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DOI: 10.1055/a-2257-0684
A Convenient Method for Synthesizing 1-Alkyl-2-acyl-sn-glycero-3-phosphoethanolamines
We gratefully acknowledge financial support for this research from the Institute of Rheological Functions of Food.
Dedicated to Professor Koichi Narasaka in celebration of his 80th birthday (Sanju)
Abstract
A convenient method for synthesizing 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamines (1-alkyl-2-acyl-GPEs) starting from an optical active alcohol is described. In this method, the phosphate group was introduced through the transesterification that we developed, and a protected 1-alkyl-2-lyso-GPE was employed as an intermediate. This compound is stable and serves as a common intermediate for the synthesis of various 1-alkyl-2-acyl-GPEs with different acyl groups.
Key words
ether phospholipids - glycerophospholipids - phosphoethanolamines - transesterification - phosphorylationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2257-0684.
- Supporting Information
Publication History
Received: 26 December 2023
Accepted after revision: 30 January 2024
Accepted Manuscript online:
30 January 2024
Article published online:
20 February 2024
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