Polyendokrine Syndrome beim Hund

Zusammenfassung

Das autoimmune polyendokrine Syndrom (APS) ist eine beim Hund selten vorkommende Kombination autoimmun bedingter endokriner Erkrankungen. Häufige Kombinationen sind Hypothyreose mit Hypoadrenokortizismus oder Diabetes mellitus. Des Weiteren können seltener Hypoparathyreoidismus und Orchitis als Teil eines APS auftreten. Die Diagnose des APS erfolgt über die Diagnose der jeweiligen Erkrankungen. Ebenso besteht die Therapie des APS in der Therapie der beteiligten Erkrankungen, d.h. in der Substitution der defizienten Hormone. Entstehen unter einer zuvor stabilen Therapie einer endokrinen Erkrankung weitere Symptome (z.B. Polyurie, Polydipsie oder Gewichtsverlust), sollte an die zusätzliche Entstehung anderer Endokrinopathien wie Hypoadrenokortizismus oder Diabetes mellitus gedacht werden. Die Diagnose der initial diagnostizierten Endokrinopathie sollte jedoch ebenfalls kritisch hinterfragt werden. Dieser Artikel fasst Fallberichte aus dem eigenen Patientengut sowie ausgewählte Fallberichte aus der Literatur mit ihren Besonderheiten zusammen.

Abstract

The autoimmune polyendocrine syndrome (APS) refers to a combination of autoimmune endocrine disorders. It is rarely described in dogs. The most common combinations are hypoadrenocorticism and hypothyroidism, followed by diabetes mellitus, and less often hypoparathyroidism and orchitis. The diagnosis of the APS is based on the diagnosis of each endocrinopathy, as is the therapy, which involves the substitution of deficient hormones. If a patient was previously stable under treatment and is showing further signs (e.g. polyuria, polydipsia, or weight loss), the development of additional endocrinopathies like hypoadrenocorticism or diabetes mellitus should be considered. The diagnosis of the initially diagnosed endocrinopathy should also be critically questioned. This article summarizes some cases of our own animal hospital and selected cases published in the available literature.

Schlüsselwörter

Endokrinologie - Autoimmunität - Schmidt-Syndrom - Hypoadrenokortizismus - Hypothyreose - Diabetes mellitus

Key words

Endocrinology - autoimmunity - Schmidt’s syndrome - hypoadrenocorticism - hypothyroidism - diabetes mellitus

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