Tierarztl Prax Ausg G Grosstiere Nutztiere 2024; 52(01): 46-52
DOI: 10.1055/a-2246-2910
Kasuistik

Retropharyngeale Manifestation eines T-Zell-reichen B-Zell-Lymphoms bei einem 7-jährigen Isländerwallach

Retropharyngeal manifestation of T-cell-rich B-cell lymphoma in a 7-year-old Icelandic gelding
Samira Klinkel
1   Klinik für Pferde, Innere Medizin, Klinikum Veterinärmedizin, Justus-Liebig-Universität Gießen
,
Julia Marchewski
2   Institut für Veterinär-Pathologie, Justus-Liebig-Universität Gießen
,
Swantje Witt
3   Klinische Pathophysiologie und Klinische Laboratoriumsdiagnostik, Klinikum Veterinärmedizin, Justus-Liebig-Universität Gießen
,
Katja Roscher
1   Klinik für Pferde, Innere Medizin, Klinikum Veterinärmedizin, Justus-Liebig-Universität Gießen
› Author Affiliations

Zusammenfassung

Ein 7-jähriger Isländerwallach wurde mit akuter hochgradiger Dyspnoe sowie seit 6 Wochen bestehendem eitrigem Nasenausfluss vorgestellt. Klinisch standen bei der Erstuntersuchung eine hochgradige Schwellung der Mandibular- und Retropharyngeallymphknoten sowie eine gemischte Dyspnoe im Vordergrund.

Mittels Labordiagnostik, Endoskopie und zytologischer Untersuchung eines Feinnadelaspirates aus einem Mandibularlymphknoten konnte die Diagnose eines malignen Lymphoms gestellt werden. Der Wallach wurde auf Grund der infausten Prognose bei deutlich gestörtem Allgemeinbefinden euthanasiert. Die pathohistologische Untersuchung ergab ein multizentrisches T-Zell-reiches B-Zell-Lymphom.

Abstract

A 7-year-old Icelandic gelding was presented with acute severe dyspnea of one day duration and purulent nasal discharge that had been present for 6 weeks. Clinically, the initial examination focused on severe enlargement of the mandibular and retropharyngeal lymph nodes as well as a mixed dyspnea.

The diagnosis of a malignant lymphoma was evident following laboratory diagnostics, endoscopy, and cytological examination of a fine needle aspiration of a mandibular lymph node. The gelding was euthanized due to the poor prognosis and a significantly disturbed general condition. Pathohistological examination revealed a multicentric T-cell-rich B-cell lymphoma.



Publication History

Received: 24 July 2023

Accepted: 19 October 2023

Article published online:
27 February 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Baker JR, Ellis CE. A survey of post mortem findings in 480 horses 1958 to 1980: (1) causes of death. Equine Vet. J 1981; 13: 43-46
  • 2 National Animal Health Monitoring System. Baseline Reference of Equine Health and Management in the United States, 2015. In: United States Department of Agriculture, Hrsg. Equine. 2015
  • 3 Knowles EJ, Tremaine WH, Pearson GR. et al. A database survey of equine tumours in the United Kingdom. Equine Vet J 2015; DOI: 10.1111/evj.12421.
  • 4 Durham AC, Pillitteri CA, San Myint M. et al. Two hundred three cases of equine lymphoma classified according to the World Health Organization (WHO) classification criteria. Vet Pathol 2013; 50: 86-93 DOI: 10.1177/0300985812451603.
  • 5 Trope GD, McCowan CI, Tyrrell D. et al. Solitary (primary) uveal T-cell lymphoma in a horse. Vet Ophthalmol 2014; 17: 139-145 DOI: 10.1111/vop.12078.
  • 6 Rhind SM, Dixon PM.. T cell-rich B cell lymphosarcoma in the tongue of a horse. Vet Rec 1999; 145: 554-555
  • 7 Greet TRC, Boys Smith SJ, Foote AK. et al. Mandibular lymphoma in a three-year-old thoroughbred filly. Vet Rec 2011; 168: 80 DOI: 10.1136/vr.c6097.
  • 8 Dabareiner RM, Sullins KE, Goodrich LR.. Large colon resection for treatment of lymphosarcoma in two horses. J Am Vet Med Assoc 1996; 208: 895-897
  • 9 Herraez P, Berridge B, Marsh P. et al. Small intestine large granular lymphoma in a horse. Vet Pathol 2001; 38: 223-226
  • 10 Penrose LC, Brower A, Kirk G. et al. Primary cardiac lymphoma in a 10-year-old equine gelding. Vet Rec 2012; 171: 20 DOI: 10.1136/vr.100644.
  • 11 Tanimoto T, Yamasaki S, Ohtsuki Y.. Primary splenic lymphoma in a horse. J Vet Med Sci 1994; 56: 767-769
  • 12 Nyack B, Padmore CL, Dunn D. et al. Splenic lymphosarcoma in a horse. Mod Vet Pract 1984; 65: 269
  • 13 Browning AP.. Splenic lymphosarcoma in a stallion association with an acute abdominal crisis. Vet Rec 1986; 119: 178-179
  • 14 Roccabianca P, Paltrinieri S, Gallo E. et al. Hepatosplenic T-cell lymphoma in a mare. Vet Pathol 2002; 39: 508-511
  • 15 Sweeney RW, Hamir AN, Fisher RR.. Lymphosarcoma with urinary bladder infiltration in a horse. J Am Vet Med Assoc 1991; 199: 1177-1178
  • 16 Freeman SL, England GC, Bjornson S. et al. Uterine T cell lymphoma in a mare, with multicentric involvement. Vet Rec 1997; 141: 391-393
  • 17 Zeman DH, Snider TG, McClure JJ.. Vertebral lymphosarcoma as the cause of hind limb paresis in a horse. J Vet Diagn Invest 1989; 1: 187-188
  • 18 Kannegieter NJ, Alley MR.. Ataxia due to lymphosarcoma in a young horse. Aust Vet J 1987; 64: 377-379
  • 19 Montgomery JB, Duckett WM, Bourque AC.. Pelvic lymphoma as a cause of urethral compression in a mare. Can Vet J 2009; 50: 751-754
  • 20 Moore BR, Weisbrode SE, Biller DS. et al. Metacarpal fracture associated with lymphosarcoma-induced osteolysis in a horse. J Am Vet Med Assoc 1995; 207: 208-210
  • 21 Larsdotter S, Nostell K, Euler von H. Serum thymidine kinase activity in clinically healthy and diseased horses: A potential marker for lymphoma. Vet J 2015; 205: 313-316 DOI: 10.1016/j.tvjl.2015.01.019.
  • 22 Moore C, Stefanovski D, Luethy D.. Clinical performance of a commercially available thymidine kinase 1 assay for diagnosis of lymphoma in 42 hospitalized horses (2017-2020). J Vet Intern Med 2021; DOI: 10.1111/jvim.16239.
  • 23 Saulez MN, Schlipf JWJR, Cebra CK. et al. Use of chemotherapy for treatment of a mixed-cell thoracic lymphoma in a horse. J Am Vet Med Assoc 2004; 224: 733
  • 24 Vander Werf K, Davis E.. Disease remission in a horse with EHV-5-associated lymphoma. J Vet Intern Med 2013; 27: 387-389 DOI: 10.1111/jvim.12050.
  • 25 Luethy D, Frimberger AE, Bedenice D. et al. Retrospective evaluation of clinical outcome after chemotherapy for lymphoma in 15 equids (1991-2017). J Vet Intern Med 2019; 33: 953-960 DOI: 10.1111/jvim.15411.