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Synlett 2024; 35(16): 1877-1882
DOI: 10.1055/a-2251-1849
DOI: 10.1055/a-2251-1849
letter
An Efficient Access to Heteroaryl/Aryl-Annulated Pyridine Derivatives and a Study of Their Mosquito Larvicidal Activity Against Dengue Vector
This work is supported by UGC through a startup grant (No. F.30-567/2021-BSR). S.D. thanks DST INSPIRE for her Ph.D. fellowship (IF 190973).
Dedicated to Professor K. C. Majumdar on his 78th birthday
Abstract
We report a convergent synthesis of heteroaryl/aryl-annulated pyridine and quinoline derivatives by a metal-free Povarov reaction. para-Toluene sulfonic acid was used as the catalyst in this reaction, which produced the products in good yields from the corresponding aromatic amines and ethyl vinyl ether. A pyridocoumarin and a pyridopyrimidine product were evaluated for their mosquito larvicidal activity against the third instar larvae of the dengue vector mosquito Aedes aegypti. Examination of morphological changes in the larvae showed damage to the target body part after treatment with both the pyridocoumarin and pyridopyrimidine products at the LC50 concentrations.
Key words
pyridocoumarins - pyridopyrimidines - Povarov reaction - metal-free synthesis - insecticidesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2251-1849.
- Supporting Information
Publication History
Received: 22 January 2024
Accepted: 22 January 2024
Accepted Manuscript online:
22 January 2024
Article published online:
22 February 2024
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