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Synthesis 2023; 55(23): 4020-4024
DOI: 10.1055/a-2145-5470
DOI: 10.1055/a-2145-5470
paper
Efficient Syntheses of (S)- and (R)-β-Proline
Authors acknowledge NSERC for funding grant #RGPIN-2020-05461.
Abstract
A facile, efficient, and economical synthesis of both β-proline enantiomers starting from trans-4-hydroxy-l-proline is reported. Light-promoted radical Barton decarboxylation and nitrile introduction at C4 followed by hydrolysis gives the desired products in high optical purity. These routes should be of interest to those seeking economical access to β-proline for multiple applications.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2145-5470
- Supporting Information
Publication History
Received: 15 May 2023
Accepted after revision: 31 July 2023
Accepted Manuscript online:
31 July 2023
Article published online:
14 September 2023
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