Der Große Wiesenknopf Sanguisorba officinalis L.

Sanguisorba officinalis L. ist eine traditionell genutzte Arzneipflanze aus der Familie der Rosaceae. Das Kraut und die Wurzeln enthalten ein breites Spektrum phenolischer und terpenoider Inhaltsstoffe mit vor allem entzündungshemmenden und antiinfektiven Wirkungen. Die Wurzeldroge spielt in der Traditionellen Chinesischen Medizin zur Immunmodulation, Wundbehandlung und Therapie von Infektionen eine wichtige Rolle, wobei sich diese Indikationen mit denen der Traditionellen Europäischen Medizin teilweise überschneiden. Trotz der langen therapeutischen Verwendung ist die klinische Studienlage gegenwärtig unbefriedigend.

Sanguisorba officinalis L. (great burnet) from the Rosaceae family is a plant that has long been used in traditional medicine. The herb and roots contain a wide range of phenolic and terpenoid constituents, which primarily have anti-inflammatory and anti-infective effects. The root drug plays an important role in Traditional Chinese Medicine for immune modulation, wound treatment and therapy of infections. However, these indications partially overlap with those of Traditional European Medicine. Despite its long-term therapeutic use, there are still a lot of gaps to be filled with regard to great burnet's current clinical studies.

Schlüsselwörter

Sanguisorba officinalis L. - Großer Wiesenknopf - traditionelle Verwendung - Pharmakologie

Key words

Sanguisorba officinalis L. - Great burnet - traditional use - pharmacology

Publikationsverlauf

Artikel online veröffentlicht:
26. Februar 2024

• Literatur

• 1 Melzig MF, Hiller K. Lexikon der Arzneipflanzen und Drogen. 3. Aufl. Berlin: Springer Spektrum; 2023: 871-872
• 2 Madaus G. Lehrbuch der biologischen Heilmittel. Bd. III [Nachdruck der Ausgabe Leipzig 1938]. Hildesheim, New York: Georg Olms Verlag; 1979: 2428-2432
• 3 Ping Z, Jingyan L, Qi C. et al. A comprehensive review of genus Sanguisorba: traditional uses, chemical constituents and medical applications. Front Pharmacol 2021; 12: 750165
• 4 Aichele D, Schwegler HW. Die Blütenpflanzen Mitteleuropas. Bd. 2. Stuttgart: Franckh-Kosmos; 1994: 411-412
• 5 Fuchs L. Von Kölbleskraut. In: Fuchs L. New Kreüterbuch. Basel 1543. Reprint Köln: Taschen-Verlag; 2001: Cap. CCCVII
• 6 Hegi G. Illustrierte Flora von Mitteleuropa. Scholz H, Hrsg. 2. Aufl. Bd. IV. Teil 2B. Berlin, Wien: Blackwell Wissenschaftsverlag; 1995: 46
• 7 European Pharmacopoeia 11.1. Sanguisorba root. 04/2021: 2385
• 8 Homöopathisches Arzneibuch 2022. Sanguisorba officinalis. Stuttgart: Deutscher Apotheker Verlag; 2022
• 9 Bunse M, Lorenz P, Stintzing FC. et al. Characterization of secondary metabolites in flowers of Sanguisorba officinalis L. by HPLC-DAD-MS and GC/MS. Chem Biodivers 2020; 17: e1900724
• 10 Zhao Z, He X, Zhang Q. et al. Traditional uses, chemical constituents and biological activities of plants from the genus Sanguisorba L. Am J Chin Med 2017; 45: 199-224
• 11 Chen JF, Tan L, Ju F. et al. Phenolic glycosides from Sanguisorba officinalis and their anti-inflammatory effects. Nat Prod Res 2022; 36: 2097-2104
• 12 Li C, Gong L, Jiang Y. et al. Sanguisorba officinalis ethyl acetate extract attenuates ulcerative colitis through inhibiting PI3K-AKT/NF-κB/ STAT3 pathway uncovered by single-cell RNA sequencing. Phytomedicine 2023; 120: 155052
• 13 Zhou P, Lai J, Li Y. et al. Methyl gallate alleviates acute ulcerative colitis by modulating gut microbiota and inhibiting TLR4/NF-κB pathway. Int J Mol Sci 2022; 23: 14024
• 14 Lee YE, Kim S, Jung WJ. et al. Immunomodulatory effects of ZYM-201 on LPS-stimulated B cells. Immune Netw 2014; 14: 260-264
• 15 Song J, Zeng J, Zheng S. et al. Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage. Phytother Res 2023; 37: 4265-4281
• 16 Gao X, Wu J, Zou W. et al. Two ellagig acids isolated from roots of Sanguisorba officinalis L. promote hematopoietic progenitor cell proliferation and megakaryocyte differentiation. Molecules 2014; 19: 5448-5458
• 17 Chen X, Li B, Gao Y. et al. Saponins from Sanguisorba officinalis improve hematopoiesis by promoting survival through FAK and Erk1/2 activation and modulating cytokine production in bone marrow. Front Pharmacol 2017; 8: 130
• 18 Montenegro-Landívar MF, Tapia-Quirós P, Vecino X. et al. Polyphenols and their potential role to fight viral diseases: An overview. Sci Total Environ 2021; 801: 149719
• 19 Liang J, Chen J, Tan Z. et al. Extracts of the medicinal herb Sanguisorba officinalis inhibit the entry of human immunodeficiency virus-1. J Food Drug Anal 2013; 21: S52-S58
• 20 Liu J, Zu M, Chen K. et al. Screening of neuraminidase inhibitory activities of some medicinal plants traditionally used in Lingnan Chinese medicines. BMC Complement Altern Med 2018; 18: 102
• 21 Jung IG, Jeong JY, Yum SH. et al. Inhibitory effects of selected medicinal plants on bacterial growth of methicillin-resistant Staphylococcus aureus . Molecules 2022; 27: 7780
• 22 Wang S, Luo J, Liu XQ. et al. Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus . Lett Appl Microbiol 2021; 72: 238-244
• 23 Pu Z, Tang H, Long N. et al. Assessment of the anti-virulence potential of extracts from four plants used in traditional Chinese medicine against multidrug-resistant pathogens. BMC Complement Med Ther 2020; 20: 318
• 24 Chen P, Chen M, Peng C. et al. In vitro anti-bactrical activity and its preliminary mechanism of action of the non-medicinal parts of Sanguisorba officinalis L. against Helicobacter pylori infection. J Ethnopharmacol 2024; 318: 116981
• 25 Gan T, Liu YD, Wang Y. et al. Traditional Chinese medicine herbs for stopping bleeding from haemorrhoids. Cochrane Database Syst Rev 2010; 10: CD006791
• 26 Zheng K, Shen H, Jia J. et al. Traditional Chinese medicine combination therapy for patients with steroid-dependent ulcerative colitis: study protocol for a randomized controlled trial. Trials 2017; 18: 8
• 27 He HH, Shen H, Zheng K. Observation of the curative effect of qingchang huashi recipe for treating active ulcerative colitis of inner-accumulation of damp-heat syndrome. Zhongguo Zhong Xi Yi Jie He Za Zhi 2012; 32: 1598-1601
• 28 Bracher F. et al. Hrsg. Arzneibuch-Kommentar. Wissenschaftliche Erläuterungen zum Arzneibuch. Großer-Wiesenknopf-Wurzel. Stuttgart: Wiss. Verlagsges. 57. Lfg. 2017. Stand: 73. Lfg; 2023