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Exp Clin Endocrinol Diabetes 2023; 131(11): 615-623
DOI: 10.1055/a-2159-6468
Article

Maternal Hyperglycemia Induces Autonomic Dysfunction and Heart Failure in Older Adult Offspring

Odair Alves da Silva
1   Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil
,
Glória Pinto Duarte
1   Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, Brazil
,
Saad Lahlou
2   Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, Brazil
› Author Affiliations Fundings This study was supported by the “Coordenação de Aperfeiçoamento de Pessoal de Nível Superior,” Brazil [CAPES, 001], the “Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco” [FACEPE, 16/2012 APQ-1133–2.0720/12], and the “Conselho Nacional de Desenvolvimento Científico e Tecnológico” Pronex/FACEPE/ CNPq [APQ 0780–4.03/09].
Funding Information Conselho Nacional de Desenvolvimento Científico e Tecnológico — http://dx.doi.org/10.13039/501100003593; APQ 0780–4.03/09 Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco — http://dx.doi.org/10.13039/501100006162; FACEPE, 16/2012 APQ-1133–2.0720/12 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior — http://dx.doi.org/10.13039/501100002322; 001
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Abstract

Aims Offspring exposed to an adverse fetal environment, such as gestational diabetes, may manifest increased susceptibility to several chronic diseases later in life. In the present study, the cardiovascular function of three different ages of offspring from diabetic rats was evaluated.

Methods and results Diabetes mellitus was induced in pregnant rats by a single dose of streptozotocin (50 mg/kg). The offspring from diabetic (OD) and control rats (OC) were evaluated at three different ages: 6, 12 or 18 months. In the corresponding OC groups, fasting glycemia, baseline mean arterial pressure, and sympathetic tonus increased in the OD rats at 12 (OD12) and 18 (OD18) months of age, while cardiac hypertrophy was observed in all OD groups. Cardiac function evaluation in vivo showed low left ventricular systolic pressure and+dP/dt in the OD18 rats, suggesting a systolic dysfunction. OD12 and OD18 groups showed high left ventricle end-diastolic pressure, suggesting a diastolic dysfunction. OD groups showed an age-related impairment of both baroreflex-mediated tachycardia and baroreflex-mediated bradycardia in OD12 and OD18 rats. In isolated hearts from OD18 rats, both inotropic and tachycardiac responses to increasing isoproterenol were significantly reduced compared to the corresponding OC group.

Conclusion These results suggest that gestational diabetes triggers the onset of hyperglycemia hypertension with impaired baroreflex sensitivity and heart failure in older age of offspring, representing important risk factors for death. Therefore, ensuring optimal glycemic control in diabetic pregnancy is important and serves as a key to preventing cardiovascular disease in the offspring in their older age.

Key words

autonomic function - baroreflex sensitivity - heart failure - hyperglycemia - maternal diabetes


Publication History

Received: 29 December 2022
Received: 07 August 2023

Accepted: 16 August 2023

Article published online:
27 September 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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