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CC BY 4.0 · SynOpen 2024; 08(01): 1-38
DOI: 10.1055/a-2212-0996
review

Synthesis of Bioactive 1,2,3-Triazole-Fused Macrocycles via Azide-Alkyne Cycloaddition

Nasrin Jahan
,
Arkadip Pal
,
Inul Ansary  ∗
We sincerely thank the Department of Science and Technology and Biotechnology (Government of West Bengal) for providing financial assistance until the year 2022. N. Jahan is grateful to the Government of West Bengal for her research fellowship, Swami Vivekananda Merit Cum Means Fellowship.
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Abstract

A systematic highlight of syntheses reported since 2006 of 1,2,3-triazole-fused macrocycles possessing biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory and antilarval action, is presented in this review. The well-renowned Cu-catalyzed azide-alkyne cycloaddition reaction was noted to be highly efficient and is one the most common methods utilized by scientists for the synthesis of 1,4-disubstituted triazole-fused macrocycles, whereas Ru-catalyzed cycloaddition is common for the formation of 1,5-disubstituted bioactive triazoles. This review would thus be extremely beneficial for both synthetic organic and medicinal chemists.

1 Introduction

2 Anticancer Derivatives

3 Antibacterial Derivatives

4 Derivatives with Dual Activity

5 Antilarval Derivatives

6 Anti-inflammatory Derivatives

7 Antiviral Derivatives

8 Anti-trypanosomal Derivatives

9 Derivatives with Miscellaneous Activities

10 Conclusion

Key words

triazole - macrocycles - anticancer - antibacterial - antiviral - bioactivity


Publication History

Received: 17 October 2023

Accepted after revision: 15 November 2023

Accepted Manuscript online:
16 November 2023

Article published online:
04 January 2024

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by/4.0/)

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