Abstract
A systematic highlight of syntheses reported since 2006 of 1,2,3-triazole-fused macrocycles possessing biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory and antilarval action, is presented in this review. The well-renowned Cu-catalyzed azide-alkyne cycloaddition reaction was noted to be highly efficient and is one the most common methods utilized by scientists for the synthesis of 1,4-disubstituted triazole-fused macrocycles, whereas Ru-catalyzed cycloaddition is common for the formation of 1,5-disubstituted bioactive triazoles. This review would thus be extremely beneficial for both synthetic organic and medicinal chemists.
1 Introduction
2 Anticancer Derivatives
3 Antibacterial Derivatives
4 Derivatives with Dual Activity
5 Antilarval Derivatives
6 Anti-inflammatory Derivatives
7 Antiviral Derivatives
8 Anti-trypanosomal Derivatives
9 Derivatives with Miscellaneous Activities
10 Conclusion
Key words
triazole - macrocycles - anticancer - antibacterial - antiviral - bioactivity
