Chromatische Pupillometrie – ein neuer Weg zur funktionellen Glaukomdiagnostik?

Zusammenfassung

Die chromatische Pupillometrie erlaubt die Quantifizierung der photorezeptorvermittelten (extrinsischen) und der melanopsinvermittelten (intrinsischen) Antwort der intrinsisch-photosensitiven retinalen Ganglienzellen (ipRGCs). Diese kleine Subpopulation der Ganglienzellen wird beim Glaukom ebenfalls geschädigt, und somit ist die chromatische Pupillometrie für die Glaukomdiagnostik potenziell interessant. Die bisherigen Studien zeigen sowohl eine Verminderung der phasischen Antwort als auch der tonischen Antwort beim Glaukom. Die diagnostische Wertigkeit unterschied sich abhängig von der verwendeten Technik und dem Studiendesign. Der vorliegende Artikel soll vor allem die Grundlagen der chromatischen Pupillometrie und die potenziellen Anwendungen beim Glaukom darstellen.

Schlüsselwörter

Glaukom - Pupillometrie - retinale Ganglienzellen - Neuroophthalmologie

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