Lewis Base/3d Transition-Metal Cooperatively Catalyzed Asymmetric Reactions

Abstract

Lewis base/transition-metal cooperatively catalyzed asymmetric transformations have attracted extensive attention as they offer complementary catalytic systems within the realm of cooperative catalysis. Recently, the synergistic use of Lewis bases in combination with earth-abundant 3d metals has emerged as a fascinating prospect, presenting an opportunity to move away from the reliance on noble metals and to explore novel catalytic processes. In this Account, we highlight our recent achievements regarding the chemistry and synthetic utility of isothiourea (ITU) activated C1-ammonium enolates and N-heterocyclic carbene (NHC)-bound homoenolate equivalents in conjunction with 3d transition-metal activated electrophiles. The remarkable success in the stereoselective construction of carbon–carbon and carbon–heteroatom bonds has led to significant contributions to stereodivergent synthesis.

1 Introduction

2 ITU/Copper Cooperative Catalysis

3 NHC/Copper Cooperative Catalysis

4 NHC/Nickel Cooperative Catalysis

5 Conclusion

Key words

Lewis bases - 3d transition metals - cooperative catalysis - asymmetric catalysis - stereodivergent synthesis

Publication History

Received: 08 September 2023

Accepted after revision: 16 October 2023

Accepted Manuscript online:
16 October 2023

Article published online:
01 December 2023

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