Systematisches Review: Risikofaktoren Ängstlichkeit, Depressivität und (mangelnde) soziale Unterstützung bei Frauen und Männern vor assistierter Reproduktion

Zusammenfassung

Dieses Review gibt einen systematischen Überblick des bisherigen Kenntnisstandes der psychosozialen Risikofaktoren mit Schwerpunkt auf Ängstlichkeit, Depressivität und (mangelnder) sozialer Unterstützung von ungewollt kinderlosen Frauen und Männern vor assistierter Reproduktion. Die Datenbanken PubMed, PubPsych, PsycINFO-Ebsco und Web of Science wurden nach relevanten Publikationen auf Englisch oder Deutsch durchsucht, und schlussendlich wurden insgesamt 20 Publikationen in das systematische Review einbezogen. Dabei fokussierten 18 Studien auf Depressivität, 15 Studien auf Ängstlichkeit und 9 Studien auf soziale Unterstützung. Die Hälfte der Studien beinhaltete sowohl Männer als auch Frauen, während in der anderen Hälfte nur Frauen berücksichtigt wurden. Aufgrund der großen Heterogenität der Studienergebnisse sowie der Limitationen können keine eindeutigen Schlussfolgerungen hinsichtlich eines Unterschiedes zwischen den Risikoprofilen von Männern und Frauen mit unerfülltem Kinderwunsch gezogen werden. Es konnte jedoch gezeigt werden, dass infertile Paare bzw. Frauen im Vergleich zu fertilen Teilnehmerinnen und Teilnehmern eine höhere Belastung in Form von Depressivität und Ängstlichkeit erfahren. Des Weiteren wurde festgestellt, dass soziale Unterstützung, unabhängig vom Geschlechterunterschied, innerhalb des Paares sowie durch die Familie und Freunde mit geringerem Risiko für Depressivität und Ängstlichkeit verbunden sein kann.

Schlüsselwörter

unerfüllter Kinderwunsch - Ängstlichkeit - Depressivität - soziale Unterstützung - assistierte Reproduktion (ART)

