Gesundheit von Säuglingen und Kindern: Auf den
                    Biofaktorenstatus achten

Daniela Birkelbach; Klaus Kisters; Hans-Georg Classen

doi:10.1055/a-2190-4012

Zeitschrift für Orthomolekulare Medizin, Table of Contents

Zeitschrift für Orthomolekulare Medizin 2023; 21(04): 25-31
DOI: 10.1055/a-2190-4012

Wissen

Gesundheit von Säuglingen und Kindern: Auf den Biofaktorenstatus achten

Daniela Birkelbach

,

Klaus Kisters

,

Hans-Georg Classen

Abstract

Zusammenfassung

Eine optimale Versorgung mit Biofaktoren wie Vitaminen, Mineralstoffen und Spurenelementen ist essenziell für die körperliche und geistige Entwicklung von Kindern und Jugendlichen und spielt eine wichtige Rolle in der Prävention von Erkrankungen. Bereits in der Schwangerschaft sollte auf eine ausreichende Versorgung der Mutter mit Vitamin B₁₂ und Vitamin D geachtet werden. Zusammenhänge zwischen Vitamin-D- oder Magnesiummangel und ADHS werden beschrieben.

Schlüsselwörter

Biofaktoren - Entwicklung - Kinder - Jugendliche - Vitamin B12 - Vitamin D3 - Magnesium - ADHS - Stress

