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CC BY-NC-ND 4.0 · AJP Rep 2023; 13(04): e98-e101
DOI: 10.1055/a-2184-0756
Case Report

Pregnancy in a Patient with Spinal Muscular Atrophy and Severe Restrictive Lung Disease

Lamia A. Alamri
1   Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado
,
Alexandra M. Foxx
2   Department of Obstetrics and Gynecology, University of Michigan Health, Ann Arbor, Michigan
,
Robyn L. Dwan
3   Department of Anesthesiology, ANEX Anesthesia, Brookfield, Wisconsin
,
Laura E. Sorabella
4   Department of Anesthesia, Vanderbilt University Medical Center, Nashville, Tennessee
,
Soha S. Patel
5   Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee
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Abstract

Spinal muscular atrophy (SMA) is a rare autosomal recessive neuromuscular disease that is often associated with chronic respiratory failure. Few cases have described the antepartum and postpartum course in patients with severely compromised respiratory status.

We present a case of a 24-year-old nullipara with a history of SMA type II complicated by surgically corrected kyphoscoliosis and severe restrictive lung disease. Her pregnancy was complicated by progressively worsening dyspnea resulting in increased use of noninvasive positive pressure ventilation, ultimately leading to indicated premature delivery at 28 weeks' gestation via cesarean section under general anesthesia.

Women with SMA and severe restrictive lung disease are at high risk of premature delivery secondary to worsening respiratory status. A multidisciplinary approach is vital in treating these patients.

Keywords

spinal muscular atrophy - SMA - pregnancy - restrictive lung disease


Publication History

Received: 11 December 2022

Accepted: 10 September 2023

Accepted Manuscript online:
29 September 2023

Article published online:
15 December 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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