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Synthesis 2024; 56(01): 187-192
DOI: 10.1055/a-2183-0324
paper

Novel Synthesis of Pyrido[2,3-b]quinoxaline-3-carboxylate Derivatives via One-Pot Buchwald Amination–Cyclization

Majdi Hajri
a   Laboratory of Physics of Lamellar Materials and Hybrids Nanomaterials, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna 7021, Bizerte, Tunisia
,
Omar Khoumeri
b   Laboratoire de Pharmaco-Chimie Radicalaire, Institut de Chimie Radicalaire ICR, Aix-Marseille Université, CNRS, UMR 7273, Marseille, France
,
Raoudha Abderrahim
a   Laboratory of Physics of Lamellar Materials and Hybrids Nanomaterials, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna 7021, Bizerte, Tunisia
,
Thierry Terme
b   Laboratoire de Pharmaco-Chimie Radicalaire, Institut de Chimie Radicalaire ICR, Aix-Marseille Université, CNRS, UMR 7273, Marseille, France
,
Patrice Vanelle∗
b   Laboratoire de Pharmaco-Chimie Radicalaire, Institut de Chimie Radicalaire ICR, Aix-Marseille Université, CNRS, UMR 7273, Marseille, France
› Author AffiliationsThis work was supported by the Centre National de la Recherche Scientifique and Aix-Marseille Université. We also thank the Ministry of Higher Education of Tunisia for financing this work.
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Abstract

A novel series of pyrido[2,3-b]quinoxaline-3-carboxylate derivatives was synthesized in short reaction times and in moderate to good yields by using a palladium catalyst in a one-pot Buchwald amination/cyclization reaction.

Key words

quinoxalines - nucleophilic substitutions - malonic esters - Buchwald amination/cyclization - palladium catalysis - pyrido[2,3-b]quinoxaline-3-carboxylates

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2183-0324.
  • Supporting Information


Publication History

Received: 26 June 2023

Accepted after revision: 27 September 2023

Accepted Manuscript online:
27 September 2023

Article published online:
31 October 2023

© 2023. Thieme. All rights reserved

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