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Rofo 2024; 196(02): 134-153
DOI: 10.1055/a-2178-2846
Positionspapier

Positionspapier zur Implementierung eines nationalen organisierten Programms in Deutschland zur Früherkennung von Lungenkrebs in Risikopopulationen mittels Low-dose-CT-Screening inklusive Management von abklärungsbedürftigen Screeningbefunden

Statement paper on the implementation of a national organized program in Germany for the early detection of lung cancer in risk populations using low-dose CT screening including management of screening findings
Jens Vogel-Claussen   *
1   Institut für Diagnostische und Interventionelle Radiologie, Medizinische Hochschule Hannover, Hannover, Deutschland
2   Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Deutsches Zentrum für Lungenforschung, Hannover, Deutschland
,
Torsten Gerriet Blum   *
3   Klinik für Pneumologie, Lungenklinik Heckeshorn, Helios Klinikum Emil von Behring, Berlin, Deutschland
4   Medical School Berlin, Berlin, Deutschland
,
Stefan Andreas
5   Lungenfachklinik Immenhausen, Immenhausen
6   Klinik für Kardiologie und Pneumologie, Universitätsmedizin Göttingen, Deutschland
7   Deutsches Zentrum für Lungenforschung, Gießen, Deutschland
,
Torsten T. Bauer
3   Klinik für Pneumologie, Lungenklinik Heckeshorn, Helios Klinikum Emil von Behring, Berlin, Deutschland
,
Jörg Barkhausen
8   Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Deutschland
,
Volker Harth
9   Zentralinstitut für Arbeitsmedizin und Maritime Medizin, Universitätsklinikum Hamburg-Eppendorf, Deutschland
,
Hans-Ulrich Kauczor
10   Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Deutschland
11   Translational Lung Research Center Heidelberg, Deutsches Zentrum für Lungenforschung, Deutschland
,
Wulf Pankow
12   Taskforce Tabakentwöhnung, Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin, Berlin, Deutschland
,
Katrin Welcker
13   Klinik für Thoraxchirurgie, Kliniken Maria Hilf GmbH, Akademisches Lehrkrankenhaus der RWTH Aachen, Mönchengladbach, Deutschland
,
Rudolf Kaaks   **
11   Translational Lung Research Center Heidelberg, Deutsches Zentrum für Lungenforschung, Deutschland
14   Deutsches Krebsforschungszentrum, Heidelberg, Deutschland
,
Hans Hoffmann   **
15   Sektion Thoraxchirurgie, Klinikum rechts der Isar, Technische Universität München, Deutschland
,
Deutsche Röntgengesellschaft, Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin, Deutsche Gesellschaft für Thoraxchirurgie, Vorstand der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin: Prof. Dr. med. Wolfram Windisch, Prof. Dr. med. Christian Taube, Prof. Dr. med. Torsten T. Bauer, Prof. Dr. med. Antje Prasse, Vorstand der Deutschen Gesellschaft für Thoraxchirurgie: Dr. med. Katrin Welcker, Dr. med. Ludger Hillejan, Prof. Dr. med. Hans-Stefan Hofmann, PD Dr. med. habil. Robert Scheubel, Dr. med. Erich Hecker, Prof. Dr. med. Corinna Ludwig, Prof. Dr. med. Thorsten Walles, Prof. Dr. med. Hauke Winter, Vorstand der Deutschen Röntgengesellschaft: Prof. Dr. med. Konstantin Nikolaou, Prof. Dr. med. Jörg Barkhausen, Prof. Dr. med. Christiane Kuhl, Dr. rer. nat. Frank Anton, Dr. med. Stefan Neuman, Prof. Dr. med. Arnd Dörfler, PD Dr. med. Friederike Körber, Prof. Dr. rer. medic. Martin Fiebich, Prof. Dr. med. Gerald Antoch, Dr. med. Kerstin Westphalen, Prof. Dr. Ulrike Attenberger, Prof. Dr. med. Frank Wacker, Prof. Dr. med. Johannes Weßling › Author Affiliations
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Zusammenfassung