Publication History

Received: 31 May 2023

Accepted after revision: 19 August 2023

Article published online:
03 November 2023

• References/Literatur

• 1 Mascarenhas MN, Flaxman SR, Boerma T. et al. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med 2012; 9: e1001356 DOI: 10.1371/journal.pmed.1001356.
• 2 Boivin J, Bunting L, Collins JA. et al. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum Reprod 2007; 22: 1506-1512 DOI: 10.1093/humrep/dem046. (PMID: 17376819)
• 3 Xie Y, Ren Y, Niu C. et al. The impact of stigma on mental health and quality of life of infertile women: A systematic review. Front Psychol 2023; 13: 1093459 DOI: 10.3389/fpsyg.2022.1093459. (PMID: 36698573)
• 4 Luk BH, Loke AY. The Impact of Infertility on the Psychological Well-Being, Marital Relationships, Sexual Relationships, and Quality of Life of Couples: A Systematic Review. J Sex Marital Ther 2015; 41: 610-625 DOI: 10.1080/0092623X.2014.958789. (PMID: 25211377)
• 5 Chachamovich JR, Chachamovich E, Ezer H. et al. Investigating quality of life and health-related quality of life in infertility: a systematic review. J Psychosom Obstet Gynaecol 2010; 31: 101-110 DOI: 10.3109/0167482x.2010.481337. (PMID: 20443659)
• 6 Greil AL. Infertility and psychological distress: a critical review of the literature. Soc Sci Med 1997; 45: 1679-1704 DOI: 10.1016/s0277-9536(97)00102-0. (PMID: 9428088)
• 7 Greil AL, Slauson-Blevins K, McQuillan J. The experience of infertility: a review of recent literature. Sociol Health Illn 2010; 32: 140-162 DOI: 10.1111/j.1467-9566.2009.01213.x. (PMID: 20003036)
• 8 Wischmann T, Borkenhagen A, David M. et al. Psychosomatically Oriented Diagnostics and Therapy for Fertility Disorders. Guideline of the DGPFG (S2k-Level, AWMF Registry Number 016/003, December 2019). Geburtshilfe Frauenheilkd 2021; 81: 749-768 DOI: 10.1055/a-1341-9664. (PMID: 34276062)
• 9 Peterson BD, Sejbaek CS, Pirritano M. et al. Are severe depressive symptoms associated with infertility-related distress in individuals and their partners?. Hum Reprod 2014; 29: 76-82 DOI: 10.1093/humrep/det412. (PMID: 24256990)
• 10 Donarelli Z, Lo Coco G, Gullo S. et al. Are attachment dimensions associated with infertility-related stress in couples undergoing their first IVF treatment? A study on the individual and cross-partner effect. Hum Reprod 2012; 27: 3215-3225 DOI: 10.1093/humrep/des307. (PMID: 22926837)
• 11 Edelmann RJ, Connolly KJ. Gender differences in response to infertility and infertility investigations: Real or illusory. Br J Health Psychol 2000; 5: 365-375
• 12 Quinlivan J, Rowe H, Wischmann T. et al. Setting the global research agenda in psychosocial aspects of women’s health – outcomes from ISPOG world conference at The Hague. J Psychosom Obstet Gynaecol 2020; 41: 1-4 DOI: 10.1080/0167482X.2020.1695872. (PMID: 31805800)
• 13 Gameiro S, Boivin J, Dancet E. et al. ESHRE guideline: routine psychosocial care in infertility and medically assisted reproduction-a guide for fertility staff. Hum Reprod 2015; 30: 2476-2485 DOI: 10.1093/humrep/dev177. (PMID: 26345684)
• 14 Eskew AM, Jungheim ES. A History of Developments to Improve in vitro Fertilization. Mo Med 2017; 114: 156-159 (PMID: 30228571)
• 15 Quant HS, Zapantis A, Nihsen M. et al. Reproductive implications of psychological distress for couples undergoing IVF. J Assist Reprod Genet 2013; 30: 1451-1458 DOI: 10.1007/s10815-013-0098-7. (PMID: 24043383)
• 16 Agostini F, Monti F, Paterlini M. et al. Effect of the previous reproductive outcomes in subfertile women after in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) treatments on perinatal anxious and depressive symptomatology. J Psychosom Obstet Gynaecol 2018; 39: 29-37 DOI: 10.1080/0167482x.2017.1286474. (PMID: 28635535)
• 17 Moura-Ramos M, Gameiro S, Canavarro MC. et al. Does infertility history affect the emotional adjustment of couples undergoing assisted reproduction? The mediating role of the importance of parenthood. Br J Health Psychol 2016; 21: 302-317 DOI: 10.1111/bjhp.12169.
• 18 von Elm E, Altman DG, Egger M. et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies. Ann Intern Med 2007; 147: 573-577 DOI: 10.7326/0003-4819-147-8-200710160-00010. (PMID: 25046131)
• 19 Aldemir S, Eser A, Ozturk Turhan N. et al. Relation of anxiety and depressive symptoms with perceived social support according to gender within infertile couples. Dusunen Adam 2015; 28: 328-336 DOI: 10.5350/DAJPN2015280404.
• 20 Al-Homaidan HT. Depression among Women with Primary Infertility attending an Infertility Clinic in Riyadh, Kingdom of Saudi Arabia: Rate, Severity, and Contributing Factors. Int J Health Sci (Qassim) 2011; 5: 108-115 (PMID: 23267288)
• 21 Alhassan A, Ziblim AR, Muntaka S. A survey on depression among infertile women in Ghana. BMC Womens Health 2014; 14: 42 DOI: 10.1186/1472-6874-14-42. (PMID: 24612693)
