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DOI: 10.1055/a-2219-9724
Plant-Derived Peptides: (Neglected) Natural Products for Drug Discovery[ # ]
Research on nature-derived peptides in the laboratory of C. W. G. has been supported by the Austrian Science Fund (FWF) through projects P32109 and P36762.
Abstract
Peptides have emerged as key regulators in various physiological processes, including growth, development, stress, and defense responses within plants as well as ecological interactions of plants with microbes and animals. Understanding and harnessing plant peptides can lead to the development of innovative strategies for crop improvement, increasing agricultural productivity, and enhancing resilience to environmental challenges such as drought, pests, and diseases. Moreover, some plant peptides have shown promise in human health applications, with potential therapeutic benefits as ingredients in herbal medicines as well as novel drug leads. The exploration of plant peptides is essential for unraveling the mysteries of plant biology and advancing peptide drug discovery. This short personal commentary provides a very brief overview about the field of plant-derived peptides and a personal word of motivation to increase the number of scientists in pharmacognosy working with these fascinating biomolecules.
# This work is dedicated to Professors Rudolf Bauer, Chlodwig Franz, Brigitte Kopp, and Hermann Stuppner for their invaluable contributions and commitment to Austrian Pharmacognosy.
Publikationsverlauf
Eingereicht: 06. September 2023
Angenommen nach Revision: 21. November 2023
Artikel online veröffentlicht:
06. Juni 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Hellinger R, Sigurdsson A, Wu W, Romanova EV, Li L, Sweedler JV, Sussmuth RD, Gruber CW. Peptidomics. Nat Rev Methods Primers 2023; 3: 25
- 2 Muratspahic E, Freissmuth M, Gruber CW. Nature-derived peptides: A growing niche for GPCR ligand discovery. Trends Pharmacol Sci 2019; 40: 309-326
- 3 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Goransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Muller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Sussmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep 2013; 30: 108-160
- 4 Carpenter EJ, Matasci N, Ayyampalayam S, Wu S, Sun J, Yu J, Jimenez Vieira FR, Bowler C, Dorrell RG, Gitzendanner MA, Li L, Du W, Ullrich KK, Wickett NJ, Barkmann TJ, Barker MS, Leebens-Mack JH, Wong GK. Access to RNA-sequencing data from 1, 173 plant species: The 1000 Plant transcriptomes initiative (1KP). Gigascience 2019; 8: giz126
- 5 Cheng S, Melkonian M, Smith SA, Brockington S, Archibald JM, Delaux PM, Li FW, Melkonian B, Mavrodiev EV, Sun W, Fu Y, Yang H, Soltis DE, Graham SW, Soltis PS, Liu X, Xu X, Wong GK. 10KP: A phylodiverse genome sequencing plan. Gigascience 2018; 7: 1-9
- 6 Hellinger R, Koehbach J, Soltis DE, Carpenter EJ, Wong GK, Gruber CW. Peptidomics of circular cysteine-rich plant peptides: Analysis of the diversity of cyclotides from viola tricolor by transcriptome and proteome mining. J Proteome Res 2015; 14: 4851-4862
- 7 Retzl B, Hellinger R, Muratspahic E, Pinto MEF, Bolzani VS, Gruber CW. Discovery of a beetroot protease inhibitor to identify and classify plant-derived cystine knot peptides. J Nat Prod 2020; 83: 3305-3314
- 8 Retzl B, Zimmermann-Klemd AM, Winker M, Nicolay S, Grundemann C, Gruber CW. Exploring immune modulatory effects of cyclotide-enriched Viola tricolor preparations. Planta Med 2023; 89: 1493-1504
- 9 Wang CK, Kaas Q, Chiche L, Craik DJ. CyBase: A database of cyclic protein sequences and structures, with applications in protein discovery and engineering. Nucleic Acids Res 2008; 36: D206-D210
- 10 Tyagi A, Pankaj V, Singh S, Roy S, Semwal M, Shasany AK, Sharma A. PlantAFP: A curated database of plant-origin antifungal peptides. Amino Acids 2019; 51: 1561-1568
- 11 Das D, Jaiswal M, Khan FN, Ahamad S, Kumar S. PlantPepDB: A manually curated plant peptide database. Sci Rep 2020; 10: 2194
- 12 Hammami R, Ben Hamida J, Vergoten G, Fliss I. PhytAMP: A database dedicated to antimicrobial plant peptides. Nucleic Acids Res 2009; 37: D963-D968
- 13 Balls AK, Hale WS, Harris TH. A crystalline protein obtained from a lipoprotein of wheat flour. Cereal Chem 1942; 19: 279-288
- 14 Tam JP, Wang S, Wong KH, Tan WL. Antimicrobial peptides from plants. Pharmaceuticals (Basel) 2015; 8: 711-757
- 15 Pearce G, Strydom D, Johnson S, Ryan CA. A polypeptide from tomato leaves induces wound-inducible proteinase inhibitor proteins. Science 1991; 253: 895-897
- 16 Hellinger R, Gruber CW. Peptide-based protease inhibitors from plants. Drug Discov Today 2019; 24: 1877-1889
- 17 Muttenthaler M, King GF, Adams DJ, Alewood PF. Trends in peptide drug discovery. Nat Rev Drug Discov 2021; 20: 309-325
- 18 Al Musaimi O, Al Shaer D, Albericio F, de la Torre BG. 2022 FDA TIDES (peptides and oligonucleotides) harvest. Pharmaceuticals (Basel) 2023; 16: 336
- 19 Wang L, Wang N, Zhang W, Cheng X, Yan Z, Shao G, Wang X, Wang R, Fu C. Therapeutic peptides: Current applications and future directions. Signal Transduct Target Ther 2022; 7: 48
- 20 Grundemann C, Koehbach J, Huber R, Gruber CW. Do plant cyclotides have potential as immunosuppressant peptides?. J Nat Prod 2012; 75: 167-174
- 21 Koehbach J, OʼBrien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Goransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proc Natl Acad Sci U S A 2013; 110: 21183-21188
- 22 Huang J, Wong KH, Tay SV, How A, Tam JP. Cysteine-rich peptide fingerprinting as a general method for herbal analysis to differentiate radix astragali and radix hedysarum. Front Plant Sci 2019; 10: 973
- 23 Van der Weerden NL, McKenna J, Parisi K. Pezadeftide is a potent antifungal peptide with rapid fungicidial activity via a unique mechanism of action. J Am Acad Dermatol 2022; 87: Ab92
- 24 Gründemann C, Stenberg KG, Gruber CW. T20K: An immunomodulatory cyclotide on its way to the clinic. Int J Pept Res Ther 2019; 25: 9-13
- 25 Oguis GK, Gilding EK, Jackson MA, Craik DJ. Butterfly pea (Clitoria ternatea), a cyclotide-bearing plant with applications in agriculture and medicine. Front Plant Sci 2019; 10: 645
- 26 Alvarez CA, Barriga A, Albericio F, Romero MS, Guzman F. Identification of peptides in flowers of Sambucus nigra with antimicrobial activity against aquaculture pathogens. Molecules 2018; 23: 1033
- 27 Vergara-Barberan M, Lerma-Garcia MJ, Nicoletti M, Simo-Alfonso EF, Herrero-Martinez JM, Fasoli E, Righetti PG. Proteomic fingerprinting of mistletoe (Viscum album L.) via combinatorial peptide ligand libraries and mass spectrometry analysis. J Proteomics 2017; 164: 52-58