Der Prozess zur Implementierung der Lungenkrebsfrüherkennung mit Niedrigdosis-CT (LDCT) in Deutschland hat in den letzten Jahren deutlich an Dynamik gewonnen. Es wird erwartet, dass der von den Fachgesellschaften kommentierte Referentenentwurf des Bundesministeriums für Umwelt, Naturschutz, nukleare Sicherheit und Verbraucherschutz (BMUV) zur Lungenkrebsfrüherkennung noch bis Ende 2023 in Kraft tritt. Basierend auf dieser Verordnung wird der Gemeinsame Bundesausschuss (G-BA) zeitnah ein Programm zur Lungenkrebsfrüherkennung mit LDCT aufsetzten. In diesem Positionspapier stellen die im Lungenkrebsscreening beteiligten Fachgesellschaften erstmals konkrete Eckpunkte für ein einheitliches, strukturiertes und qualitätsgesichertes Früherkennungsprogramm für Lungenkrebs in Deutschland vor, um zu diesem Prozess konstruktiv beizutragen.

Abstract

The process of implementing early detection of lung cancer with low-dose CT (LDCT) in Germany has gained significant momentum in recent years. It is expected that the ordinance of the Federal Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection (BMUV) on the early detection of lung cancer, which has been commented on by the professional societies, will come into effect by the end of 2023. Based on this regulation, the Federal Joint Committee (G-BA) will set up a program for early lung cancer detection with LDCT in the near future. In this position paper, the specialist societies involved in lung cancer screening present key points for a uniform, structured and quality-assured early detection program for lung cancer in Germany to make a constructive contribution to this process.

Citation Format

  • Vogel-Claussen J, Blum TG, Andreas S et al. Position paper on the implementation of a nationally organized program in Germany for the early detection of lung cancer in high-risk populations using low-dose CT screening including the management of screening findings requiring further workup. Fortschr Röntgenstr 2024; 196: DOI 10.1055/a-2178-2846

Schlüsselwörter

Lungenkrebs-Screening - Niedrigdosis-Computertomographie - Organisiertes Früherkennungsprogramm - Rundherd-Management

Key words

Lung Cancer Screening - Low-dose Computed Tomography - Organized Early Detection Program - Nodule Management

* geteilte Erstautorenschaft


** geteilte Letztautorenschaft


Supplement



Publication History

Article published online:
10 October 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
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  • Literatur

