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DOI: 10.1055/a-2157-5925
Improved Synthesis of Unsymmetrical Ureas via Carbamates
This study was supported by the National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab (India). R.P. thanks NIPER for the award of a scholarship for doctoral studies. D.K.T. thanks the University Grants Commission (UGC), New Delhi (India) for the award of a scholarship for doctoral studies.
Abstract
An efficient, cost-effective, easy and green method is reported for the preparation of N,N′-alkyl aryl ureas and N,N′-dialkylureas via carbamates. This improved procedure is devoid of any hazardous reagents such as phosgene and isocyanates, and shows broad substrate scope with good to excellent yields. As compared to previous reports, this procedure offers an operationally simple, potentially scalable, and, significantly, benign way to synthesize these important urea motifs.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2157-5925.
- Supporting Information
Publication History
Received: 18 July 2023
Accepted after revision: 18 August 2023
Accepted Manuscript online:
21 August 2023
Article published online:
26 October 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)
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