Synthesis of the Key Saccharide Fragments of the Glucuronic Acid-Containing Repeat Unit of Pentosan Polysulfate, a Heparin Sulfate Mimetic

Martin G. Banwell; Sarah Marshall; Jas S. Ward; Brett D. Schwartz

doi:10.1055/a-2126-0346

SynOpen, Table of Contents

CC BY 4.0 · SynOpen 2023; 07(03): 381-393
DOI: 10.1055/a-2126-0346

paper

Synthesis of the Key Saccharide Fragments of the Glucuronic Acid-Containing Repeat Unit of Pentosan Polysulfate, a Heparin Sulfate Mimetic

Authors

Martin G. Banwell ∗

^aInstitute for Advanced and Applied Chemical Synthesis, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632, P. R. of China
Sarah Marshall

^bResearch School of Chemistry, The Australian National University, Canberra, ACT 2601, Australia
Jas S. Ward

^bResearch School of Chemistry, The Australian National University, Canberra, ACT 2601, Australia
Brett D. Schwartz∗

^bResearch School of Chemistry, The Australian National University, Canberra, ACT 2601, Australia

Abstract

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Abstract

Suitably protected mono- and di-saccharide residues associated with the glucuronic acid-containing repeat unit related to pentosan polysulfate have been prepared. The stereo-controlled coupling, using trichloroacetimidate chemistry, of certain of these is also described and the structure of a disaccharide so-formed has been confirmed by single-crystal X-ray analysis.

Key Words

heparanase - mimetic - pentosan polysulfate (PPS) - trichloroacetimidate - xylose

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References

References and Notes

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