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DOI: 10.1055/a-2207-7715
A Predictive Model for Cancer-Associated Thrombosis in Japanese Cancer Patients: Findings from the J-Khorana Registry
Funding This study was supported in part by Grants-in-Aid for Scientific Research (#20K17087) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.![](https://www.thieme-connect.de/media/10.1055-s-00033990/202401/lookinside/thumbnails/10-1055-a-2207-7715_23100042-1.jpg)
Abstract
Background Although the close relationship between cancer and venous thromboembolism (VTE) has been identified, risk stratification for VTE in Japanese patients with cancer remains unclear.
Objectives This study aimed to validate the Khorana VTE risk assessment score (KRS) for VTE diagnosis and establish an optimal predictive model for VTE in Japanese patients with cancer.
Methods A total of 7,955 Japanese patients with cancer were subdivided into low- (0), intermediate- (1–2), and high-score (3) groups according to the KRS. Using 37 explanatory variables, a total of 2,833 patients with cancer were divided into derivation and validation cohorts (5:5). A risk model for Japanese participants was developed using the derivation cohort data.
Results The prevalence of VTE in low-, intermediate-, and high-score patients was 1.2, 2.5, and 4.3%, respectively. Logistic regression analysis demonstrated that cancer stage (III–IV) and KRS ≥ 2 were independent and significant predictors of VTE onset. The risk model for VTE assigned 1 point to body mass index ≥25 kg/m2 and 2 points each to the prevalence of osteochondral cancer and D-dimer level ≥1.47 µg/mL. The areas under the curve of the risk model were 0.763 and 0.656 in the derivation and validation cohorts, respectively.
Conclusion The KRS was useful in Japanese patients, and our new predictive model may be helpful for the diagnosis of VTE in Japanese patients with cancer.
X (formerly Twitter)
The Khorana VTE risk assessment score was useful in Japanese patients, and our new predictive model, using BMI, cancer site, and D-dimer level, may aid the diagnosis of VTE in Japanese patients with cancer. #VTE#VenousThromboembolism#Cancer-AssociatedThrombosis
X (formerly Twitter): @daisukesueta
Trial Registration Number
The University Hospital Medical Information Network Clinical Trials Registry (UMIN000050391).
Publication History
Received: 05 October 2023
Accepted: 07 November 2023
Accepted Manuscript online:
09 November 2023
Article published online:
08 January 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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