck, which originates from the thyroid follicular epithelial cells. The current research is discussed and elaborated from the perspective of molecular prognostic biomarkers to gain a deeper understanding of the molecular mechanism of thyroid cancer and to provide more effective treatment and prognostic methods for patients. Thyroid cancer patients were explored from histological, cellular and clinical levels. Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression of LINC00847 and miR-146b-5p in the tissues and cells of the subjects. Cell growth and thyroid cancer progression were determined by the cell counting kit-8 (CCK-8) and transwell assays. The LINC00847 sponge miR-146b-5p was assessed by bioinformatics tools and luciferase reporter assay, and the Kaplan–Meier method and multivariate Cox regression analysis suggested the prognostic value of high expression of LINC00847. In thyroid cancer tissues and cells, the expression of LINC00847 was decreased. Overexpression of LINC00847 remarkably inhibited the proliferation level, migration ability and invasion ability of thyroid cancer cells. Besides, miR-146b-5p was upregulated in thyroid cancer tissues and cells. It was confirmed that LINC00847 targeting miR-146b-5p had a regulatory effect on the progression of thyroid cancer, and LINC00847 was negatively correlated with miR-146b-5p. LINC00847 may be considered a meaningful prognostic marker to influence tumor growth through sponge miR-146b-5p, which provides a new basis for the prognosis and treatment of thyroid cancer.

Key words

thyroid cancer - lncRNA LINC00847 - miR-146b-5p - prognostic factor


Publikationsverlauf

Eingereicht: 08. März 2023

Angenommen nach Revision: 07. Juni 2023

Artikel online veröffentlicht:
06. Juli 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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