Abstract
Objective To evaluate the impact of increased Activated Protein C (APC)
resistance, decreased antithrombin III activity and hypocomplementemia on the
pregnancy outcomes of the patients with methylentetrahydrofolate reductase
(MTHFR) polymorphisms.
Methods This study was composed of 83 pregnancies with MTHFR
polymorphisms. Increased APC resistance, decreased antithrombin III activity and
hypocomplementemia were accepted as risk factors for poor gestational
outcome.
Results Having at least one risk factor resulted in significantly higher
rates of “APGAR score of<7” at the first ten minutes
(p=0.009). Composite adverse outcome rate was also higher in patients
with at least one of the defined risk factors despite lack of statistical
significance (p=0.241). Rate of newborn with an “APGAR score
of<7” at first ten minutes was significantly higher at patients
with hypocomplementemia (p=0.03).
Conclusion Hypocomplementemia is a risk factor for poor gestational
outcome in pregnancies with MTHFR polymorphisms.
Key words pregnancy - mthfr polymorphisms - Activated Protein C resistance - Antithrombin III activity - hypocomplementemia