  • 1 International Agency for Research on Cancer, World Health Organization. Cancer fact sheets. 2022 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 2 Zentrum für Krebsregisterdaten, Robert Koch Institut. Lungenkrebs (Bronchialkarzinom). 2022 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 3 Luengo-Fernandez R, Leal J, Gray A. et al. Economic burden of cancer across the European Union: a population-based cost analysis. Lancet Oncol 2013; 14: 1165-1174 DOI: 10.1016/s1470-2045(13)70442-x.
    CrossrefPubMedGoogle Scholar
  • 4 Ellis J. The impact of lung cancer on patients and carers. Chron Respir Dis 2012; 9: 39-47 DOI: 10.1177/1479972311433577.
    CrossrefPubMedGoogle Scholar
  • 5 Bonney A, Malouf R, Marchal C. et al. Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality. Cochrane Database Syst Rev 2022; 8: Cd013829 DOI: 10.1002/14651858.CD013829.pub2.
    CrossrefPubMedGoogle Scholar
  • 6 Aberle DR, Adams AM, Berg CD. et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011; 365: 395-409 DOI: 10.1056/NEJMoa1102873.
    CrossrefPubMedGoogle Scholar
  • 7 de Koning HJ, van der Aalst CM, de Jong PA. et al. Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial. N Engl J Med 2020; 382: 503-513 DOI: 10.1056/NEJMoa1911793.
    CrossrefPubMedGoogle Scholar
  • 8 Field JK, Vulkan D, Davies MPA. et al. Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis. Lancet Reg Health Eur 2021; 10: 100179 DOI: 10.1016/j.lanepe.2021.100179.
    CrossrefPubMedGoogle Scholar
  • 9 Hunger T, Wanka-Pail E, Brix G. et al. Lung Cancer Screening with Low-Dose CT in Smokers: A Systematic Review and Meta-Analysis. Diagnostics (Basel) 2021; 11 DOI: 10.3390/diagnostics11061040.
    CrossrefPubMedGoogle Scholar
  • 10 Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft DK, AWMF). Prävention, Diagnostik, Therapie und Nachsorge des Lungenkarzinoms, Langversion 2.1, AWMF-Registernummer: 020/007OL. 2022 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 11 Herth FJF, Reinmuth N, Wormanns D. et al. [Joint Statement of the German Radiological Society and the German Respiratory Society on a Quality-Assured Early Detection Program for Lung Cancer with Low-dose CT]. Pneumologie 2019; 73: 573-577 DOI: 10.1055/a-0984-8367.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Kauczor HU, Baird AM, Blum TG. et al. ESR/ERS statement paper on lung cancer screening. Eur Radiol 2020; 30: 3277-3294 DOI: 10.1007/s00330-020-06727-7.
    CrossrefPubMedGoogle Scholar
  • 13 European Respiratory Society. Open letter – Increasing the early diagnosis of lung cancer in Europe: an essential milestone to tackle the biggest cancer killer. 2022 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 14 Institute for Quality and Efficiency in Health Care. Extracts. In: Lung cancer screening with low-dose computed tomography: IQWiG Reports – Commission No S19-02. Cologne (Germany): Institute for Quality and Efficiency in Health Care (IQWiG). © IQWiG (Institute for Quality and Efficiency in Health Care); 2020. Im Internet (Stand 22.09.2023)
    Google Scholar
  • 15 Bundesamt für Strahlenschutz. Bericht Lungenkrebsfrüherkennung mittels LDCT – Wissenschaftliche Bewertung des Bundesamtes für Strahlenschutz gemäß § 84 Absatz 3 Strahlenschutzgesetz. 2021 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 16 Bundesministerium für Umwelt, Naturschutz, nukleare Sicherheit und Verbraucherschutz. Lungenkrebs-Früherkennungs-Verordnung (LuKrFrühErkV). Referentenentwurf einer Verordnung über die Zulässigkeit der Anwendung der Niedrigdosis-Computertomographie zur Früherkennung von Lungenkrebs bei Rauchern. 2023 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 17 Treskova M, Aumann I, Golpon H. et al. Trade-off between benefits, harms and economic efficiency of low-dose CT lung cancer screening: a microsimulation analysis of nodule management strategies in a population-based setting. BMC Med 2017; 15: 162 DOI: 10.1186/s12916-017-0924-3.
    CrossrefPubMedGoogle Scholar
  • 18 Hofer F, Kauczor HU, Stargardt T. Cost-utility analysis of a potential lung cancer screening program for a high-risk population in Germany: A modelling approach. Lung Cancer 2018; 124: 189-198 DOI: 10.1016/j.lungcan.2018.07.036.