• 22 Baghiani Moghadam MH, Aminian AH, Abdoli AM. et al. Evaluation of the general health of the infertile couples. Iran J Reprod Med 2011; 9: 309-314 (PMID: 26396581)
• 23 Batool SS, de Visser RO. Psychosocial and contextual determinants of health among infertile women: a cross-cultural study. Psychol Health Med 2014; 19: 673-679 DOI: 10.1080/13548506.2014.880492. (PMID: 24479424)
• 24 Berg BJ, Wilson JF. Psychiatric morbidity in the infertile population: a reconceptualization. Fertil Steril 1990; 53: 654-661 (PMID: 2318324)
• 25 Connolly KJ, Edelmann RJ, Cooke ID. et al. The impact of infertility on psychological functioning. J Psychosom Res 1992; 36: 459-468 DOI: 10.1016/0022-3999(92)90006-n. (PMID: 1619585)
• 26 Dadhwal V, Choudhary V, Perumal V. et al. Depression, anxiety, quality of life and coping in women with infertility: A cross-sectional study from India. Int J Gynaecol Obstet 2022; 158: 671-678 DOI: 10.1002/ijgo.14084. (PMID: 34957556)
• 27 Giannouli V, Stoyanova S. Exploring emotional aspects of infertility in women from two countries. Psychiatriki 2018; 29: 34-41 DOI: 10.22365/jpsych.2018.291.34. (PMID: 29754118)
• 28 Karlidere T, Bozkurt A, Yetkin S. et al. [Is there gender difference in infertile couples with no axis one psychiatric disorder in context of emotional symptoms, social support and sexual function?]. Turk Psikiyatri Derg 2007; 18: 311-322 (PMID: 18066722)
• 29 Kiesswetter M, Marsoner H, Luehwink A. et al. Impairments in life satisfaction in infertility: Associations with perceived stress, affectivity, partnership quality, social support and the desire to have a child. Behav Med 2020; 46: 130-141 DOI: 10.1080/08964289.2018.1564897. (PMID: 30726170)
• 30 Mao J, Guo HP, Wang J. et al. Analysis of Related Factors of Coping Styles in Infertile Patients in Central China. Patient Prefer Adherence 2022; 16: 1605-1612 DOI: 10.2147/ppa.S364345. (PMID: 35812764)
• 31 Matsubayashi H, Hosaka T, Izumi S. et al. Emotional distress of infertile women in Japan. Hum Reprod 2001; 16: 966-969 DOI: 10.1093/humrep/16.5.966. (PMID: 11331646)
• 32 Matsubayashi H, Hosaka T, Izumi S. et al. Increased depression and anxiety in infertile Japanese women resulting from lack of husband’s support and feelings of stress. Gen Hosp Psychiatry 2004; 26: 398-404 DOI: 10.1016/j.genhosppsych.2004.05.002. (PMID: 15474640)
• 33 Noorbala AA, Ramezanzadeh F, Abedinia N. et al. Psychiatric disorders among infertile and fertile women. Soc Psychiatry Psychiatr Epidemiol 2009; 44: 587-591 DOI: 10.1007/s00127-008-0467-1. (PMID: 19023508)
• 34 Pinar G, Zeyneloglu HB. Quality of life, anxiety and depression in Turkish women prior to receiving assisted reproductive techniques. Int J Fertil Steril 2012; 6: 1-12 (PMID: 25505505)
• 35 Sadiq U, Rana F, Munir M. Marital Quality, Self-compassion and Psychological Distress in Women with Primary Infertility. Sex Disabil 2022; 40: 167-177 DOI: 10.1007/s11195-021-09708-w.
• 36 Shafierizi S, Faramarzi M, Esmaelzadeh S. et al. Does infertility develop posttraumatic growth or anxiety/depressive symptoms? Roles of personality traits, resilience, and social support. Perspect Psychiatr Care 2022; 58: 2017-2028 DOI: 10.1111/ppc.13023. (PMID: 34997934)
• 37 Vo TM, Tran QTT, Le CV. et al. Depression and associated factors among infertile women at Tu Du hospital, Vietnam: a cross-sectional study. Int J Womens Health 2019; 11: 343-351 DOI: 10.2147/ijwh.S205231. (PMID: 31239787)
• 38 Wischmann T, Stammer H, Scherg H. et al. Psychosocial characteristics of infertile couples: a study by the ‘Heidelberg Fertility Consultation Service’. Hum Reprod 2001; 16: 1753-1761 DOI: 10.1093/humrep/16.8.1753. (PMID: 11473978)
• 39 Karlidere T, Bozkurt A, Ozmenler KN. et al. The influence of emotional distress on the outcome of in-vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) treatment among infertile Turkish women. Isr J Psychiatry Relat Sci 2008; 45: 55-64 (PMID: 18587170)
• 40 Kiani Z, Simbar M, Hajian S. et al. The prevalence of depression symptoms among infertile women: a systematic review and meta-analysis. Fertil Res Pract 2021; 7: 6 DOI: 10.1186/s40738-021-00098-3. (PMID: 33663615)
• 41 UNDP. Human Development Report 2021/2022. New York: UNDP (United Nations Development Programme); 2022
• 42 Fisher JR, Hammarberg K. Psychological and social aspects of infertility in men: an overview of the evidence and implications for psychologically informed clinical care and future research. Asian J Androl 2012; 14: 121-129 DOI: 10.1038/aja.2011.72. (PMID: 22179515)
• 43 Cousineau TM, Domar AD. Psychological impact of infertility. Best Pract Res Clin Obstet Gynaecol 2007; 21: 293-308 DOI: 10.1016/j.bpobgyn.2006.12.003. (PMID: 17241818)
• 44 Thanscheidt CL, Pätsch P, Rösner S. et al. Psychological Aspects of Infertility – Results from an Actor–Partner Interdependence Analysis. Geburtshilfe Frauenheilkd 2023; 83: 843-849 DOI: 10.1055/a-2041-2831.