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Z Geburtshilfe Neonatol 2024; 228(01): 74-79
DOI: 10.1055/a-2213-1665
Original Article

Post-COVID in women after SARS-CoV-2 infection during pregnancy – a pilot study with follow-up data from the COVID-19-related Obstetric and Neonatal Outcome Study (CRONOS)

Post-COVID bei Frauen nach SARS-CoV-2-Infektion in der Schwangerschaft – eine Pilotstudie mit Follow-up Daten aus dem COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS)-Register
Clara Backes
1   Frauenklinik, München Klinik Harlaching, München, Germany
,
Ulrich Pecks
2   Gynäkologie und Geburtshilfe, Universitätsklinikum Schleswig-Holstein Campus Kiel, Kiel, Germany
3   Maternale Gesundheit und Hebammenwissenschaft, Julius-Maximilians-Universität Würzburg Medizinische Fakultät, Würzburg, Germany
,
Corinna Nora Keil 
4   Geburtshilfe, Philipps-Universität Marburg, Marburg, Germany
,
Janine Zöllkau
5   Geburtshilfe, Universität Jena, Jena, Germany
,
Christoph Scholz
1   Frauenklinik, München Klinik Harlaching, München, Germany
,
Matthias Hütten
6   Department of Pediatrics, Maastricht University, Maastricht, Netherlands
,
Mario Rüdiger
7   Neonatologie, Uniklinikum Dresden, Dresden, Germany
,
Johanna Büchel
8   Gynäkologie und Geburtshilfe, Ludwig-Maximilians-Universität München, München, Germany
,
Kristin Andresen
9   Geburtshilfe, Universitätsklinikum Schleswig-Holstein Campus Kiel Klinik für Gynäkologie und Geburtshilfe, Kiel, Germany
,
Nadine Mand
10   Neonatologie und pädiatrische Intensivmedizin, Philipps-Universität Marburg, Marburg, Germany
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Abstract

Background Pregnant women are at an increased risk of severe COVID-19 and adverse pregnancy outcomes; data on maternal long-term outcome is scarce. We analyzed long-term follow-ups on women who experienced a SARS-CoV-2 infection during pregnancy to evaluate post-COVID symptoms, particularly fatigue, and their association with quality of life (QoL).

Methods 773 women who enrolled in the CRONOS registry between April 2020 and August 2021 were contacted for follow-up from December 2022 to April 2023. Data was gathered through a web-based questionnaire. Subsequently, study coordinators matched the follow-up data with the existing CRONOS data.

Results 110/773 (14%) women provided data. 20.9% experienced only acute symptoms during their SARS-CoV-2 infection in pregnancy, while 2.7% women experienced symptoms lasting longer than 4 weeks (long COVID). Symptoms lasting longer than 12 weeks (post-COVID) were reported by 63.6% women and occurred more often after severe COVID-19. Fatigue was the most frequently reported symptom (88%), with 55% of women still experiencing it more than one year after initial infection. 76% of women rated their QoL as “good” or “very good”. Women experiencing post-COVID reported a significantly lower QoL.

Conclusion This is the first German long-term data on women after SARS-CoV-2 infection during pregnancy, showing a high rate of post-COVID, a persistence of fatigue, and the impact on QoL. Continuous monitoring of pregnant women with COVID-19 is needed to develop comprehensive management strategies.

Zusammenfassung

Hintergrund Schwangere haben ein erhöhtes Risiko für komplizierte COVID-19-Verläufe. Daten zum mütterlichen Langzeitverlauf gibt es bisher kaum. Diese Studie evaluierte das Langzeit-Follow-up von Frauen nach SARS-CoV-2-Infektion in der Schwangerschaft, mit Fokus auf Post-COVID-Symptomen, insbesondere Müdigkeit, und Auswirkungen auf die Lebensqualität.

Methoden 773 Frauen, die von April 2020 bis August 2021 im CRONOS-Register registriert waren, wurden für ein Follow-up zwischen Dezember 2022 und April 2023 kontaktiert. Daten wurden in einem webbasierten Fragebogen erhoben. Die Follow-up Daten wurden mit vorhandenen CRONOS-Daten abgeglichen.

Ergebnisse 110 (14%) der 773 Frauen stellten Daten zur Verfügung; 20,9% waren während ihrer SARS-CoV-2-Infektion akut symptomatisch, 2.7% entwickelten Long-COVID. Über 12 Wochen persistierende Symptome (Post-COVID) wurden von 63.6% berichtet und traten häufiger nach initial schwerer COVID-19-Infektion auf. Müdigkeit war das häufigste Symptom während akuter Infektion (88%), 55% litten auch nach einem Jahr noch daran. 76% der Frauen bewerteten ihre Lebensqualität „gut“ oder „sehr gut“. Frauen mit Post-COVID bewerteten diese vergleichsweise schlechter.

Zusammenfassung Dies sind die ersten nationalen Langzeit-Daten von Frauen nach SARS-CoV-2-Infektion in der Schwangerschaft, die eine hohe Rate an Post-COVID-Symptomen, insbesondere Müdigkeit, und deren Auswirkungen auf die Lebensqualität zeigen. Ein kontinuierliches Monitoring von Schwangeren mit COVID-19 ist erforderlich, um eine optimale Betreuung dieser Frauen zu gewährleisten.

Key words

Post-COVID - Fatigue - Quality of life - maternal long-term outcome

Schlüsselwörter

Post-COVID - Müdigkeit - Lebensqualität - mütterliche Langzeitfolgen


Publikationsverlauf

Eingereicht: 31. Juli 2023

Angenommen nach Revision: 07. November 2023

Artikel online veröffentlicht:
08. Februar 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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