Total Synthesis of Marine Macrolide Natural Products by the Macrocyclization/Transannular Pyran Cyclization Strategy

Abstract

In this Account, we summarize the development of a new strategy for streamlined synthesis of tetrahydropyran-embedded macrolactones and its successful implementation to a 13-step synthesis of (–)-exiguolide and an 11-step synthesis of (+)-neopeltolide.

1 Introduction

2 Development of Macrocyclization/Transannular Pyran Cyclization Strategy

3 Total Synthesis of (–)-Exiguolide

4 Total Synthesis of (+)-Neopeltolide

5 Conclusions

Key words

synthetic methods - tandem reactions - total synthesis - macrolides - step-economy

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