Small-Molecule CO₂ Donors Accelerate Three-Component Peptide/Protein Bioconjugation with Alkylazides and Phosphines in Ionic Liquids

Abstract

Development of chemical modification techniques for peptides and proteins has been facilitated by a set of multicomponent reactions to date. This Letter demonstrates the use of small-molecule CO₂ donors to promote reaction efficiency of the coupling of alkylamine on peptides and proteins with azide-derived iminophosphorane and carbon dioxide.

Key words

multicomponent reaction - CO₂ donor - peptide - protein - amine - azide - phosphine

• References and Notes

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