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DOI: 10.1055/a-2150-2291
Moderately severe acute pancreatitis after snake bite: a case report from Southern China
Mäßig schwere akute Pankreatitis nach Schlangenbiss: Ein Fallbericht aus Südchina Supported by: The project of the Jiangxi Department of Science and Technology 20202BBGL73109Supported by: the program of Jiangxi Clinical Research Center for Gastroenterology 20201ZDG02007
Supported by: National Natural Science Foundation of China 82160694
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Abstract
Venomous snakebites are not rare worldwide, and this is also the situation in the mountainous regions of southern China, where they pose a serious health risk to the local population. Snake venom usually causes a variety of clinical symptoms, such as local pain and swelling, systemic coagulation system abnormalities, and shock, but rarely leads to acute pancreatitis. In this report, we presented a rare case of moderately severe acute pancreatitis caused by snake venom even after prompt antivenom treatment. The patient was relieved, obviously, with effective treatment of acute pancreatitis and was discharged without severe complications. Although acute pancreatitis after snake bite is a rarity, its serious complications and lethality still deserve our utmost attention, and timely and standardized treatment of acute pancreatitis is needed in addition to antivenom treatment.
Zusammenfassung
Venöse Schlangenbisse sind weltweit keine Seltenheit, und das ist auch die Situation in den Bergregionen Südchinas, wo sie ein ernstes Gesundheitsrisiko für die lokale Bevölkerung darstellen. Schlangengift verursacht in der Regel eine Vielzahl von klinischen Symptomen wie lokale Schmerzen und Schwellungen, systemische Gerinnungssystemanomalien und Schock, führt aber selten zu akuter Pankreatitis. In diesem Bericht stellen wir einen seltenen Fall einer mittelschweren akuten Pankreatitis vor, die durch Schlangengift selbst nach sofortiger Antigiftbehandlung verursacht wird. Der Patient besserte sich offensichtlich mit einer wirksamen Behandlung der akuten Pankreatitis und wurde ohne schwere Komplikationen entlassen. Obwohl akute Pankreatitis nach Schlangenbiss eine Seltenheit ist, verdienen ihre schwerwiegenden Komplikationen und Letalität immer noch unsere größte Aufmerksamkeit und eine rechtzeitige und standardisierte Behandlung der akuten Pankreatitis ist zusätzlich zur Antigiftbehandlung erforderlich.
Publication History
Received: 24 June 2023
Article published online:
20 September 2023
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References
- 1 Chippaux JP. Estimating the global burden of snakebite can help to improve management. PLoS medicine 2008; 5: e221 DOI: 10.1371/journal.pmed.0050221. (PMID: 18986211)
- 2 Gerardo CJ, Vissoci JRN, Evans CS. et al. Does This Patient Have a Severe Snake Envenomation?: The Rational Clinical Examination Systematic Review. JAMA surgery 2019; 154: 346-354 DOI: 10.1001/jamasurg.2018.5069.
- 3 Di Nicola MR, Pontara A, Kass GEN. et al. Vipers of Major clinical relevance in Europe: Taxonomy, venom composition, toxicology and clinical management of human bites. Toxicology 2021; 453: 152724 DOI: 10.1016/j.tox.2021.152724. (PMID: 33610611)
- 4 Sagheb MM, Sharifian M, Moini M. et al. Acute renal failure and acute necrotizing pancreatitis after Echis carinatus sochureki bite, report of a rare complication from southern Iran. Prague medical report 2011; 112: 67-71
- 5 Mederos MA, Reber HA, Girgis MD. Acute Pancreatitis: A Review. Jama 2021; 325: 382-390 DOI: 10.1001/jama.2020.20317. (PMID: 33496779)
- 6 Paniagua D, Vergara I, Román R. et al. Antivenom effect on lymphatic absorption and pharmacokinetics of coral snake venom using a large animal model. Clinical toxicology (Philadelphia, Pa) 2019; 57: 727-734 DOI: 10.1080/15563650.2018.1550199.
- 7 Abdullahi ZU, Musa SS, He D. et al. Antiprotozoal Effect of Snake Venoms and Their Fractions: A Systematic Review. Pathogens (Basel, Switzerland) 2021; 10 DOI: 10.3390/pathogens10121632.
- 8 Valenta J, Stach Z, Svítek M. Acute pancreatitis after viperid snake cerastes cerastes envenoming: a case report. Prague medical report 2010; 111: 69-75 (PMID: 20359440)
- 9 Rouault M, Rash LD, Escoubas P. et al. Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity. Biochemistry 2006; 45: 5800-5816 DOI: 10.1021/bi060217r.
- 10 Takeda S, Takeya H, Iwanaga S. Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM/ADAMTS family proteins. Biochimica et biophysica acta 2012; 1824: 164-176 DOI: 10.1016/j.bbapap.2011.04.009. (PMID: 21530690)
- 11 Choi JH, Kim MH, Cho DH. et al. Revised Atlanta classification and determinant-based classification: Which one better at stratifying outcomes of patients with acute pancreatitis?. Pancreatology 2017; 17: 194-200 DOI: 10.1016/j.pan.2017.01.004.
- 12 Pande R, Khan HN. Acute pancreatitis following adder bite in the UK: a case report. Annals of the Royal College of Surgeons of England 2010; 92: W25-26 DOI: 10.1308/147870810X12699662981276. (PMID: 20594405)