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Am J Perinatol 2024; 41(S 01): e3030-e3034
DOI: 10.1055/a-2185-4102
Original Article

Combination Foley Catheter–Oxytocin versus Oxytocin Alone following Preterm Premature Rupture of Membranes

Helen B. Gomez Slagle 
1   Division of Maternal Fetal Medicine, Columbia University Irving Medical Center, New York, New York
,
Matthew K. Hoffman 
2   Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware
,
Anthony C. Sciscione
2   Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware
3   Department of Maternal—Fetal Medicine, Delaware Center for Maternal Fetal Medicine, Newark, Delaware
,
Marwan Ma'ayeh
2   Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware
3   Department of Maternal—Fetal Medicine, Delaware Center for Maternal Fetal Medicine, Newark, Delaware
› Author Affiliations
Funding None.
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Abstract

Objective The benefit of mechanical ripening agents following preterm premature rupture of membranes (PPROM) has not been established. We sought to compare the time to delivery in women who received transcervical Foley catheter plus oxytocin infusion versus oxytocin infusion alone in patients with unfavorable cervices and PPROM.

Study Design This is a retrospective cohort study of patients presenting with PPROM of a live, singleton gestation between 240/7 and 366/7 weeks' gestation from January 2005 to October 2018 at a single, tertiary care institution. Patients with an unfavorable cervical examination (≤2-cm dilation), no contraindication to labor and undergoing labor induction were analyzed. Time to delivery was analyzed using multivariable linear regression adjusting for cervical dilation at induction and nulliparity. Bivariate and multivariate analyses were used where appropriate.

Results A total of 260 participants were included: 109 who received a Foley catheter and oxytocin (Foley/oxytocin) and 151 who had oxytocin alone. Demographic characteristics were similar between the two groups. Unadjusted time to delivery was significantly shorter in the oxytocin only group (Foley/oxytocin: 20.35 hours vs. oxytocin alone: 14.7 hours, p < 0.001). No differences in length of labor were detected after adjusting for cervical dilation at induction and nulliparity (p = 0.5). The unadjusted rate of cesarean delivery was higher in the combination Foley/oxytocin group (Foley/oxytocin: 16.5% vs. oxytocin alone: 7.3%, p = 0.03), but no differences were found in the adjusted analysis (p = 0.06). There were no differences in clinical chorioamnionitis rates between the two groups (Foley/oxytocin: 8.3% vs. oxytocin alone: 9.3%, p = 0.83). Furthermore, no significant differences were found in maternal and neonatal outcomes between the two groups.

Conclusion In patients with PROM, the use of a transcervical Foley catheter in addition to oxytocin is not associated with a shorter time to delivery compared with oxytocin alone.

Key Points

  • Transcervical Foley catheter did not shorten length of labor in PPROM.

  • Transcervical Foley catheter did not increase infection risk.

  • Pitocin alone can be used in PPROM population.

Keywords

labor induction - cervical Foley - cervical ripening - rupture of membranes - PPROM

Condensation

The use of a transcervical Foley catheter in addition to oxytocin is not associated with a shorter time to delivery compared with oxytocin alone in patients with preterm membrane rupture.


Note

The Poster Presentation of this study was held at the Society for Maternal-Fetal Medicine's 43rd Annual Pregnancy Meeting, February 6 to 11, 2023.




Publication History

Received: 11 August 2023

Accepted: 27 September 2023

Accepted Manuscript online:
04 October 2023

Article published online:
10 November 2023

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