    CrossrefPubMedGoogle Scholar
  • 19 Pastorino U, Silva M, Sestini S. et al. Prolonged lung cancer screening reduced 10-year mortality in the MILD trial: new confirmation of lung cancer screening efficacy. Ann Oncol 2019; 30: 1162-1169 DOI: 10.1093/annonc/mdz117.
    CrossrefPubMedGoogle Scholar
  • 20 Doroudi M, Pinsky PF, Marcus PM. Lung Cancer Mortality in the Lung Screening Study Feasibility Trial. JNCI Cancer Spectr 2018; 2: pky042 DOI: 10.1093/jncics/pky042.
    CrossrefPubMedGoogle Scholar
  • 21 Paci E, Puliti D, Lopes Pegna A. et al. Mortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial. Thorax 2017; 72: 825-831 DOI: 10.1136/thoraxjnl-2016-209825.
    CrossrefPubMedGoogle Scholar
  • 22 Wille MM, Dirksen A, Ashraf H. et al. Results of the Randomized Danish Lung Cancer Screening Trial with Focus on High-Risk Profiling. Am J Respir Crit Care Med 2016; 193: 542-551 DOI: 10.1164/rccm.201505-1040OC.
    CrossrefPubMedGoogle Scholar
  • 23 Infante M, Cavuto S, Lutman FR. et al. Long-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography. Am J Respir Crit Care Med 2015; 191: 1166-1175 DOI: 10.1164/rccm.201408-1475OC.
    CrossrefPubMedGoogle Scholar
  • 24 Becker N, Motsch E, Trotter A. et al. Lung cancer mortality reduction by LDCT screening – Results from the randomized German LUSI trial. Int J Cancer 2020; 146: 1503-1513 DOI: 10.1002/ijc.32486.
    CrossrefPubMedGoogle Scholar
  • 25 Patz Jr EF, Pinsky P, Gatsonis C. et al. Overdiagnosis in low-dose computed tomography screening for lung cancer. JAMA Intern Med 2014; 174: 269-274 DOI: 10.1001/jamainternmed.2013.12738.
    CrossrefPubMedGoogle Scholar
  • 26 Ten Haaf K, van Rosmalen J, de Koning HJ. Lung cancer detectability by test, histology, stage, and gender: estimates from the NLST and the PLCO trials. Cancer Epidemiol Biomarkers Prev 2015; 24: 154-161 DOI: 10.1158/1055-9965.EPI-14-0745.
    CrossrefPubMedGoogle Scholar
  • 27 Gonzalez Maldonado S, Motsch E, Trotter A. et al. Overdiagnosis in lung cancer screening: Estimates from the German Lung Cancer Screening Intervention Trial. Int J Cancer 2021; 148: 1097-1105 DOI: 10.1002/ijc.33295.
    CrossrefPubMedGoogle Scholar
  • 28 Meza R, Jeon J, Toumazis I. et al. Evaluation of the Benefits and Harms of Lung Cancer Screening With Low-Dose Computed Tomography: Modeling Study for the US Preventive Services Task Force. JAMA 2021; 325: 988-997 DOI: 10.1001/jama.2021.1077.
    CrossrefPubMedGoogle Scholar
  • 29 Li M, Zhang L, Charvat H. et al. The influence of postscreening follow-up time and participant characteristics on estimates of overdiagnosis from lung cancer screening trials. Int J Cancer 2022; 151: 1491-1501 DOI: 10.1002/ijc.34167.
    CrossrefPubMedGoogle Scholar
  • 30 Rampinelli C, De Marco P, Origgi D. et al. Exposure to low dose computed tomography for lung cancer screening and risk of cancer: secondary analysis of trial data and risk-benefit analysis. BMJ 2017; 356: j347 DOI: 10.1136/bmj.j347.
    CrossrefPubMedGoogle Scholar
  • 31 Nekolla EA, Brix G, Griebel J. Lung Cancer Screening with Low-Dose CT: Radiation Risk and Benefit-Risk Assessment for Different Screening Scenarios. Diagnostics (Basel) 2022; 12 DOI: 10.3390/diagnostics12020364.
    CrossrefPubMedGoogle Scholar
  • 32 Brain K, Lifford KJ, Carter B. et al. Long-term psychosocial outcomes of low-dose CT screening: results of the UK Lung Cancer Screening randomised controlled trial. Thorax 2016; 71: 996-1005 DOI: 10.1136/thoraxjnl-2016-208283.
    CrossrefPubMedGoogle Scholar
  • 33 Rasmussen JF, Siersma V, Pedersen JH. et al. Psychosocial consequences in the Danish randomised controlled lung cancer screening trial (DLCST). Lung Cancer 2015; 87: 65-72 DOI: 10.1016/j.lungcan.2014.11.003.
    CrossrefPubMedGoogle Scholar
  • 34 van den Bergh KA, Essink-Bot ML, Borsboom GJ. et al. Long-term effects of lung cancer computed tomography screening on health-related quality of life: the NELSON trial. Eur Respir J 2011; 38: 154-161 DOI: 10.1183/09031936.00123410.
    CrossrefPubMedGoogle Scholar