Full Text

References

Literatur
1 Pietrzik K. et al. Handbuch der Vitamine. München/Jena: Urban & Fischer; 2008
2 Wolffenbuttel BHR. et al. The many faces of cobalamin (Vitamin B₁₂) deficiency. Mayo Clin Proc Innov 2019; 3: 200-214
3 Allen LH. Vitamin B₁₂ metabolism and status during pregnancy, lactation and infancy. In: Allen L, King J, Lönnerdal B, eds. Nutrition regulation during pregnancy, lactation and infant growth. New York: Springer; 1994: 173-186
4 Bala R. et al. Hyperhomocysteinemia and low vitamin B₁₂ are associated with the risk of early pregnancy loss: A clinical study and meta-analyses. Nutr Res 2021; 91: 57-66
5 Molloy AM. et al. Effects of folate and vitamin B₁₂ deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull 2008; 29: 101-111
6 Rogne T. et al. Associations of maternal vitamin B₁₂ concentration in pregnancy with the risks of preterm birth and low birth weight: A systematic review and meta-analysis of individual participant data. Am J Epidemiol 2017; 185: 212-223
7 Black MM. Effects of vitamin B₁₂ and folate deficiency on brain development in children. Food Nutr Bull 2008; 29: 126-131
8 O´Leary F. et al. Vitamin B₁₂ in health and disease. Nutrients 2010; 2: 299-316
9 www.dge.de/wissenschaft/referenzwerte/vitamin-b12/ (Stand für diese und alle nachfolgenden Internetquellen: 09.10.2023)
10 www.gf-biofaktoren.de/wissenswertes-ueber-biofaktoren/steckbriefe/folsaeure-biofaktor-fuer-zellteilung-blutbildung-und-herz-kreislaufsystem/
11 www.gf-biofaktoren.de/diagnose/uebersicht-zur-labordiagnostik/
12 Schlereth F. et al. Vitamin D – mehr als ein Knochenhormon. Internist 2016; 57: 646-655
13 Gellert S. et al. Breastfeeding women are at higher risk of vitamin D deficiency than non-breastfeeding women – insights from the German VitaMinFemin study. Int Breastfeeding J 2017; 12: 19
14 Oberhelmann SS. et al. Maternal vitamin D supplementation to improve the vitamin D status of breast-fed infants: a randomized controlled trial. Mayo Clinic Proceedings 2013; 88: 1378-1387
15 www.register.awmf.org/assets/guidelines/174-007l_S1_Vitamin-D-Mangel_Rachitis_2022-07.pdf
16 www.de.wikipedia.org/wiki/Vitamin_D
17 Tapia G. et al. Maternal and newborn vitamin D-binding protein, vitamin D levels, vitamin D receptor genotype, and childhood Type 1 Diabetes. Diabetes Care 2019; 42: 553-559
18 Lee S. et al. 1,25-Dihydroxyvitamin D₃ and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion. Endokrinologie 1994; 134: 1602-1610
19 Biliaieva E. et al. Diabetes Mellitus Type 1 In Adolescents: Impact Of Vitamin D Status. Wiad Lek 2022; 75: 387-392
20 Daskalopoulou M. et al. Vitamin D Deficiency as a Possible Cause of Type 1 Diabetes in Children and Adolescents up to 15 Years Old: A Systematic Review. Rev Diabet Stud 2022; 18: 58-67
21 Gregoriou E. et al. The Effects of Vitamin D Supplementation in Newly Diagnosed Type 1 Diabetes Patients: Systematic Review of Randomized Controlled Trials. Rev Diabet Stud 2017; 14: 260-268
22 Wang TT. et al. Cutting the edge: 1,25-dihydroxyvitamin D₃ is a direct inducer of antimicrobial peptide gene expression. J Immunol 2004; 173: 2909-2912
23 Erkkola M. et al. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clinical & Experimental Allergy 2009; 39: 875-882
24 Devereux G. et al. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr 2007; 85: 853-859
25 Islam T. et al. Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins. Neurology 2007; 69: 381-388
26 Classen HG. et al. Zink. Das unterschätzte Element. MMP 2020; 43: 149-157
27 Barnett JB. et al. Effect of zinc supplementation on serum zinc concentration and T-cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2016; 103: 942-951
28 Fukada T. et al. Zink homeostasis and signaling in health and diseases: Zinc signaling. J Biol Inorg Chem 2011; 16: 1123-1134
29 Science M. et al. Zink for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. Canad Med Assoc J 2012; 184: 551-561
30 Prasad A. et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr 2007; 85: 837-844
31 Singh M. Zinc for the common cold (Review). 2013 The Cochrane Collaboration. cochranelibrary.com/cdsr/
32 Ströhle A, Hahn A. Vitamin C und Immunfunktion. MMP 2009; 2: 49-54
33 Biancatelli Colunga RML. et al. The antiviral properties of vitamin C. Expert Rev Anti Infect Ther 2020; 18: 99-101
34 Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database. Syst Rev 2013; 31: CD000980
35 Johnston CS. et al. Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin c status: a randomized controlled trial. Nutrients 2014; 6: 2572-2584
36 www.adhs-deutschland.de
37 Khoshbakht Y. et al. Vitamin D Status and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Observational Studies. Adv Nutr 2018; 9: 9-20
38 Kotsi E. et al. Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis. Atten Defic Hyperact Disord 2019; 11: 221-232
39 Dehbokri N. et al. Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder. World J Pediatr 2019; 15: 78-84
40 Hemamy M. et al. The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial. BMC Pediatr 2021; 21: 178
41 Mohammadpour N. et al. Effect of vitamin D supplementation as adjunctive therapy to methylphenidate on ADHD symptoms: A randomized, double blind, placebo-controlled trial. Nutr Neurosci 2018; 21: 202-209
42 Pludowski P. et al. Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement. Nutrients 2022; 14: 1483
43 Liebscher DH. et al. Magnesiummangel und -therapie bei ADHS. Empfehlungen der Gesellschaft für Magnesium-Forschung e.V. Nieren- und Hochdruckkrankheiten 2011; 40: 123-128
44 Effatpanah M. et al. Magnesium status and attention deficit hyperactivity disorder (ADHD): A meta-analysis. Psychiatry Res 2019; 274: 228-234
45 Mousain-Bosc M. et al. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B₆. I. Attention deficit hyperactivity disorders. Magnes Res 2006; 19: 46-52
46 Hemamy M. et al. The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial. Pediatr 2021; 21: 178
47 www.gf-biofaktoren.de Ausführliche Informationen zur Labordiagnostik zum Nachweis eines Magnesiummangels
48 Blancquaert L. et al. Predicting and Testing Bioavailability of Magnesium Supplements. Nutrients 2019; 11: 1663
49 Jopp A. Risikofaktor Vitaminmangel. Heidelberg: Karl F. Haug-Verlag und Medizinverlage 2002; 42-82
50 Kennedy DOB. Vitamins and the brain: mechanisms, dose and efficacy – a review. Nutrients 2016; 8: 68
51 Classen HG. Systemic stress, magnesium status and cardiovascular damage. Magnesium 1986; 5: 105-110
52 Wienecke E. et al. Langzeit-HRV-Analyse zeigt Stressreduktion durch Magnesiumzufuhr. MMW 2016; 158: 12-16
53 Classen HG. et al. Magnesiummangel bei Normomagnesiämie. In: Biesalski HK, Classen HG, Hrsg. Elektrolyte, Vitamine, Spurenelemente – Kriterien eines erhöhten Bedarfs in Zielorganen bei normalen Plasmawerten. Stuttgart, New York: Georg Thieme; 1995: 38-43