  • 35 van den Bergh KA, Essink-Bot ML, Borsboom GJ. et al. Short-term health-related quality of life consequences in a lung cancer CT screening trial (NELSON). Br J Cancer 2010; 102: 27-34 DOI: 10.1038/sj.bjc.6605459.
    CrossrefPubMedGoogle Scholar
  • 36 Gareen IF, Duan F, Greco EM. et al. Impact of lung cancer screening results on participant health-related quality of life and state anxiety in the National Lung Screening Trial. Cancer 2014; 120: 3401-3409 DOI: 10.1002/cncr.28833.
    CrossrefPubMedGoogle Scholar
  • 37 Williamson S, Patterson J, Crosby R. et al. Communication of cancer screening results by letter, telephone or in person: A mixed methods systematic review of the effect on attendee anxiety, understanding and preferences. Prev Med Rep 2019; 13: 189-195 DOI: 10.1016/j.pmedr.2018.12.016.
    CrossrefPubMedGoogle Scholar
  • 38 Jonas DE, Reuland DS, Reddy SM. et al. Screening for Lung Cancer With Low-Dose Computed Tomography: An Evidence Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 198. AHRQ Publication No. 20-05266-EF-1. Rockville (MD): Agency for Healthcare Research and Quality; 2021. Im Internet (Stand 22.09.2023)
    Google Scholar
  • 39 Kaaks R, Delorme S. Lung Cancer Screening by Low-Dose Computed Tomography – Part 1: Expected Benefits, Possible Harms, and Criteria for Eligibility and Population Targeting. Rofo 2021; 193: 527-536 DOI: 10.1055/a-1290-7926.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 40 Knoke JD, Shanks TG, Vaughn JW. et al. Lung cancer mortality is related to age in addition to duration and intensity of cigarette smoking: an analysis of CPS-I data. Cancer Epidemiol Biomarkers Prev 2004; 13: 949-957
    CrossrefPubMedGoogle Scholar
  • 41 Vlaanderen J, Portengen L, Schuz J. et al. Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smoking and lung cancer in the SYNERGY Study. Am J Epidemiol 2014; 179: 290-298 DOI: 10.1093/aje/kwt273.
    CrossrefPubMedGoogle Scholar
  • 42 Moyer VA. Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2014; 160: 330-338 DOI: 10.7326/m13-2771.
    CrossrefPubMedGoogle Scholar
  • 43 Krist AH, Davidson KW, Mangione CM. et al. Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement. JAMA 2021; 325: 962-970 DOI: 10.1001/jama.2021.1117.
    CrossrefPubMedGoogle Scholar
  • 44 Hüsing A, Kaaks R. Risk prediction models versus simplified selection criteria to determine eligibility for lung cancer screening: an analysis of German federal-wide survey and incidence data. Eur J Epidemiol 2020; 35: 899-912 DOI: 10.1007/s10654-020-00657-w.
    CrossrefPubMedGoogle Scholar
  • 45 Behr CM, Oude Wolcherink MJ, MJ IJ. et al. Population-Based Screening Using Low-Dose Chest Computed Tomography: A Systematic Review of Health Economic Evaluations. Pharmacoeconomics 2023; 41: 395-411 DOI: 10.1007/s40273-022-01238-3.
    CrossrefPubMedGoogle Scholar
  • 46 Toumazis I, de Nijs K, Cao P. et al. Cost-effectiveness Evaluation of the 2021 US Preventive Services Task Force Recommendation for Lung Cancer Screening. JAMA Oncol 2021; 7: 1833-1842 DOI: 10.1001/jamaoncol.2021.4942.
    CrossrefPubMedGoogle Scholar
  • 47 Ten Haaf K, Tammemägi MC, Bondy SJ. et al. Performance and Cost-Effectiveness of Computed Tomography Lung Cancer Screening Scenarios in a Population-Based Setting: A Microsimulation Modeling Analysis in Ontario, Canada. PLoS Med 2017; 14: e1002225 DOI: 10.1371/journal.pmed.1002225.
    CrossrefPubMedGoogle Scholar
  • 48 UK National Screening Committee. UK NSC screening recommendation: Adult Lung cancer screening programme. 2022 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 49 Morgan H, Baldwin DR. Important parameters for cost-effective implementation of lung cancer screening. Br J Radiol 2023; 20220489 DOI: 10.1259/bjr.20220489.
    CrossrefPubMedGoogle Scholar
  • 50 Balata H, Ruparel M, OʼDowd E. et al. Analysis of the baseline performance of five UK lung cancer screening programmes. Lung Cancer 2021; 161: 136-140 DOI: 10.1016/j.lungcan.2021.09.012.
    CrossrefPubMedGoogle Scholar
  • 51 Vogel-Claussen J, Lasch F, Bollmann BA. et al. Design and Rationale of the HANSE Study: A Holistic German Lung Cancer Screening Trial Using Low-Dose Computed Tomography. Rofo 2022; 194: 1333-1345 DOI: 10.1055/a-1853-8291.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 52 Duell M, Wiethege T. Das erweiterte Vorsorgeangebot (EVA) zur Lungenkrebsfrüherkennung – Update 2019. DGUV Forum 2020; 15-17
    PubMedGoogle Scholar
  • 53 Blum TG, Morgan RL, Durieux V. et al. European Respiratory Society guideline on various aspects of quality in lung cancer care. Eur Respir J 2023; 61 DOI: 10.1183/13993003.03201-2021.
    CrossrefPubMedGoogle Scholar
  • 54 Deutsche Krebsgesellschaft. OncoMap. 2023 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 55 Deutsche Krebsgesellschaft. Jahresbericht der zertifizierten Lungenkrebszentren. Kennzahlenauswertung 2022. Auditjahr 2021/Kennzahlenjahr 2020. 2022 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 56 American College of Radiology Committee on Lung-RADS. Lung-RADS Assessment Categories 2022. 2022 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 57 Oudkerk M, Devaraj A, Vliegenthart R. et al. European position statement on lung cancer screening. Lancet Oncol 2017; 18: e754-e766 DOI: 10.1016/S1470-2045(17)30861-6.
    CrossrefPubMedGoogle Scholar
  • 58 Tanner NT, Kanodra NM, Gebregziabher M. et al. The Association between Smoking Abstinence and Mortality in the National Lung Screening Trial. Am J Respir Crit Care Med 2016; 193: 534-541 DOI: 10.1164/rccm.201507-1420OC.
    CrossrefPubMedGoogle Scholar
  • 59 Crosbie PA, Balata H, Evison M. et al. Implementing lung cancer screening: baseline results from a community-based 'Lung Health Check' pilot in deprived areas of Manchester. Thorax 2019; 74: 405-409 DOI: 10.1136/thoraxjnl-2017-211377.
    CrossrefPubMedGoogle Scholar
  • 60 Bach PB, Gould MK. When the average applies to no one: personalized decision making about potential benefits of lung cancer screening. Ann Intern Med 2012; 157: 571-573 DOI: 10.7326/0003-4819-157-8-201210160-00524.
    CrossrefPubMedGoogle Scholar
  • 61 International Association for the Study of Lung Cancer. United Kingdom-Based Smoking Cessation Program Reports That 30 Percent of Support in a Lung Cancer Screening Program: The Yorkshire Enhanced Stop Smoking Study (YESS). 2022 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 62 Evans WK, Gauvreau CL, Flanagan WM. et al. Clinical impact and cost-effectiveness of integrating smoking cessation into lung cancer screening: a microsimulation model. CMAJ Open 2020; 8: E585-e592 DOI: 10.9778/cmajo.20190134.
    CrossrefPubMedGoogle Scholar
  • 63 Fucito LM, Czabafy S, Hendricks PS. et al. Pairing smoking-cessation services with lung cancer screening: A clinical guideline from the Association for the Treatment of Tobacco Use and Dependence and the Society for Research on Nicotine and Tobacco. Cancer 2016; 122: 1150-1159 DOI: 10.1002/cncr.29926.
    CrossrefPubMedGoogle Scholar
  • 64 American Lung Association. Smoking Cessation Interventions and Lung Cancer Screening. 2019 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 65 Herth FJF, Reinmuth N, Wormanns D. et al. [Joint Statement of the German Radiological Society and the German Respiratory Society on a Quality-Assured Early Detection Program for Lung Cancer with Low-dose CT]. Pneumologie 2019; 73: 573-577 DOI: 10.1055/a-0984-8367.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 66 Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften. S3-Leitlinie Rauchen und Tabakabhängigkeit: Screening, Diagnostik und Behandlung. AWMF-Register Nr. 076-006. 2021 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 67 Rabenstein A, Aydin D, Lochbuhler K. [Smoking cessation interventions in clinical practice]. MMW Fortschr Med 2021; 163: 32-34 DOI: 10.1007/s15006-021-0177-0.
    CrossrefPubMedGoogle Scholar
  • 68 Ministry of Health New Zealand. The New Zealand Guidelines for Helping People to Stop Smoking. 2021 Im Internet (Stand 22.09.2023)
    PubMedGoogle Scholar
  • 69 Kastaun S, Viechtbauer W, Leve V. et al. Quit attempts and tobacco abstinence in primary care patients: follow-up of a pragmatic, two-arm cluster randomised controlled trial on brief stop-smoking advice – ABC versus 5As. ERJ Open Res 2021; 7 DOI: 10.1183/23120541.00224-2021.
    CrossrefPubMedGoogle Scholar